Abstract:Cold tubulin dimers coexist with tubulin oligomers and single-rings. These structures are involved in microtubule assembly, however, their dynamics are poorly understood. Using state-of-the-art solution synchrotron time-resolved small-angle X-ray scattering we discovered a disassembly catastrophe (half-life of about 0.1 sec) of tubulin rings and oligomers upon dilution or addition of guanosine triphosphate. A slower disassembly (half-life of about 38 sec) was observed following a temperature increase. Our anal… Show more
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