Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma

Craig, Jamie E; Ong, Terrence J; Louis, Damien; Wells, Jane M.

doi:10.1016/s0002-9394(03)00774-8

Cited by 130 publications

(81 citation statements)

References 2 publications

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“…Upper respirator tract infections and cold remedies may have the same effect. 30,73 Posterior segment pathological processes 74 or therapeutic procedures 75 occasionally cause a rise in IOP associated with transient angle [76][77][78] This last observation has prompted Quigley to suggest a choroidal vascular mechanism in some cases of PAC. 79 However, despite the increasing sophistication of our theoretical models of angle closure, we still do not fully understand the reason for closure in many cases.…”

Section: Mechanism Of Angle Closurementioning

confidence: 99%

Angle-closure glaucoma in East Asian and European people. Different diseases?

Foster

Johnson

et al. 2005

Eye

176

102

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In contrast to the pattern of disease in Europeans, primary angle closure has a higher prevalence and tends to be asymptomatic in East Asians. The higher prevalence is attributed to differences in anterior chamber and angle anatomy. Several studies suggest that central anterior chamber depth is shallower in East Asians than in Europeans, although this is not universally accepted. It is debated whether pupil block is the predominant mechanism of angle closure in Asian people. Meaningful comparison between studies is currently hindered by differences in patient selection, examination technique, and case definition; however, the major scientific deficiency is the paucity of prospective followup data to give an insight into natural history of the disease. This review examines the data on prevalence, risk factors, and mechanism of angle closure. Special consideration is given to limitations of methodology in research to date, with the intention of developing more robust data in future studies.

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Section: Mechanism Of Angle Closurementioning

confidence: 99%

Angle-closure glaucoma in East Asian and European people. Different diseases?

Foster

Johnson

et al. 2005

Eye

176

102

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“…To date, the mechanisms underlying the ocular side effects associated with topiramate treatment have not be determined (6). However, some have suggested that these side effects are the result of ciliary body edema and anterior displacement of the ciliary processes (7).…”

Section: Discussionmentioning

confidence: 99%

Düşük Doz Topi̇ramat Kullanimi Sonrasi Geli̇şen Bi̇lateral Akut Dar Açili Glokom Ve Mi̇yopi̇

2015

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ÖZETGiriş: Topiramat, epilepsi tedavisinde ve migren profilaksisinde etkili olduğu gösterilen sülfamat sübstitüsyonlu monosakkarid türevi bir ajandır. Bu ilacın kullanımı sırasında özellikle ilk iki hafta içerisinde akut myopi ile birlikte açı kapanması glokomu krizi gelişebilir.Olgu: Bu olgu sunumunda aurasız migren profilaksisi nedeniyle bir haftadır topiramat 25 mg/gün kullanımı sonrası açı kapanması glokomu ve akut myopi gelişen 23 yaşında bayan hasta tartışılmıştır. Görme kaybı, gözlerde kızarıklık ve yanma şikayetiyle başvuran hastanın yapılan oftalmolojik muayenesinde her iki gözde belirgin konjonktival hiperemi, sığ ön kamara, iriste bombeleşme ve her iki gözde grade 1 dar açı saptandı. Intraoküler basınç her iki gözde 40 mmHg idi. Her iki gözde refraksiyon değerleri -7,00 ve -8,00 olarak saptandı. Hastanın görme keskinliği seviyeleri 0,1 ile 0,2 düzeyindeydi. Diğer nörolojik muayene bulguları normal olarak değerlendirildi. Hastanın almakta olduğu topiramat tedavisi kesildi ve topikal antiglokomatöz ilaç tedavisi başlandı ve her iki göze periferal iridotomi yapıldı. On gün sonraki oftalmolojik muayenesi tamamen normaldi.Yorum: Topiramat kullanımına bağlı bu yan etkinin erken saptanması sonrasında ilacın kesilmesi ve antiglokomatöz tedavi ile , oluşan tüm bulguların hasar bırakmaksızın ortadan kalktığı bilinmektedir. Bu yüzden özellikle topiramat tedavisi başlandıktan sonraki ilk haftalarda hastaların ve hekimlerin göz bulguları açısından dikkatli olmaları gerekmektedir.Anahtar sözcükler: Glokom, migren, miyopi, topiramat ABSTRACT Introduction:Topiramate, a sulfamate-substituted monosaccharide, has been shown to be effective in the treatment of epilepsy and migraine prophylaxis. However, acute secondary angle closure glaucoma and myopia has been shown to develop, especially during the first two weeks of treatment, in a small subset of patients.Case presentation: In the current case report, a 23 year old female patient developed acute myopia and angle closure glaucoma after one week topiramate treatment (25 mg/day) for prophylaxis of migraine without aura. The patient was found to have significant conjunctival hyperemia, shallow anterior chamber, and bulging iris in both eyes. Grade 1 acute angle was detected in both eyes during gonioscopic examination. There was no pupillary block and intraocular pressure was 40 mmHg in both eyes. Refraction values were measured at -7.00 and -8.00 in the right and left eye, respectively. The patient's visual acuity was at 0.1 to 0.2.Topiramate treatment was promptly discontinued, topical antiglaucomatous treatment was initiated, and laser peripheral iridotomy was performed on each eye. Intraocular pressure has declined to normal limits, refractive values were zero in both eyes and patient's visual acuity has restored at follow-up period at 10 days after treatment.Conclusion:Side effects associated with topiramate treatments are known to disappear without long-term damage when the discontinuation of therapy and effective interventions are started early. Therefore, patients...

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“…Alguns autores acreditam que o processo acontece por efusão uveal devido à edema do corpo ciliar, com consequente anteriorização do diafragma irido-cristaliniano, levando à diminuição da profundidade da câmara anterior e fechamento do seio camerular, sem bloqueio pupilar (7) . A efusão uveal induzida por drogas é extremamente rara, embora tenha sido relatada também com o uso de derivados das sulfas, como a acetazolamida, hidroclortiazida, sulfametoxazol e os inibidores seletivos da recaptação de serotonina.…”

Section: Discussionunclassified

Miopia aguda induzida por topiramato: relato de dois casos

Sgrott¹,

Silva²,

Hagemann³

et al. 2011

Rev. bras.oftalmol.

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RESUMOA miopia aguda pode ser desencadeada pelo uso de medicações sistêmicas, dentre elas, o anticonvulsivante topiramato. Este trabalho descreve dois casos de pacientes jovens com quadro agudo bilateral de miopia induzida por terapia com topiramato para controle de síndrome depressiva, fazendo relação com casos semelhantes descritos na literatura e revisão bibliográfica pertinente.Descritores: Miopia/induzido quimicamente; Anticonvulsivantes/efeitos adversos; Relatos de casos Recebido para publicação em: 26/10/2009 -Aceito para publicação em 28/6/2011 ABSTRACT

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Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma

Cited by 130 publications

References 2 publications

Angle-closure glaucoma in East Asian and European people. Different diseases?

Angle-closure glaucoma in East Asian and European people. Different diseases?

Düşük Doz Topi̇ramat Kullanimi Sonrasi Geli̇şen Bi̇lateral Akut Dar Açili Glokom Ve Mi̇yopi̇

Miopia aguda induzida por topiramato: relato de dois casos

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