Mechanism of Thymus- and Activation-Regulated Chemokine (TARC)/CCL17 Production and its Modulation by Roxithromycin

Komine, Mayumi; Kakinuma, Takashi; Kagami, Shinji; Hanakawa, Yasushi; Hashimoto, Koji; Tamaki, Kunihiko

doi:10.1111/j.0022-202x.2005.23840.x

Cited by 53 publications

(49 citation statements)

References 53 publications

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“…TARC can be produced by airway epithelial cells (30), but very little is known about how TARC production is regulated. For the human gene, two transcription factors have been shown to play a role in TARC production, NFB and STAT6 (31,32). In contrast to TARC, IFN-␥-inducible protein 10 (IP-10)/ CXCL10 is a chemokine that preferentially attracts Th1 T cells via the receptor CXCR3.…”

Section: R Espiratory Syncytial Virus (Rsv)mentioning

confidence: 99%

Respiratory Syncytial Virus Synergizes with Th2 Cytokines to Induce Optimal Levels of TARC/CCL17

Monick

Powers

Hassan

et al. 2007

The Journal of Immunology

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Respiratory syncytial virus (RSV) is a ubiquitous virus that preferentially infects airway epithelial cells, causing asthma exacerbations and severe disease in immunocompromised hosts. Acute RSV infection induces inflammation in the lung. Thymus- and activation-regulated chemokine (TARC) recruits Th2 cells to sites of inflammation. We found that acute RSV infection of BALB/c mice increased TARC production in the lung. Immunization of BALB/c mice with individual RSV proteins can lead to the development of Th1- or Th2-biased T cell responses in the lung after RSV infection. We primed animals with a recombinant vaccinia virus expressing either the RSV fusion (F) protein or the RSV attachment (G) protein, inducing Th1- and Th2-biased pulmonary memory T cell responses, respectively. After RSV infection, TARC production significantly increased in the vaccinia virus G-primed animals only. These data suggest a positive feedback loop for TARC production between RSV infection and Th2 cytokines. RSV-infected lung epithelial cells cultured with IL-4 or IL-13 demonstrated a marked increase in the production of TARC. The synergistic effect of RSV and IL-4/IL-13 on TARC production reflected differential induction of NFκB and STAT6 by the two stimuli (both are in the TARC promoter). These findings demonstrate that RSV induces a chemokine TARC that has the potential to recruit Th2 cells to the lung.

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Section: R Espiratory Syncytial Virus (Rsv)mentioning

confidence: 99%

Respiratory Syncytial Virus Synergizes with Th2 Cytokines to Induce Optimal Levels of TARC/CCL17

Monick

Powers

Hassan

et al. 2007

The Journal of Immunology

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“…The Janus family of tyrosine kinases (Jaks) is an integral factor in IFN-γ activated signaling cascades and regulates tyrosine phosphorylation of the STAT proteins. STAT protein translocation to the nucleus and binding to IFN-γ activated sequences (GAS) is a crucial component of IFN-γ signaling (Komine et al, 2005;Best et al, 2005). Also, the JAK-STAT signaling pathway is the important pathway for IFN-γ signal transduction in HaCaT human keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

“…IFN-γ activates the JAK-STAT path-way, STAT, ERK, and p38 MAP kinases (Komine et al, 2005). IFN-γ and TNF-α activate Jak1/Jak2 and Jak1/ Tyk2, respectively.…”

Section: Introductionmentioning

confidence: 99%

Prunus Yedoensis Inhibits the Inflammatory Chemokines, MDC and TARC, by Regulating the STAT1-Signaling Pathway in IFN-γ-stimulated HaCaT Human Keratinocytes

Kang

Lee

Yoon

et al. 2008

Biomolecules and Therapeutics

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− Atopic dermatitis (AD) is an inflammatory skin disease commonly characterized by infiltration of inflammatory cells into skin lesions. Keratinocytes produce many chemokines that are involved in the pathogenesis of skin disorders. In particular, macrophage-derived chemokine (MDC/CCL22) and thymus and activationregulated chemokine (TARC/CCL17) are Th2-type cytokines. Serum MDC and TARC levels are increased in AD patients. In this study, we investigated the anti-inflammatory effect and mechanism of action of the active fraction from Prunus yedoensis bark. We evaluated their inhibitory effects on the AD-like inflammatory markers (MDC and TARC) and JAK-STAT pathway (STAT1) in HaCaT keratinocytes. The EtOAc fraction of the crude extract (80% EtOH) and the E5 sub-fraction potently inhibited the induction of MDC and TARC mRNA and protein at 50 µg/mL in HaCaT cells. In addition, the E5 sub-fraction inhibited the phosphorylation of STAT1 protein associated with IFN-γ signaling transduction in a dose-dependent manner. Thus, P. yedoensis may have antiatopic activity by suppressing the inflammatory chemokines (MDC and TARC).

