Mechanism of ultrasound enhanced porphyrin cytotoxicity: free radical and hematoporphyrin effects

Worthington, A. E.; Thompson, James C.; LaLonde, Robert T.; Patterson, Michael S.; Rauth, Andrew M.; Hunt, J.W.

doi:10.1109/ultsym.1997.661826

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…While ROS-mediated effects are generally accepted as the dominant mechanism underlying SDT, one must account for the inherent sonomechanical effects induced by ultrasound. Ultrasound irradiation alone can hydrodynamically shear cells through acoustic microstreaming, pressure pulse-mediated erosion, and microjetting, all of which can ultimately cause cell membrane disruption. − Initial work conducted by Worthington et al. , supported sonomechanical events leading to SDT effects as opposed to ROS generation. The authors investigated HO· and H· yield through Fricke dosimetry following 1.955 MHz variable intensity ultrasound (where 1.2 W/cm 2 ≈ 0.19 MPa) applied to both water and PBS, with or without hematoporphyrin (Hp), and shaken or tilted to stimulate microbubble formation.…”

Section: Mechanisms Governing Sonodynamic Therapymentioning

confidence: 99%

Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine

2020

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Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadly applicable mechanisms by which acoustic cavitation triggers sonosensitizer therapeutic activity, creating difficulties in achieving substantial and translatable therapeutic efficacy. In this review, we will critically analyze the proposed mechanisms underlying SDT and overview how nanomedicines can complement and extend these mechanisms to deliver more efficacious SDT. In doing so, we aim to highlight potential avenues toward viable implementation of SDT as a cancer therapy.

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Section: Mechanisms Governing Sonodynamic Therapymentioning

confidence: 99%

Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine

2020

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“…Kessel et al [18] suggested that the cytotoxic effect of SDT was mediated largely by inertial cavitation. Inertial cavitation causes a collapse, which produces a shock wave with an intense heat release of several thousand Kelvin [19]. The water molecules surrounding the cavitation phenomena decompose into H°a nd OH°, and their recombination can form H 2 O, H 2 O 2 , and H 2 to directly oxidize or reduce solute molecules, sonosensitizing drugs, or the cell biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Comparing the in vivo sonodynamic effects of dual- and single-frequency ultrasound in breast adenocarcinoma

et al. 2012

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“…Beyond this direct therapeutic action of ROS, an emerging strategy involves utilizing ROS to trigger downstream chemical transformations such as prodrug activation. Alongside the ROS-mediated mechanism, an alternative mechanism explaining the effect of sensitizers under ultrasound suggests that certain sonosensitizers such as porphyrin, − Vitamin E, and Trolox, may embed into lipid membrane bilayers, thereby increasing cellular susceptibility to sonomechanical lysis under acoustic cavitation . Readers are directed to recent review papers for different aspects of SDT such as experimental parameters, mechanisms, , and SDT-based nanomedicines. ,, …”

Section: Sonodynamic Therapy Approaches Toward Prodrug Activationmentioning

confidence: 97%

Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy

Fu,

2024

ACS Appl. Bio Mater.

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Ultrasound has gained prominence in biomedical applications due to its noninvasive nature and ability to penetrate deep tissue with spatial and temporal resolution. The burgeoning field of ultrasound-responsive prodrug systems exploits the mechanical and chemical effects of ultrasonication for the controlled activation of prodrugs. In polymer mechanochemistry, materials scientists exploit the sonomechanical effect of acoustic cavitation to mechanochemically activate force-sensitive prodrugs. On the other hand, researchers in the field of sonodynamic therapy adopt fundamentally distinct methodologies, utilizing the sonochemical effect (e.g., generation of reactive oxygen species) of ultrasound in the presence of sonosensitizers to induce chemical transformations that activate prodrugs. This crossdisciplinary review comprehensively examines these two divergent yet interrelated approaches, both of which originated from acoustic cavitation. It highlights molecular and materials design strategies and potential applications in diverse therapeutic contexts, from chemotherapy to immunotherapy and gene therapy methods, and discusses future directions in this rapidly advancing domain.

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Mechanism of ultrasound enhanced porphyrin cytotoxicity: free radical and hematoporphyrin effects

Cited by 6 publications

References 18 publications

Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine

Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine

Comparing the in vivo sonodynamic effects of dual- and single-frequency ultrasound in breast adenocarcinoma

Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy

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