Mechanism of resistance to streptothricin of a producing microorganism

Keeratipibul, Suwimon; Sugiyama, Masanori; Nomi, Ryosaku

doi:10.1007/bf00132225

Cited by 19 publications

(7 citation statements)

References 9 publications

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“…Some examples are also known of enzymic inactivation of the antibiotic by their producers, e.g. streptomycin (Sugiyama et al,198 I), streptothricin (Keeratibipul et al, 1983), viomycin and capreomycin (Skinner & Cundliffe, 1980) , 1985). On the other hand, a decrease in cell permeability to the antibiotic has been suggested to play an important role in self-protection in producers of streptomycin Nimi et al, 1981) and chloramphenicol (Malik & Vining, 1972).…”

Section: Discussionmentioning

confidence: 99%

Resistance to Oleandomycin in Streptomyces antibioticus, the Producer Organism

Fierro

Hardisson²,

Salas³

1987

Microbiology

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Resistance to oleandomycin in Streptomyces antibioticus, the producer organism, was studied. The organism was highly resistant in vivo to the antibiotic but sensitive to other macrolides and lincosamides. Protein synthesis in uivo by mycelium of S. antibioticus was more resistant to oleandomycin than that by mycelium of Streptomyces albus G, an oleandomycin-sensitive strain, and this resistance was dependent on the age of the culture, older mycelium of S. antibioticus being more resistant to oleandomycin than young mycelium.[ 3H]Oleandomycin was capable of binding to the same extent to the 50s subunits of the ribosomes of both organisms. Oleandomycin also inhibited in uitro protein synthesis by ribosomes obtained from an oleandomycin-production medium at the time when maximum levels of oleandomycin were being produced. A clear difference between the ability of the two organisms to incorporate exogenous oleandomycin was observed. Thus, while S. albus G took up oleandomycin, S. antibioticus showed a decreased permeability to the antibiotic, suggesting a role for cell permeability in self-resistance.

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Section: Discussionmentioning

confidence: 99%

Resistance to Oleandomycin in Streptomyces antibioticus, the Producer Organism

Fierro

Hardisson²,

Salas³

1987

Microbiology

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“…Both streptothricin and nourseothricin are inactivated by acetyltransferase activity [73,92] present in extracts of their producers (Streptomyces strain V-13-1 and Streptomyces noursei, respectively). Genes encoding such activity (sta from Streptomyces lavendulae [80], another streptothricin producer; nat, formerly ntr, from S. noursei [105]) confer high-level resistance in S. lividans and the product generated by purified streptothricin acetyltransferase (STAT) has been characterized as N b -acetylstreptothricin.…”

Section: Streptothricin and Nourseothricinmentioning

confidence: 99%

Avoidance of suicide in antibiotic-producing microbes

Cundliffe

Demain

2010

J Ind Microbiol Biotechnol

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Many microbes synthesize potentially autotoxic antibiotics, mainly as secondary metabolites, against which they need to protect themselves. This is done in various ways, ranging from target-based strategies (i.e. modification of normal drug receptors or de novo synthesis of the latter in drug-resistant form) to the adoption of metabolic shielding and/or efflux strategies that prevent drug-target interactions. These self-defence mechanisms have been studied most intensively in antibiotic-producing prokaryotes, of which the most prolific are the actinomycetes. Only a few documented examples pertain to lower eukaryotes while higher organisms have hardly been addressed in this context. Thus, many plant alkaloids, variously described as herbivore repellents or nitrogen excretion devices, are truly antibiotics-even if toxic to humans. As just one example, bulbs of Narcissus spp. (including the King Alfred daffodil) accumulate narciclasine that binds to the larger subunit of the eukaryotic ribosome and inhibits peptide bond formation. However, ribosomes in the Amaryllidaceae have not been tested for possible resistance to narciclasine and other alkaloids. Clearly, the prevalence of suicide avoidance is likely to extend well beyond the remit of the present article.

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“…Since, the discovery of the streptothricin, six analogs have been reported, streptothricin A–F. The analogs differ from the parent molecule in the number of β-lysine residues (Keeratipibul et al, 1983 ; Tschäpe et al, 1984 ).…”

Section: Acquired Resistancementioning

confidence: 99%

Acquired Antibiotic Resistance Genes: An Overview

Hoek¹,

Mevius²,

Guerra³

et al. 2011

Front. Microbio.

569

372

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In this review an overview is given on antibiotic resistance (AR) mechanisms with special attentions to the AR genes described so far preceded by a short introduction on the discovery and mode of action of the different classes of antibiotics. As this review is only dealing with acquired resistance, attention is also paid to mobile genetic elements such as plasmids, transposons, and integrons, which are associated with AR genes, and involved in the dispersal of antimicrobial determinants between different bacteria.

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Mechanism of resistance to streptothricin of a producing microorganism

Cited by 19 publications

References 9 publications

Resistance to Oleandomycin in Streptomyces antibioticus, the Producer Organism

Resistance to Oleandomycin in Streptomyces antibioticus, the Producer Organism

Avoidance of suicide in antibiotic-producing microbes

Acquired Antibiotic Resistance Genes: An Overview

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