For several decades, mainstream criminology has been dominated by sociological and political perspectives. Although findings from these fields must not be discarded or underplayed, considered alone, they do not offer a complete assessment of the contributions to criminal behavior. Data currently being generated from numerous behavioral sciences, such as behavioral genetics, physiological psychology, psychopharmacology, and endocrinology, indicate that biological factors play an equally significant role in the development of antisocial behavior and should be considered accordingly. Incorporation of the theoretical parameters and findings of these behavioral sciences into a criminological framework would yield valuable in formation regarding processes underlying antisocial behavior. Such a multidisciplinary approach is likely to enhance capabilities to predict, prevent, and manage antisocial behavior. Theoretical parameters, methodological issues, selected research findings, potential applications, and precautions are discussed.