Mechanism of long non-coding RNA MALAT1 in lipopolysaccharide-induced acute kidney injury is mediated by the miR-146a/NF-κB signaling pathway

Ding, Ying; Guo, Feng; Zhu, Tao; Li, Jun; Gu, Danyan; Jiang, Weiliang; Lu, Y X; Zhou, Daoyang

doi:10.3892/ijmm.2017.3232

Cited by 52 publications

(65 citation statements)

References 37 publications

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“…[ 29,30 ] One research represented that lncRNA MALAT1 knockdown could mollify LPS‐engendered AKI via the mediation of miR‐146a. [ 31 ] Other research showed that NEAT1 repression could allay sepsis‐evoked AKI via targeting miR‐204. [ 32 ] MiR‐106b‐5p is a mature form of miR‐106b, which is encoded by the miR‐106b‐25 cluster in the long arm 21 regions of human chromosome 7 (7q21).…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA HOXA‐AS2 mediates microRNA‐106b‐5p to repress sepsis‐engendered acute kidney injury

Wu¹,

Wang

2020

J Biochem & Molecular Tox

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HOXA cluster antisense RNA 2 (HOXA‐AS2) is a long noncoding RNA associated with the development of numerous cancers. But, whether HOXA‐AS2 exhibits a certain function in sepsis‐engendered acute kidney injury (AKI) remains uninvestigated. We strived to unveil the role of HOXA‐AS2 in sepsis‐engendered AKI. The expression of HOXA‐AS2 in sepsis patients, animal models and lipopolysaccharide (LPS)‐impaired HK‐2 cells was primarily assessed via a real‐time quantitative polymerase chain reaction. The effects of HOXA‐AS2 on cell survival of HK‐2 cells under LPS irritation were evaluated after overexpression of HOXA‐AS2. The correlation between HOXA‐AS2 and microRNA (miR)‐106b‐5p was forecasted via bioinformatics software and verified by using a luciferase report system. Subsequently, the functions of miR‐106b‐5p in LPS‐damaged HK‐2 cells were reassessed. Western blot was used for the determination of Wnt/β‐catenin and nuclear factor‐κB (NF‐κB) pathways. HOXA‐AS2 expression was decreased in sepsis patients, animal operation group and LPS‐irritated HK‐2 cells. Overexpressed HOXA‐AS2 mollified LPS‐triggered impairment in HK‐2 cells. In addition, a negative mediatory relation between HOXA‐AS2 and miR‐106b‐5p was predicated. Synchronously, overexpressed miR‐106b‐5p counteracted the protection of HOXA‐AS2 in LPS‐damaged HK‐2 cells. Ultimately, Wnt/β‐catenin and NF‐κB pathways were hindered by HOXA‐AS2 via targeting miR‐106b‐5p. HOXA‐AS2 exhibited protection in sepsis‐engendered AKI via targeting miR‐106b‐5p and hindering the Wnt/β‐catenin and NF‐κB pathways.

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA HOXA‐AS2 mediates microRNA‐106b‐5p to repress sepsis‐engendered acute kidney injury

Wu¹,

Wang

2020

J Biochem & Molecular Tox

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“…Moreover, upregulation of NEAT1 negatively regulates miR‐204 and activates NF‐κB pathway, thereby serves as an important diagnostic marker and therapeutic target in sepsis‐induced AKI patients (Chen et al, ). In addition, MALAT1 and Maternally expressed gene 3 (MEG3) promotes LPS‐induced AKI by modulating miR‐146a/NF‐κB axis and miR‐21/PDCD4 pathways, respectively (Ding et al, ; R. Yang et al, ). Arid2‐IR is a newly identified proinflammatory lncRNA in kidney disease.…”

Section: Role Of Lncrnas In Akimentioning

confidence: 99%

Noncoding RNAs in acute kidney injury

Ren

Zhu

et al. 2018

Journal Cellular Physiology

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Acute kidney injury (AKI), caused by various stimuli including ischemia reperfusion, nephrotoxic insult, and sepsis, is characterized by abrupt decline of kidney function. Till now, the molecular mechanisms for AKI have not been fully explored and the effective therapies are still lacking. Noncoding RNAs (ncRNAs), a group of biomolecules function at RNA level, are involved in a wide range of physiopathological processes including AKI. MicroRNAs (miRNAs) are the most extensively studied ncRNAs in AKI. Evidence indicated that miRNAs are altered significantly in various types of AKI. Gain-and-loss-of-function studies demonstrated that miRNAs, such as miR-24, miR-126, miR-494, and miR-687, may bind to the 3'-untranslated region of their target genes to regulate inflammation, programmed cell death, and cell cycle in the injury and repair stages of AKI, indicating their therapeutic potential in AKI. In contrast, functions of long noncoding RNAs and circular RNAs in AKI are hot topics but still largely unknown. Additionally, ncRNAs packaged in exosome can be detected in circulation and urine, they may serve as specific biomarkers for AKI. This review summarized the alteration and functional role of ncRNAs and their therapeutic potential in AKI.

