Mechanism of neocryptotanshinone in protecting against cerebral ischemic injury: By suppressing M1 polarization of microglial cells and promoting cerebral angiogenesis

Zhai, Liping; Pei, Hongyan; Shen, Heping; Guan, Qing; Sheng, Jian

doi:10.1016/j.intimp.2023.109815

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…We established a UHPLC-QTOF-MS/MS analysis method, and identified main plant metabolites of seaweed, mainly alkaloid, terpenoids and coumarins, and also rich in vitamins and amino acids. LPS-induced microglial activation can lead to an inflammatory response and applied in cellular models ( Shen et al, 2022 ; Zhai et al, 2023 ). Therefore, in this study, LPS (lipopolysaccharide) was used to stimulate BV2 microglia to establish an in vitro neuronal inflammation model, and to verify the anti-neuroinflammatory effect of Sargassum pallidum and its three plant metabolites.…”

Section: Discussionmentioning

confidence: 99%

Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

Su,

Li,

Lai

et al. 2024

Front. Pharmacol.

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Immune inflammation is one of the main factors in the pathogenesis of depression. It is an effective and active way to find more safe and effective anti-inflammatory depressant drugs from plant drugs. The purpose of this study is to explore the potential of marine plant Sargassum pallidum (Turn).C.Ag. (Haihaozi, HHZ) in the prevention and treatment of depression and to explain the related mechanism. Phytochemical analysis showed that alkaloids, terpenes, and organic acids are the main constituents. In vitro and in vivo activity studies showed the anti-neuroinflammatory and antidepressant effect of Sargassum pallidum, furthermore, confirmed that 7-Hydroxycoumarin, Scoparone, and Kaurenoic Acid are important plant metabolites in Sargasum pallidum for anti-neuroinflammation. Mechanism exploration showed that inhibition of ERK1/2/p38 inflammatory signaling pathway contributing to the antidepressant effect of Sargassum pallidum in reducing intestinal inflammatory levels. This study confirmed the value of Sargassum pallidum and its rich plant metabolites in anti-inflammatory depression, providing a new choice for the follow-up research and development of antidepressant drugs.

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Section: Discussionmentioning

confidence: 99%

Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

Su,

Li,

Lai

et al. 2024

Front. Pharmacol.

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“…Several factors have been demonstrated to contribute to the enlargement of infarct volumes in stroke mice, such as the joint action of a variety of immune cells and inflammatory mediators, microglial activation, and dysfunction of oxidative stress and apoptosis. 81,82 Although ANP plays a crucial role in stroke, its action may not counteract that of other immune factors. Therefore, simply supplementing ANP may have a limited effect on the infarct area in PH mice with small brain infarctions.…”

Section: Discussionmentioning

confidence: 99%

Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal γδ T-cell migration into the brain and lung

Xie

Zhang

Han

et al. 2023

J Cereb Blood Flow Metab

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Social isolation (ISO) is associated with an increased risk and poor outcomes of ischemic stroke. However, the roles and mechanisms of ISO in stroke-associated pneumonia (SAP) remain unclear. Adult male mice were single- or pair-housed with an ovariectomized female mouse and then subjected to transient middle cerebral artery occlusion. Isolated mice were treated with the natriuretic peptide receptor A antagonist A71915 or anti-gamma-delta (γδ) TCR monoclonal antibody, whereas pair-housed mice were treated with recombinant human atrial natriuretic peptide (rhANP). Subdiaphragmatic vagotomy (SDV) was performed 14 days before single- or pair-housed conditions. We found that ISO significantly worsened brain and lung injuries relative to pair housing, which was partially mediated by elevated interleukin (IL)-17A levels and the migration of small intestine-derived inflammatory γδ T-cells into the brain and lung. However, rhANP treatment or SDV could ameliorate ISO-exacerbated post-stroke brain and lung damage by reducing IL-17A levels and inhibiting the migration of inflammatory γδ T-cells into the brain and lung. Our results suggest that rhANP mitigated ISO-induced exacerbation of SAP and ischemic cerebral injury by inhibiting small intestine-derived γδ T-cell migration into the lung and brain, which could be mediated by the subdiaphragmatic vagus nerve.

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Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha

Ma,

Shao,

Cheng

et al. 2023

Biomedicine & Pharmacotherapy

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Mechanism of neocryptotanshinone in protecting against cerebral ischemic injury: By suppressing M1 polarization of microglial cells and promoting cerebral angiogenesis

Cited by 5 publications

References 24 publications

Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal γδ T-cell migration into the brain and lung

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha

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