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“…TSLP timustan salgılanır ve zaman zaman monosit türevli dendritik hücreler ve endotel hücreleri tarafından üretilir (7,8) . TARC derideki keratinositlerden salgılanır ve T hücre kemotaksisini indükler (9) .…”

Section: Introductionunclassified

The relationship between serum TSLP and TARC levels with the severity of atopic dermatitis in infants

Birtekocak¹,

Uysal²,

Karul³

2016

Buch

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ÖZAmaç: Atopik dermatit tanılı sütçocuklarında serum TSLP ve TARC düzeylerinin ölçülmesi, hastalığın ağırlığı ile ilişkisinin araştırılması ve elde edilen sonuçların sağlıklı çocukların değer-leri ile karşılaştırılması amaçlanmıştır. Yöntemler: Atopik dermatitin ağırlığı SCORing atopik dermatitis score (SCORAD) ile belirlendi. Atopik dermatitli çocuklarda atopik durumun değerlendirilmesi için deri prik testi uygulandı. Tüm katılımcılarda serum TSLP ve TARC düzeyi ölçüldü. Bulgular: Atopik dermatitli çocukların serum TSLP ve TARC düzeyleri sağlıklı kontrollerin değerlerinden anlamlı olarak yüksekti (sırasıyla, p=0,001, p=0,004). Atopik dermatitin ağırlığı ile serum TARC düzeyleri arasında ilişki var iken (p=0,014), TSLP ile hastalığın ağırlığı arasın-da ilişki saptanmadı (p=0,80). Atopik dermatitli çocuklarda TSLP ve TARC arasında korrelasyon saptanmaz iken (p=0,576), TARC ile hastanın yaşı arasında negatif yönde orta düzeyde korrelasyon saptandı (r= -0,426, p=0,038). Receiver operating characteristic (ROC) analizinde serum TSLP düzeyinin atopik dermatit varlığını öngörmesi için hesaplanan Eğri Altında Kalan Alan (Area Under Curve, AUC) 0,780 [%95 Güven Aralığı (0,640 -0,885) p<0,001] bulundu. Serum TSLP 30,41 pg/mL düzeyinin atopik dermatit varlığını öngörmede duyarlılığı %72 ve özgüllüğü %84 olarak saptandı. Serum TARC düzeyinin atopik dermatit varlığını öngörmesi için hesaplanan AUC 0,738 [%95 Güven Aralığı (0,595-0,852) p=0,0007] bulundu. Serum TARC 242,68 pg/mL düzeyinin atopik dermatit varlığını öngörmede duyarlılığı %72 ve özgüllüğü %68 bulundu. Sonuç: Serum TSLP ve TARC düzeyleri sütçocuklarında atopik dermatit varlığı ile yakından ilişkilidir. Serum TARC düzeyi atopik dermatit ağırlığı ile ilişkilidir. Anahtar kelimeler: Atopik dermatit, TSLP, TARC ABSTRACTObjective: The aim of the study is to measure serum levels of TSLP and TARC, to evaluate their relationships with disease severity and to compare the results with the levels of healthy children. Methods: The severity of atopic dermatitis was determined by scoring atopic dermatitis score (SCORAD). Skin prick test was performed to evaluate atopic status. Serum TSLP and TARC levels were measured in all participants. Results: Serum levels of TSLP and TARC were significantly higher in children with atopic dermatitis than those of healthy controls (p=0.001, p=0.004, respectively). While, there was an association between disease severity and serum TARC levels (p=0.014), no association was found between TSLP, and severity of disease (p=0.80). There was no correlation between TSLP and TARC (p=0.576), however, TARC was negatively correlated with age of the children with atopic dermatitis (r= -0.426, p=0.038). In receiver operating characteristic (ROC) analysis, area under Curve (AUC) which was calculated serum TSLP level in the prediction of the presence of atopic dermatitis was 0.780 [95% confidence interval (0.640-0.885), p<0.001]. The sensitivity of serum TSLP level of 30,41 pg/mL was 72% and the specificity 84% in the prediction of the presence of atopic der...

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Mechanism of Thymus- and Activation-Regulated Chemokine (TARC)/CCL17 Production and its Modulation by Roxithromycin

Cited by 53 publications

References 53 publications

Respiratory Syncytial Virus Synergizes with Th2 Cytokines to Induce Optimal Levels of TARC/CCL17

Respiratory Syncytial Virus Synergizes with Th2 Cytokines to Induce Optimal Levels of TARC/CCL17

Prunus Yedoensis Inhibits the Inflammatory Chemokines, MDC and TARC, by Regulating the STAT1-Signaling Pathway in IFN-γ-stimulated HaCaT Human Keratinocytes

The relationship between serum TSLP and TARC levels with the severity of atopic dermatitis in infants

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