Mechanism of Nitrone Formation by a Flavin-Dependent Monooxygenase
Sydney B. Johnson,
Hao Li,
Hannah Valentino
et al.
Abstract:OxaD is a flavin-dependent monooxygenase (FMO) responsible for catalyzing the oxidation of an indole nitrogen atom, resulting in the formation of a nitrone. Nitrones serve as versatile intermediates in complex syntheses, including challenging reactions like cycloadditions. Traditional organic synthesis methods often yield limited results and involve environmentally harmful chemicals. Therefore, the enzymatic synthesis of nitrone-containing compounds holds promise for more sustainable industrial processes. In t… Show more
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