Mechanisms and Methods to Understand Depressive Symptoms

Sheikh-Wu, Sameena F.; Gerber, Kathryn S; Pinto, Melissa D.; Downs, Charles A.

doi:10.1080/01612840.2021.1998261

Cited by 4 publications

(6 citation statements)

References 69 publications

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“… 38 Frailty increases an individual's likelihood of experiencing depressive symptoms, which has been linked to a reduction in the quantity of monoamines neurotransmitters (e.g., dopamine, noradrenaline, serotonin) in synaptic clefts and depressive pathophysiology. 39 , 40 Sustained expression of these neurochemical imbalances can enforce and prolong depressive symptoms, leading to increased frailty and poor health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Multidimensional Frailty and Traumatic Brain Injury among Older Adults: A Literature Review

Gerber¹,

Iriarte²,

Sierra³

2023

Invest. Educ. Enferm.

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Background. Numerous health conditions in the older adult population can be attributed to falls, including traumatic brain injury (TBI), which can lead to devastating short and long-term sequelae. Older adults are also more likely to experience frailty, which encompasses physical, psychological, and social deficits that may lead to adverse health outcomes. Our literature review synthesizes current evidence for understanding frailty in the context of TBI among older adults using the Integral Model of Frailty as a framework. Content synthesis. A total of 32 articles were identified, and 9 articles were included. The results of this review indicate that outcomes resulting from TBI are closely linked to the physical, psychological, and social domains of frailty. Conclusions. A small amount of literature currently examines frailty in the context of TBI among older adults. Using the Integral Model of Frailty to understand frailty in the context of TBI can help clinicians anticipate patient outcomes and improve care plans. We emphasize the need for a greater understanding of TBI concerning frailty to improve health outcomes among older adult patients.

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Section: Discussionmentioning

confidence: 99%

Multidimensional Frailty and Traumatic Brain Injury among Older Adults: A Literature Review

Gerber¹,

Iriarte²,

Sierra³

2023

Invest. Educ. Enferm.

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“…Biomarkers are also important in understanding the underlying mechanisms of symptom development. For example, TBI induces cytokine changes, and thus changes in levels of IL-6 (pro-inflammatory) and IL-10 (anti-inflammatory), among others, may be indicative of depressive symptoms and can be useful in depressive symptom research (Bodnar et al, 2018; Sheikh-Wu et al, 2022). Begum et al (2020) measured FGF21 and MCP-1 among concussed athletes and found that increased serum concentrations of FGF21 and MCP-1 correlated greater likelihood for reporting headache and fatigue.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Neuroinflammation in Traumatic Brain Injury

et al. 2022

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Traumatic brain injury (TBI) is characterized by neuroinflammation and structural damage leading to symptoms and altered brain function. Biomarkers are useful in understanding neuroinflammation and correlations with TBI sequalae. The purpose of this paper is to identify and discuss biomarkers of neuroinflammation used to study TBI and its sequalae. A systematic review was conducted using PubMed, CINAHL, Embase, and Web of Science. A total of 350 articles met criteria; 70 used biomarkers. PRISMA criteria were used for Quality Assessment. Articles included reviews ( n = 17), case-control ( n = 25), cross-sectional ( n = 25) studies, and randomized controlled trials ( n = 3). Twenty-seven biomarkers were identified, including inflammasomes, cytokines, neuropeptides, complement complexes, miRNA and exosomes, and glial cell-specific proteins. Biomarkers aid in predicting morbidity and mortality and advance our understanding of neuroinflammation in TBI. This systematic review advances our understanding of the neuroinflammatory response to better enable nurses and clinicians to provide informed care of TBI patients.

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“…Affective symptoms such as depression, anxiety, and stress are key features of mood or psychiatric disorders (bipolar and post-traumatic stress) (Alexopoulos, 2019; Lundberg et al, 2020a; Rohani et al, 2018; Sheikh-Wu et al, 2021). Affective symptoms are experienced across populations and, at times (stress and sadness), are normal and expected (Sheikh-Wu et al, 2021). However, unmanaged affective symptoms reduce persons' quality of life and health outcomes (Alexopoulos, 2019; Lundberg et al, 2020a; Ridout et al, 2018).…”

Section: Telomere Attrition and Symptomsmentioning

confidence: 99%

“…Specific affective (mood disorders), cognitive (function and impairment), and physical (function and activity) symptoms are seen across multiple chronic illnesses, and research indicates that the experience of symptoms, such as frequency and severity of occurrence, is influenced by environmental, psychological, and physiological factors (Miaskowski et al, 2017;Sheikh-Wu et al, 2021). Understanding the symptom experience includes an understanding of the contribution of biological and behavioral mechanisms is important as it has the potential to advance our understanding of symptoms across multiple illnesses (NINR, 2018(NINR, , 2020.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Telomeres, Cognition, Mood, and Physical Function: A Systematic Review

Sheikh-Wu

Liang

Downs

2022

Biological Research For Nursing

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Background and Purpose: Cognitive, affective, and physical symptoms and alterations in their function are seen across chronic illnesses. Data suggest that environmental, psychological, and physiological factors contribute to symptom experience, potentially through loss of telomeres (telomere attrition), structures at the ends of chromosomes. Telomere length is affected by many factors including environmental (e.g., exercise, diet, smoking) and physiological (e.g., response to stress), as well as from oxidative damage and inflammation that occurs in many disease processes. Moreover, telomere attrition is associated with chronic disease (cancer, cardiovascular disease, Alzheimer’s disease) and predicts higher morbidity and mortality rates. However, findings are inconsistent among telomere roles and relationships with health outcomes. This article aims to synthesize the current state-of-the-science of telomeres and their relationship with cognitive, affective, and physical function and symptoms. Method: A comprehensive literature search was performed in two databases: CINAHL and PUBMED. A total of 33 articles published between 2000 and 2022 were included in the final analysis. Results: Telomere attrition is associated with various changes in cognitive, affective, and physical function and symptoms. However, findings are inconsistent. Interventional studies (e.g., meditation and exercise) may affect telomere attrition, potentially impacting health outcomes. Conclusion: Nursing research and practice are at the forefront of furthering the understanding of telomeres and their relationships with cognitive, affective, and physical function and symptoms. Future interventions targeting modifiable risk factors may be developed to improve health outcomes across populations.

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Mechanisms and Methods to Understand Depressive Symptoms

Cited by 4 publications

References 69 publications

Multidimensional Frailty and Traumatic Brain Injury among Older Adults: A Literature Review

Multidimensional Frailty and Traumatic Brain Injury among Older Adults: A Literature Review

Biomarkers of Neuroinflammation in Traumatic Brain Injury

The Relationship Between Telomeres, Cognition, Mood, and Physical Function: A Systematic Review

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