Mechanism of the immunostimulatory activity by a polysaccharide from Dictyophora indusiata

Deng, Chao; Shang, Jingying; Fu, Haitian; Chen, Jingxiao; Liu, Hanying; Chen, Jinghua

doi:10.1016/j.ijbiomac.2016.06.024

Cited by 57 publications

(33 citation statements)

References 40 publications

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“…The study by Fu et al [44] on immunestimulatory effect of the polysaccharides were similar with the above studies by Deng et al [20,38]. They have shown however that the purified polysaccharide of β-(1→3)-glucan with side branches of β-(1→6)-glucosyl unit had a triple-helical structure.…”

Section: Immunostimulationsupporting

confidence: 77%

“…The immunestimulatory effect of D. indusiata polysaccharides has been demonstrated in unstimulated macrophages in vitro. Treatment of the murine RAW264.7 cells with these polysaccharides could induce a proliferative response while markers of macrophage activation such as cytokines (IL-1β, IL-6 and TNF-α), NO synthase (level of NO) and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) p65 were upregulated [38]. Moreover, macrophage activation by these polysaccharides could be attributed to the toll-like receptor 4 (TLR4) since the observed activity could be abolished by anti-TLR4 and anti-CR3 mAbs.…”

Section: Immunostimulationmentioning

confidence: 99%

See 1 more Smart Citation

The Chemistry, Pharmacology and Therapeutic Potential of the Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer (Synn. Phallus indusiatus)

Habtemariam

2019

Biomedicines

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Dictyophora indusiata (Vent. Ex. Pers.) Fischer or Phallus indusiatus is an edible member of the higher mushroom phylum of Basidiomycetes. Known for its morphological elegance that gave it the names bridal veil fungus, veiled lady or queen of the mushrooms, it has numerous medicinal values that are beginning to be acknowledged through pharmacological efficacy studies. In an attempt to promote research on this valuable natural resource, the present communication aims to provide a comprehensive review of the chemistry, pharmacology and potential therapeutic applications of extracts and compounds isolated from D. indusiata. Of the bioactive compounds, the chemistry of the polysaccharides as major bioactive components primarily the β-(1→3)-D-glucan with side branches of β-(1→6)-glucosyl units are discussed, while small molecular weight compounds include terpenoids and alkaloids. Biochemical and cellular mechanisms of action from general antioxidant and anti-inflammatory to more specific signaling mechanisms are outlined along with potential applications in cancer and immunotherapy, neurodegenerative and chronic inflammatory diseases, etc. Further research areas and limitations of the current scientific data are also highlighted.Biomedicines 2019, 7, 98 2 of 21 have been reported [3]. The composition of carbohydrates can reach up to 47% of the dry weight of which the soluble polysaccharides are about 38%, while crude fibres and crude proteins contents are about 29% and 6% respectively [1]. In this communication, the emphasis is on the compositions of the fruiting body far beyond nutritional source with a focus on their pharmacologically active components and their therapeutic implications. In this connection, considerable attention has been given to the major components of the fungus, the polysaccharides, while small molecular weight drug-like molecules such as terpenoids and alkaloids have not been extensively studied. The chemistry and biological significance of all the bioactive compounds known from D. indusiata are herein scrutinised.Biomedicines 2020, 8, x FOR PEER REVIEW 2 of 21 have been reported [3]. The composition of carbohydrates can reach up to 47% of the dry weight of which the soluble polysaccharides are about 38%, while crude fibres and crude proteins contents are about 29% and 6% respectively [1]. In this communication, the emphasis is on the compositions of the fruiting body far beyond nutritional source with a focus on their pharmacologically active components and their therapeutic implications. In this connection, considerable attention has been given to the major components of the fungus, the polysaccharides, while small molecular weight drug-like molecules such as terpenoids and alkaloids have not been extensively studied. The chemistry and biological significance of all the bioactive compounds known from D. indusiata are herein scrutinised.

