Mechanisms and Clinical Applications of Stem Cell Therapy

Tora, Muhibullah S; Poth, Kelly M.; Hardcastle, Nathan; Sandor, Kaitlin; Anthony, Casey; Di, Long; Boulis, Nicholas M.

doi:10.1016/b978-0-12-813997-4.00008-6

Cited by 1 publication

(1 citation statement)

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“…MSCs can be easily isolated from readily available sources such as peripheral blood, adipose tissue, Wharton jelly of the umbilical cord, skeletal muscle, synovial fluid, placenta, and amniotic fluid 5,6 using the least invasive techniques (Figure 2) and can be readily scaled up for usage in clinical settings. Among these bone marrow‐derived, MSCs are presently most often employed in treatment and research 7 .…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cells‐ an excellent therapeutic agent for cancer

TomyTomcy,

Sindhu

2023

Asia-Pac J Clncl Oncology

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Despite rapid advancement in research of diagnostics and therapeutics, cancer is the most dangerous disease‐causing millions of deaths worldwide. Many of the conventional anticancer therapies can even lead to developing resistance to therapy and recurrence of cancer. To find a new, alternative treatment strategy for a variety of ailments scientists and researchers have turned their attention to cell therapies and regenerative medicine. Stem cells are now being researched for their extensive potential application in therapy for several incurable illnesses including cancer. One of the most often employed cell types for regenerative medicine is mesenchymal stem cells. Mesenchymal stem cells (MSCs) are considered a promising source of stem cells in personalized cell‐based therapies. The inherent tumor tropic and immune‐modulatory properties of MSCs can be used to target cancer cells. This review aims to focus on the anticancer properties of MSCs and their effect on different signaling pathways. Later on, we discuss the advantages of engineered MSCs over non‐engineered MSCsin cancer therapy.

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Section: Introductionmentioning

confidence: 99%