Mechanism of propagation of intestinal interdigestive myoelectric complex

Gm, Carlson; Bedi, B.S.; Cf, Code

doi:10.1152/ajplegacy.1972.222.4.1027

Cited by 174 publications

(55 citation statements)

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“…The dog model is fairly representative of nonruminants that have cyclic motor activity (Sarna, 1985). The interdigestive motor pattern is quite unique , and is classified into 4 phases (Szurszewski, 1969 ;Carlson et al ., 1972 ;Code and Marlett, 1975).…”

Section: Discussionmentioning

confidence: 99%

Pyloric Opening and Closure Evaluated by Means of Strain Gauge Force Transducers.

Toyota

1998

J. Smooth Muscle Res.

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Recently, gastrointestinal motility research and various studies to measure motility have been conducted. However , it is not easy to measure the pyloric sphincter motility, especially its open and closed motility . There are few reports on the opening and closed motility of the pyloric ring . In this study, I examined the pyloric motility with strain gauge force transducers (SGTs) . SGTs were implanted onto the antrum , pyloric ring and duode num of a dog. In order to clarify the relationship between the opening and closed motility of the pylorus and SGTs recordings, the pyloric ring was observed with a gastrofiberscope while measurements were taken using the SGTs in anesthetized dogs . In addition, the pyloric ring was extended mechanically with a balloon and measurement were taken using the SGTs. In conscious dogs, the natural gastropyloroduodenal motility was recorded .Then, cisapride, erythromycin, and Leu13-motilin were administered in the interdigestive state and the motility was recorded . The pyloric opening and closed motility could be monitored using SGTs. The pyloric ring opened when the pyloric motility recorded using the SGTs showed a negative deflection . In addition, in phase III, when intense contraction of the antrum was observed , relaxation and opening of the pyloric ring could be observed.Erythromycin and Leu13-motilin induced phase III-like motility and relaxation of the pyloric ring. However, in cisapride-induced motility , relaxation of the pyloric ring was not observed. The pyloric ring opening and closed motility can be monitored using SGTs and this method is effective for the evaluation of the pyloric function .

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Section: Discussionmentioning

confidence: 99%

Pyloric Opening and Closure Evaluated by Means of Strain Gauge Force Transducers.

Toyota

1998

J. Smooth Muscle Res.

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“…Szurszewski identified the interdigestive myoelectric complex in the small intestine of fasted dogs (1). Code and collaborators (2,10,15,16) extended these studies and divided the complex into four different phases: phase one is characterized by the relative absence of action potentials; during phase two there is persistent but irregular action potential activity; phase three, the activity front, is characterized by its sudden onset and end, and by the presence of large action potentials on every pacesetter potential (or slow wave) of that period; during phase four, incidence and intensity of action potentials decline rapidly and disappear completely. Simultaneous measurements in dogs of intraluminal pressure changes and electrical activity have established the motor correlates of the interdigestive myoelectric complex (10).…”

Section: Discussionmentioning

confidence: 99%

The Interdigestive Motor Complex of Normal Subjects and Patients with Bacterial Overgrowth of the Small Intestine

Vantrappen¹,

Janssens²,

Hellemans³

et al. 1977

J. Clin. Invest.

780

380

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“…Whether the mechanism is neural or hormonal is unknown. Initially, in a Thiry-Vella loop model, it was thought that activity fronts systematically migrated from the main bowel proximal to the loop, to the loop itself, and then back to the main bowel distal to the loop (Carlson, Bedi & Code, 1972). This sequence implied a tight, probably neural, regulatory mechanism.…”

Section: Discussionmentioning

confidence: 99%

Effects of intestinal secretagogues and distension on small bowel myoelectric activity in fasted and fed conscious dogs

Melo

Summers

Thompson

et al. 1981

The Journal of Physiology

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SUMMARY1. Defined jejunal segments were perfused with solutions of bile salts and of ricinoleic acid during fasting and after feeding in two groups of conscious dogs, one with the segment in continuity, and the other with a Thiry-Vella loop. Myoelectric activity was recorded from chronically implanted electrodes on the jejunal segment and also from the proximal and distal in situ bowel.2. The results in both groups were identical. During fasting, migrating complexes were present in the segment, but were replaced by intermittent spike activity during chenodeoxycholate without and with ricinoleic acid perfusion. After food, when migrating complexes were replaced by intermittent spike activity, none of the solutions produced any consistent effect.3. In fasted animals, low levels of distension (15 mmHg) interrupted the migrating complexes in the segment and induced intermittent spike activity which was similar to that seen with the secretagogues. The migrating complexes in the main bowel continued during distension. In fed animals, spike activity increased in the segment during distension at 25 mmHg and decreased in the main bowel. In both groups, distension of the segment to pressures between 37-5 and 50 mmHg abolished spike activity both in the distended segment and the main bowel in fasted and fed states, and, in fasted dogs, migrating complexes were also abolished.4. These results demonstrate that the inhibitory intestino-intestinal reflex is mediated through extrinsic nerves and does not require an intact myenteric plexus, whereas the altered myoelectric activity induced by secretagogues is a local effect and does not spread to adjacent bowel through either intrinsic or extrinsic neural pathways. It seems likely that the local motor effect of secretagogues is a result of net secretion, producing distension to pressures below the threshold required to activate the intestino-intestinal reflex.t Present address:

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Mechanism of propagation of intestinal interdigestive myoelectric complex

Cited by 174 publications

References 0 publications

Pyloric Opening and Closure Evaluated by Means of Strain Gauge Force Transducers.

Pyloric Opening and Closure Evaluated by Means of Strain Gauge Force Transducers.

The Interdigestive Motor Complex of Normal Subjects and Patients with Bacterial Overgrowth of the Small Intestine

Effects of intestinal secretagogues and distension on small bowel myoelectric activity in fasted and fed conscious dogs

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