2000
DOI: 10.1007/bf02759618
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Mechanism of oligonucleotide hybridization with the 3′-terminal region of the yeast tRNAPhe

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Cited by 9 publications
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“…The time of complexes formation is comparable with the time of RNA cleavage under the action of the most efficient oligonucleotide conjugates [57]. At the same time, the strengths of binding of an oligonucleotide conjugate with an RNA target and its hydrolysis products are virtually the same, which leads to the inhibition of artificial nucleases by the hydrolysis products and, as a consequence, the catalytic mode of the hydrolysis cannot take place.…”
Section: Design and Synthesis Of Oligonucleotide Conjugates With Rnasmentioning
confidence: 98%
“…The time of complexes formation is comparable with the time of RNA cleavage under the action of the most efficient oligonucleotide conjugates [57]. At the same time, the strengths of binding of an oligonucleotide conjugate with an RNA target and its hydrolysis products are virtually the same, which leads to the inhibition of artificial nucleases by the hydrolysis products and, as a consequence, the catalytic mode of the hydrolysis cannot take place.…”
Section: Design and Synthesis Of Oligonucleotide Conjugates With Rnasmentioning
confidence: 98%