Mechanism of the Formation of Electronically Excited Species by Oxidative Metabolic Processes: Role of Reactive Oxygen Species

Pospı́šil, Pavel; Prasad, Ankush; Rác, Marek

doi:10.3390/biom9070258

Cited by 71 publications

(62 citation statements)

References 150 publications

(180 reference statements)

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“…•− and • OH [21]. Attenuated or transient alterations in the cellular redox state occur in response to ROS accumulation in stressed cells.…”

Section: Overview Of Principal Subcellular Compartments Involved In Rmentioning

confidence: 99%

“…Despite containing an O 2 •− pool of less than 0.5%, the protonated superoxide radical HO 2 • , also called a hydroperoxyl or perhydroxyl radical, is comparatively more toxic [23]. 1 O 2, another toxic ROS species, is an electronically excited O 2 generated in chloroplasts [21], which is regulated by an antioxidant located close to each ROS production site. This system has two main functions: to avoid potential oxidative damage and to perform signaling processes, especially in the case of H 2 O 2 and NO.…”

Section: Overview Of Principal Subcellular Compartments Involved In Rmentioning

confidence: 99%

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Assessment of Subcellular ROS and NO Metabolism in Higher Plants: Multifunctional Signaling Molecules

et al. 2019

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Reactive oxygen species (ROS) and nitric oxide (NO) are produced in all aerobic life forms under both physiological and adverse conditions. Unregulated ROS/NO generation causes nitro-oxidative damage, which has a detrimental impact on the function of essential macromolecules. ROS/NO production is also involved in signaling processes as secondary messengers in plant cells under physiological conditions. ROS/NO generation takes place in different subcellular compartments including chloroplasts, mitochondria, peroxisomes, vacuoles, and a diverse range of plant membranes. This compartmentalization has been identified as an additional cellular strategy for regulating these molecules. This assessment of subcellular ROS/NO metabolisms includes the following processes: ROS/NO generation in different plant cell sites; ROS interactions with other signaling molecules, such as mitogen-activated protein kinases (MAPKs), phosphatase, calcium (Ca2+), and activator proteins; redox-sensitive genes regulated by the iron-responsive element/iron regulatory protein (IRE-IRP) system and iron regulatory transporter 1(IRT1); and ROS/NO crosstalk during signal transduction. All these processes highlight the complex relationship between ROS and NO metabolism which needs to be evaluated from a broad perspective.

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“…•− and • OH [21]. Attenuated or transient alterations in the cellular redox state occur in response to ROS accumulation in stressed cells.…”

Section: Overview Of Principal Subcellular Compartments Involved In Rmentioning

confidence: 99%

Section: Overview Of Principal Subcellular Compartments Involved In Rmentioning

confidence: 99%

Assessment of Subcellular ROS and NO Metabolism in Higher Plants: Multifunctional Signaling Molecules

et al. 2019

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“…The lipid peroxidation in the biological membranes is the most obvious symptoms visible in plants as an outcome of oxidative stress in plants (Jarvis, 2011;Kumar et al, 2018;Zhang et al, 2018). The high energy intermediates (dioxetanes and tetroxide) formed during the oxidative radical reactions decompose to triplet carbonyls ( 3 C=O*) which can then transfer triplet energy to molecular oxygen creating 1 O 2 (Di Mascio et al, 1992;Miyamoto et al, 2003;Miyamoto et al, 2007;Cifra and Pospíšil, 2014;Pospíšil et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species as a Response to Wounding: In Vivo Imaging in Arabidopsis thaliana

et al. 2020

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Mechanical injury or wounding in plants can be attributed to abiotic or/and biotic causes. Subsequent defense responses are either local, i.e. within or in the close vicinity of affected tissue, or systemic, i.e. at distant plant organs. Stress stimuli activate a plethora of early and late reactions, from electric signals induced within seconds upon injury, oxidative burst within minutes, and slightly slower changes in hormone levels or expression of defense-related genes, to later cell wall reinforcement by polysaccharides deposition, or accumulation of proteinase inhibitors and hydrolytic enzymes. In the current study, we focused on the production of reactive oxygen species (ROS) in wounded Arabidopsis leaves. Based on fluorescence imaging, we provide experimental evidence that ROS [superoxide anion radical (O 2 •−) and singlet oxygen (1 O 2)] are produced following wounding. As a consequence, oxidation of biomolecules is induced, predominantly of polyunsaturated fatty acid, which leads to the formation of reactive intermediate products and electronically excited species.

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“…These enzymes are present in almost all aerobic cells and in extracellular fluids. SODs contain metal ion cofactors that, depending on the isozyme, can be copper, zinc, manganese, or iron [ 93 , 94 ]. There are three isozymes in humans.…”

Section: Oxidative Stressmentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka

Vécsei

2020

Biomedicines

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Worldwide, over 2.2 million people suffer from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by a wide range of motor, autonomic, and psychobehavioral symptoms, including depression, anxiety, and dementia. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients provide evidence on the disturbance of reduction-oxidation (redox) homeostasis, such as the alterations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discusses the components of redox homeostasis, including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species cover frequently discussed reactive oxygen/nitrogen species, infrequently featured reactive chemicals such as sulfur, carbonyl, halogen, selenium, and nucleophilic species that potentially act as reductive, as well as pro-oxidative stressors. The antioxidative enzyme systems cover the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. The NRF2 and other transcriptional factors potentially become a biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed in search of a diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring the battery of reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products helps to evaluate the redox status of MS patients to expedite the building of personalized treatment plans for the sake of a better quality of life.

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Mechanism of the Formation of Electronically Excited Species by Oxidative Metabolic Processes: Role of Reactive Oxygen Species

Cited by 71 publications

References 150 publications

Assessment of Subcellular ROS and NO Metabolism in Higher Plants: Multifunctional Signaling Molecules

Assessment of Subcellular ROS and NO Metabolism in Higher Plants: Multifunctional Signaling Molecules

Reactive Oxygen Species as a Response to Wounding: In Vivo Imaging in Arabidopsis thaliana

Monitoring the Redox Status in Multiple Sclerosis

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