1973
DOI: 10.1677/joe.0.0580525
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MECHANISM OF OESTRADIOL ACTION ON THE RAT UTERUS: INDEPENDENCE OF CYCLIC AMP, PROSTAGLANDIN E2 AND Β-Adrenergic MEDIATION

Abstract: The hypothesis that cyclic AMP plays an essential role in mediating the biological action of oestradiol on the uterus, was tested by determining the tissue concentration of the cyclic nucleotide after incubation of uteri of immature rats with oestradiol or after injection of this steroid into immature or ovariectomized rats. The effect of known stimulants of uterine adenyl cyclase, namely \g=b\-adrenergicdrugs and prostaglandin E2 (PGE2), on the level of cyclic AMP in the uterus was also examined both in vitro… Show more

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Cited by 34 publications
(10 citation statements)
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References 18 publications
(30 reference statements)
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“…Notably, not all the physiological and biochemical changes associated with estrogen treatment are necessary for the uterotrophic effect. For example, while cAMP is elevated after estrogen administration (Szego & Davis 1967), uterine growth is independent of cAMP (Zor et al 1973). This is also true for ornithine decarboxylation and prostaglandins.…”
Section: Introductionmentioning
confidence: 94%
“…Notably, not all the physiological and biochemical changes associated with estrogen treatment are necessary for the uterotrophic effect. For example, while cAMP is elevated after estrogen administration (Szego & Davis 1967), uterine growth is independent of cAMP (Zor et al 1973). This is also true for ornithine decarboxylation and prostaglandins.…”
Section: Introductionmentioning
confidence: 94%
“…A role for a cyclic AMPdependent protein kinase in the regulation of orinthine decarboxylase activity has also been suggested by Byus and Russell [13]. However, estradiol given in vivo has been shown to increase ornithine decarboxylase activity in the rat uterus without changing the concentration of cyclic AMP [ 14]. Furthermore, the addition of serum or insulin to cell cultures is able to stimulate ornithine decarboxylase, but it decreases the level of cyclic AMP [ 12].…”
Section: Resultsmentioning
confidence: 88%
“…An increase in cytochemically demonstrable adenylate cyclase activity occurs in the cervicovaginal epithelium of mice in-iected with estradiol neonatally (1 5, 25). Although some controverse exists, it seems that elevation of cyclic AMP or stimulation of adenylate cyclase is not essential for the estradiol action in adult rodents (2, 13,18,23). In contrast to the usual proliferative effect of estradiol in the genital epithelium, this hormone inhibits the mitotic rate in the untransformed pseudostratified columnar epithelium in the cervicovaginal anlage of neonatal mice (6).…”
Section: Discussionmentioning
confidence: 99%