Abstract:Originally identified as a member of the IAPs, survivin was discovered in 1997, and is one of the most powerful inhibiting factor of anti-apoptosis [1] . Studies suggest it has dual function of inhibiting apoptosis and maintaining cell division is located in chromosome 17q25, 14.5 kb in length, and is a protein of 16.3 KD containing 142 amino acid residues. Survivin specifically expresses in most tumor tissues while show rare exhibition in normal tissues, existing in fast proliferating but not terminally diff… Show more
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