Mechanism of neutrophil dysfunction: Neutrophil serine proteases cleave and inactivate the C5a receptor

Berg, Carmen W. van den; Tambourgi, Denise V.; Clark, Helen; Hoong, J.; Spiller, O. Brad; McGreal, Eamon Patrick

doi:10.1016/j.molimm.2013.05.046

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2015

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“…C5aR (CD88) expression in renal biopsy specimens was predominantly tubular, was reduced in active vasculitis and absent on infiltrating glomerular neutrophils, raising questions about the importance of this receptor in AAV [51]. However, given that C5aR on neutrophils is internalized upon activation, and cleaved by neutrophil serine proteases from the surface of other cell types, this is not necessarily inconsistent with a role for C5aR in AAV [52]. Taken together these observations support a role for the alternative pathway of complement in human AAV, consistent with the murine data.…”

Section: Complementmentioning

confidence: 99%