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Section: Immunostimulationsupporting

confidence: 77%

Section: Immunostimulationmentioning

confidence: 99%

The Chemistry, Pharmacology and Therapeutic Potential of the Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer (Synn. Phallus indusiatus)

Habtemariam

2019

Biomedicines

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“…This mushroom has a cosmopolitan distribution and has been consumed in a variety of folklore situations by ethnic groups [ 48 , 49 ]. Beside other components, polysaccharides isolated from the fruiting body of D. indusiata have been reported to show considerable bioactivities, such as immunostimulatory [ 50 ], anticancer [ 51 ], antioxidant [ 52 ], neuroprotective [ 53 ], and antiproliferative activities [ 54 ]. However, to the best of our knowledge, its effect on the gut microbial ecosystem and gut barrier function remain unknown.…”

Section: Introductionmentioning

confidence: 99%

A Polysaccharide Isolated from Dictyophora indusiata Promotes Recovery from Antibiotic-Driven Intestinal Dysbiosis and Improves Gut Epithelial Barrier Function in a Mouse Model

et al. 2018

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Despite the tremendous biological activity of polysaccharides from the mushroom Dictyophora indusiata, its role in the restoration of gut microbiota has not yet been explored. The present study aimed to investigate whether D. indusiata polysaccharide (DIP) could modulate the recovery of gut microbiota composition and intestinal barrier function after broad-spectrum antibiotic-driven dysbiosis. Alteration and restoration in the microbial communities were elucidated by the Illumina MiSeq platform. Colon histology, expression of tight-junction associated proteins, and serum/tissue endotoxin and cytokine levels were evaluated. Two-week daily oral administration of clindamycin and metronidazole resulted in reduced bacterial diversity and richness, and perturbed the microbial flora at various taxonomic levels (altered Firmicutes/Bacteroidetes ratio and increased relative abundance of harmful flora (Proteobacteria, Enterococcus, and Bacteroides)), whereas DIP administration reversed the dysbiosis and increased beneficial flora, including Lactobacillaceae (lactic acid-producing bacteria), and Ruminococaceae (butyrate-producing bacteria). In addition, it resulted in the reduction of endotoxemia (through lipopolysaccharides (LPSs)) and pro-inflammatory cytokine (tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1β (IL-1β)) levels, with the increased expression of tight-junction associated proteins (claudin-1, occludin, and zonula occludens-1). These findings not only suggested a comprehensive understanding of the protective effects of a DIP in the restoration of gut microbiota but also highlighted its role in the enhancement of gut barrier integrity, reduction of inflammation and lowering of endotoxin levels in mice.

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“…Recently, studies have demonstrated that polysaccharides have various bioactive properties and can potentially impede the function of macrophages (Deng et al, 2016). In particular, polysaccharides from edible mushrooms have attracted the interest of a wide range of researchers.…”

Section: Introductionmentioning

confidence: 99%

“…A medium-to-high molecular weight exopolysaccharide from Schizophyllum commune was shown to have intestinal anti-inflammatory activity (Du, Yang, Bian, & Xu, 2017). The polysaccharides from Dictyophora indusiata significantly affected macrophage immune function by promoting the secretion of NO and pro-inflammatory cytokines, including IL-1, -6, -12 and TNF-α (Deng et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways

Chen

Gong

et al. 2018

Food and Agricultural Immunology

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Immune-enhancing effects of a polysaccharide PRG1-1 from Russulagriseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways, Food and Agricultural Immunology, 29:1, 833-844, ABSTRACTPolysaccharides are one of many bioactive compounds found in edible mushrooms. Edible mushrooms have become attractive as "health foods" and as source materials for immunomodulators. The aim of this project was to study the immunoregulatory effects of a purified polysaccharide derived from wild Russula griseocarnosa (PRG1-1) on macrophages. Our data showed that in RAW264.7 macrophage cells, PRG1-1 increased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, PRG1-1 increased the production of nitric oxide (NO) and cytokines, including interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-α). Western blotting demonstrated that the regulation of NO and cytokines was mediated through the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways. Therefore, PRG1-1 has the capacity to activate macrophages via the NF-κB and MAPK pathways. These findings helped to elucidate the immunemodulatory properties of the polysaccharide from R. griseocarnosa. ARTICLE HISTORY

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Mechanism of the immunostimulatory activity by a polysaccharide from Dictyophora indusiata

Cited by 57 publications

References 40 publications

The Chemistry, Pharmacology and Therapeutic Potential of the Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer (Synn. Phallus indusiatus)

The Chemistry, Pharmacology and Therapeutic Potential of the Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer (Synn. Phallus indusiatus)

A Polysaccharide Isolated from Dictyophora indusiata Promotes Recovery from Antibiotic-Driven Intestinal Dysbiosis and Improves Gut Epithelial Barrier Function in a Mouse Model

Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways

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