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“…It is suggested that after binding to a specific protein, MALAT1 can shuttle between the cytoplasm and the nucleus to alter the intracellular localization of the protein. MiR-129-5p Growth and metastasis of triple-negative breast cell↑ Zuo, Li, Zhou, Ma, and Fu (2017) MiR-142-3p and miR-129-5p HMGB1 Growth of osteosarcoma cell↑ MiR-129-5p HMGB1 Proliferation of colon cancer↑ Jie and Zhao (2017) MiR-133 Srf Differentiation of myocyte↑ Han, Yang Cao, and Liang (2015) MiR-140 Slug and ADAM10 Growth and invasion of uveal melanoma cell↑ MiR-140 NFYA Blood-tumor barrier permeability↓ Ma et al (2016) MiR-143-3p ZEB1 Growth and invasion of hepatocellular carcinoma cell↑ MiR-144-3p ROCK1 and ROCK2 Metastasis and proliferation of osteosarcoma cell↑ MiR-145 TGFBR2 and SMAD3 TGF-β1-induced EMT↑ Xiang, Zhang, Tang, and Li (2017) MiR-145 Bnip3 Cardioprotective effects↑ Zhao et al (2016) MiR-146b-5p TRAF6 Growth and metastasis of hepatocellular carcinoma cell↑ MiR-146a LPS-induced acute kidney injury↑ Ding et al (2018) MiR-155 FBXW7 Cell viability in glioma cell↓ Cao et al (2016) MiR-183 ITGB1 Cell growth in melanoma cell↑ Sun, Qin et al (2016) MiR-195 EGFR Growth and metastasis of hepatocellular carcinoma cell↑ MiR-200c ZEB1 and ZEB2 Endometriosis↑…”

Section: Malat1 Assists Protein Localizationmentioning

confidence: 99%

Functions and regulatory mechanisms of metastasis‐associated lung adenocarcinoma transcript 1

Chen

Huang

et al. 2018

Journal Cellular Physiology

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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA whose transcript is around 8 kb in length. As an important stress response molecule, MALAT1 can be expressed differently under stress conditions, such as hypoxia, high glucose, hydrogen peroxide, ultraviolet irradiation, infection, and chemical stimulation. MALAT1 is involved in regulating multiple cell behaviors, such as proliferation, apoptosis, differentiation, migration, epithelial-mesenchymal transition, autophagy, and morphological maintenance. Extensive evidence show that MALAT1 plays critical roles in the physiopathological process of embryo implantation, angiogenesis, tissue inflammation, tumor progression, liver fibrosis, cardiovascular remodeling, and diabetes progression by regulating gene transcription, forming RNA-protein complexes with proteins as a structural component, regulating protein activity, assisting protein localization, mediating epigenetic changes, or by acting as a competing endogenous RNA. Furthermore, MALAT1 can affect the sensitivity of chemotherapy and radiotherapy; therefore, it could be used as a potential drug target for chemotherapy and radiotherapy sensitization. The levels of MALAT1 are reported to be overexpressed in most tumor tissues or sera, and the expression levels of MALAT1 often affect the tumor size, stage, lymph node metastasis, and distant invasion. Therefore, MALAT1 can be used as a biomarker for early diagnosis, severity assessment, or prognostic assessment. This review outlines the current understanding of the biological role and function of MALAT1. In the meantime, we have summarized the mechanisms involved in the reulation of MALAT1 expression and the mechanisms by which MALAT1 regulates the physiological and pathological processes.

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Mechanism of long non-coding RNA MALAT1 in lipopolysaccharide-induced acute kidney injury is mediated by the miR-146a/NF-κB signaling pathway

Cited by 52 publications

References 37 publications

Long noncoding RNA HOXA‐AS2 mediates microRNA‐106b‐5p to repress sepsis‐engendered acute kidney injury

Long noncoding RNA HOXA‐AS2 mediates microRNA‐106b‐5p to repress sepsis‐engendered acute kidney injury

Noncoding RNAs in acute kidney injury

Functions and regulatory mechanisms of metastasis‐associated lung adenocarcinoma transcript 1

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