Mechanism of Sperm Migration

Moghissi, Kamran S.; Dabich, Danica; Levine, Jacob B.; Neuhaus, Otto W.

doi:10.1016/s0015-0282(16)35103-2

Cited by 42 publications

(8 citation statements)

References 14 publications

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“…More recent studies, however, have shown that the motility of the female genital tract, not of the spermatozoa, plays the major role in sperm transport. The innate movement of the spermatozoa appears to be of critical importance only in passing through structural barriers such as the cervix (Moghissi, Dabich, Levine & Neuhaus, 1964) and possibly the utero-tubal junction (Leonard & Perlman, 1949).…”

Section: Introductionmentioning

confidence: 99%

Enhanced and co-ordinated movement of the hamster oviduct during the periovulatory period

Battalia¹,

Yanagimachi²

1979

Reproduction

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The movement of the hamster oviduct in vivo was examined after injection of a small quantity of India ink into the lowermost region of the isthmus. An active and co-ordinated movement of both the isthmus and ampulla that caused a rapid transport of the ink to the upper ampulla (and eventually to the ovarian bursa) was observed shortly before, during and within a few hours after ovulation. During the rest of the oestrous cycle, no ink was transported to the upper ampulla despite active contractile movement by the isthmus. These observations suggest that the oviduct as a whole exhibits an efficient contractile movement suited for sperm transport only during the periovulatory period.

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Section: Introductionmentioning

confidence: 99%

Enhanced and co-ordinated movement of the hamster oviduct during the periovulatory period

Battalia¹,

Yanagimachi²

1979

Reproduction

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“…Plasmin inhibitors were reported to delay liquefaction of semen, and both trypsin and plasmin inhibitors reduce sperm motility ( Matsuda et al ., 1994 ). Furthermore, trypsin and chymotrypsin have been detected in both cervical mucus and semen ( Neuhaus & Moghissi, 1962; Moghissi et al ., 1964 ).…”

Section: Resultsmentioning

confidence: 99%

Enzymatic treatment of spermatozoa with a trypsin solution, SpermSolute: improved motility and enhanced ATP concentration

Figenschau

Bertheussen

1999

Int J of Andrology

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We have developed a solution, fully described in this report, that can be used in a pretreatment procedure to promote liquefaction and to enhance motility during preparation of spermatozoa. It was applied to native ejaculates prior to swim-up and, in parallel investigations, motility and adenosine triphosphate concentration were compared in treated and untreated samples, which revealed that the solution significantly improved both parameters. The solution, named SpermSolute, is based on a proteinase (trypsin), which previously has been shown to stimulate the activity of a glycolytic key-enzyme. We speculate that our findings reflect intracellular enzyme activation and we suggest that our formula can be used in sperm preparation to prevent cell aggregates and to promote liquefaction, in addition to promotion of motility.

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“…There is considerable disagreement concerning the presence and function of a hyaluronidase in the acrosome (Chang, 1959;Kurzrok and B:irnberg, 1958;Mann, 1964;Moghissi et al, 1964;and Hartree and Srivastava, 1965 When such a physiological change results in an increased ability of the spermatozoa to fertilise the eggs of the female, they are said to be capacitated.…”

Section: ++ ++mentioning

confidence: 99%

“…Later, conflicting evidence was found that hyaluronic acid does not appear in cervical mucous which is thought to be a mucoid containing sialic acid (Moghissi et al, 1964).…”

Section: Substrates Ions and Pharmacologymentioning

confidence: 99%