Mechanism of taurine reducing inflammation and organ injury in sepsis mice

Ma, Yuan; Zhang, Yue; Li, Rui; Deng, Shuwei; Qin, Qiushi; Ran, Chongping; Yu, Han‐Qing; Zhang, Jianping; Zhu, Linyu

doi:10.1016/j.cellimm.2022.104503

Cited by 11 publications

(8 citation statements)

References 47 publications

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“…Taurine is involved in the maintenance of neutrophil redox homeostasis and exerts antiinflammatory effects by reducing cytokine release 36 . In septic model, taurine improves tissue injuries through reducing neutrophil infiltration and TNF-α production 37 . In addition, gut microbiota-produced taurine shields hostmicrobiota interface that potentiates resistance to pathogens infection 38 .…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

Liu

Sui

et al. 2023

Preprint

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Hypertriglyceridemic pancreatitis (HTGP) is featured by higher incidence of complications and poor outcomes. Dysbiosis of gut microbiota has been established in HTGP, the impact of gut microbiota in pancreatic injury remains unclear. We observed that HTGP patients’ gut microbiota involved lower diversity and loss of beneficial bacteria, which were negatively correlated with local and systemic complications. In FMT mouse model, colonization with gut microbiota from HTGP patients exacerbated pancreatic injury through inducing neutrophil infiltration and neutrophil extracellular traps (NETs) compared to mice colonized with health volunteers’ fecal samples. Furthermore, decreased Bacteroides uniformis was demonstrated to trigger neutrophils accumulation and NETs release in HTGP, and oral administration of Bacteroides uniformis increased taurine production that alleviated pancreatic injury. In addition, taurine supplementation limited neutrophils infiltration and NETs that attenuated pancreatic injury. Notably, circulating NETs-related biomarker levels were elevated in HTGP patients and coculturing patients’ serum with neutrophils accelerated NETs release in vitro, accompanying with taurine-producing disorder. Our ﬁndings establish roles of endogenous Bacteroides uniformis-derived taurine suppressed neutrophils recruitments and NETs in HTGP, which provides potential insights of ameliorating pancreatic injury by gut microbiota modulation.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

Liu

Sui

et al. 2023

Preprint

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“…Taurine as an antioxidant plays significant roles in preventing oxidative stress, scavenging reactive oxygen species (ROS), and anti-inflammatory activity. 48 Here, the MALDI-MSI data show that the level of taurine presented an upregulated expression in Jurkat cocultured spheroids (Figure S3C). Glutamate, which shapes the acidic TME and can alter the immune function of T cells, 49 was also upregulated during coculture (Figure S3D).…”

Section: Bbr Boosts Antitumor Immune Responses the Interaction Betwee...mentioning

confidence: 70%

Spatially Resolved Metabolomics Combined with the 3D Tumor-Immune Cell Coculture Spheroid Highlights Metabolic Alterations during Antitumor Immune Response

Chen,

Han,

Wang

et al. 2023

Anal. Chem.

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The metabolic cross-talk between tumor and immune cells plays key roles in immune cell function and immune checkpoint blockade therapy. However, the characterization of tumor immunometabolism and its spatiotemporal alterations during immune response in a complex tumor microenvironment is challenging. Here, a 3D tumor-immune cell coculture spheroid model was developed to mimic tumor-immune interactions, combined with mass spectrometry imaging-based spatially resolved metabolomics to visualize tumor immunometabolic alterations during immune response. The inhibition of T cells was simulated by coculturing breast tumor spheroids with Jurkat T cells, and the reactivation of T cells can be monitored through diminishing cancer PD-L1 expressions by berberine. This system enables simultaneously screening and imaging discriminatory metabolites that are altered during T cell-mediated antitumor immune response and characterizing the distributions of berberine and its metabolites in tumor spheroids. We discovered that the transport and catabolism of glutamine were significantly reprogrammed during the antitumor immune response at both metabolite and enzyme levels, corresponding to its indispensable roles in energy metabolism and building new biomass. The combination of spatially resolved metabolomics with the 3D tumor-immune cell coculture spheroid visually reveals metabolic interactions between tumor and immune cells and possibly helps decipher the role of immunometabolic alterations in tumor immunotherapy.

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“…Low levels of nuclear p21 in ovarian tumors correlate with tumor cell proliferation and reduced progression-free interval for patients 10-13 . Platinum-based chemotherapy, a standard approach to treat OC 53 , can activate p21 and arrest the cell cycle in OC cells 54,55 ; however, due to overt cell toxicities and emerging chemotherapy resistance, the treatment is temporary, and, in most cases, surviving tumor cells regain the ability to proliferate and cause disease progression. In this study, we provide evidence that supplementation of OC cell cultures with the dietary supplement taurine activates cell-cycle control without causing cytotoxicity in OC cells expressing Wild Type p53 protein or various full-length mutant p53 proteins.…”

Section: Discussionmentioning

confidence: 99%

Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-damage-sensing-dependent Cell Protection

Centeno

Farsinejad

Кочеткова

et al. 2023

Preprint

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Loss of treatment-induced ovarian carcinoma (OC) growth suppression poses a major clinical challenge because it leads to disease recurrence. Therefore, new and well-tolerated approaches to maintain OC suppression after standard-of-care treatment are needed. We have profiled ascites as OC tumor microenvironments (TMs) to search for potential components that would exert growth suppression on OC cell cultures. Our investigations revealed that low levels of taurine, a non-proteogenic sulfonic amino acid, were present within OC ascites. Taurine supplementation, beyond levels found in ascites, induced growth suppression without causing cytotoxicity in multiple OC cell cultures, including patient-derived chemotherapy-resistant spheroid and organoid cultures. Suppression of proliferation by taurine was associated with the inhibition of glycolysis, mitochondrial function, and the activation of p21 and TIGAR, theTP53-dependent and independent tumor suppression regulatory pathways. Expression of p21 or TIGAR in various OC cells, in part, mimicked taurine-induced inhibition of OC cell proliferation. Our data support the potential therapeutic value of taurine supplementation in OC after chemotherapy.

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Mechanism of taurine reducing inflammation and organ injury in sepsis mice

Cited by 11 publications

References 47 publications

WITHDRAWN: Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

WITHDRAWN: Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

Spatially Resolved Metabolomics Combined with the 3D Tumor-Immune Cell Coculture Spheroid Highlights Metabolic Alterations during Antitumor Immune Response

Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-damage-sensing-dependent Cell Protection

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