Mechanism of leptin removal from the circulation by the kidney

Cumin, Frédéric; Baum, H P; Levens, Nigel

doi:10.1677/joe.0.1550577

Cited by 106 publications

(110 citation statements)

References 20 publications

(16 reference statements)

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“…These short-term variations were likely to reflect changes in secretion rather than clearance. Leptin is rapidly cleared from the circulation by renal extraction, which is a high capacity, non-saturable process (Cumin et al 1997, Zeng et al 1997. Like Blache et al (2000), we found no evidence for a diurnal rhythm of plasma leptin in sheep occurring independently from the timing of meals, in either photoperiod.…”

Section: Discussioncontrasting

confidence: 60%

Daily patterns of plasma leptin in sheep: effects of photoperiod and food intake

Marié¹,

Findlay²,

Thomas³

et al. 2001

Journal of Endocrinology

147

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Circulating concentrations of leptin in sheep correlate with body fatness and are affected by level of food intake and photoperiod. The present objective was to elucidate the short-term dynamics of leptin secretion. Frequent blood samples were taken over 48 h from 12 Soay rams after 16 weeks in short-day photoperiod (SD, 16 h darkness:8 h light) with freely available food, and then after 16 weeks in long days (16 h light:8 h darkness) with food freely available (LD) or restricted to 90% maintenance (LDR) (n=6/ group). During the second 24 h of sampling, half were food deprived (n=6, SD and LD) and half had their meal times shifted (n=6, SD and LDR). A homologous RIA was developed, using antibodies raised in chicken against recombinant ovine leptin, to measure plasma concentrations. Simultaneous 24 h profiles of plasma insulin, glucose and non-esterified fatty acids (NEFA) were measured. Plasma leptin was higher in LD than SD, and in LD than LDR, associated with higher food intake, liveweight and body condition score (adiposity), but tended to be lower in LDR than SD, associated with lower food intake, liveweight and body condition score. There was no evidence for a circadian rhythm of plasma leptin, but clear evidence for post-prandial peaks of low amplitude (15-36%) 2-8 h after meals given at normal and shifted times. Complete food deprivation caused a dramatic fall in plasma leptin to basal levels within 24 h. There was a positive association of plasma leptin with plasma insulin, and negative association with NEFA, both between meals and during fasting. Thus, plasma leptin concentrations in sheep are sensitive to short-term changes in energy balance, as well as to long-term photoperiod-driven changes in food intake and adiposity.

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Section: Discussioncontrasting

confidence: 60%

Daily patterns of plasma leptin in sheep: effects of photoperiod and food intake

Marié¹,

Findlay²,

Thomas³

et al. 2001

Journal of Endocrinology

147

View full text Add to dashboard Cite

show abstract

“…Adipose tissue production, renal clearance, and hepatic metabolism are important determinants of the serum leptin level [44, 45, 46, 47]. As GH receptors are present and functional in all three tissues [48, 49, 50, 51, 52, 53], there is no definite indication as to the mechanism of GH downregulation of the leptin axis.…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone Treatment Downregulates Serum Leptin Levels in Children Independent of Changes in Body Mass Index

et al. 1999

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The changes in serum leptin levels during growth hormone (GH) treatment were studied in 27 children, 17 with GH deficiency (GHD), 10 with idiopathic short stature (ISS), and 9 with Prader-Willi syndrome (PWS). Within 1 month of GH treatment, serum leptin levels decreased by 40% in the GHD children (p < 0.01). There was no significant change in serum leptin level in the children with ISS. In children with PWS, the mean serum leptin level decreased by almost 60% after 3 months of treatment (p < 0.001). Thereafter, no further decline was observed in any of the 3 groups. Changes in body composition became evident first after the 3 months of treatment. In the GHD children, the BMI was unchanged while the mean body fat percentage was 2.7% lower after 1 year of GH treatment (p < 0.05). In the ISS children, neither BMI nor body fat percentage were significantly changed during treatment. The PWS children exhibited a significant decrease in BMI after 6 months of GH treatment without any further change during the remaining period of treatment. In this group, the mean body fat percentage decreased from 42 ± 2.4 to 28 ± 2.2% after treatment (p < 0.001). The finding that the fall in leptin occurs before changes in body composition become detectable suggests a direct effect of GH on leptin production, metabolism, or clearance.

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“…It was demonstrated that endogenous leptin is cleared from the circulation in the kidney by glomerular ®ltration, followed by metabolic degradation in the renal tubules of Zucker (faafa) 19 and Sprague ± Dawley rats. 20,21 In humans, circulating leptin concentrations are related to the degree of renal function, assessed by 1aplasma creatinine. 22 In contrast, it has been recently reported that intact leptin is increased in patients with end-stage renal disease, although increased production may account for the high concentrations of leptin.…”

Section: Introductionmentioning

confidence: 99%

An increase of circulating leptin in patients with liver cirrhosis

et al. 1998

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OBJECTIVE: Leptin, the ob gene product, is an anorexigenic peptide secreted from adipose tissue. However, the mechanism of leptin clearanceadegradation has not been well determined in humans. The present study was undertaken to examine a possible involvement of liver in determining circulating leptin concentrations in humans. SUBJECTS: In the present study 58 healthy control subjects and 68 patients with liver cirrhosis (LC) without any renal dysfunction were randomly included. METHOD: The serum immunoreactive leptin (IRL) concentrations relative to the body mass index (BMI) were determined. Serum IRL and estradiol (E 2 ) concentrations were assayed by radioimmunoassay (RIA). RESULTS: The correlations between the BMI and circulating IRL concentrations were all signi®cant in male healthy controls (M-C), male patients with LC (M-LC), female healthy controls (F-C) and female patients with LC (F-LC). Circulating IRL concentrations were signi®cantly higher than control in F-LC but not M-LC groups. The ratio of circulating IRL concentrations to the BMI was signi®cantly higher in the M-LC group than in the M-C group and also signi®cantly higher in the F-LC group than in the F-C group. The correlation between the IRLaBMI ratio and serum total bilirubin concentrations was signi®cant (r 0.417, P`0.05) in the M-LC group, but not in the F-LC group. There was no signi®cant correlation of the IRLaBMI ratio to serum E 2 or albumin concentrations in either M-LC or F-LC groups.CONCLUSION: The present data demonstrated that the rate of increase in circulating IRL concentrations with the BMI was higher in LC patients of both genders. Liver may play a role in determining circulating leptin levels.

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Mechanism of leptin removal from the circulation by the kidney

Cited by 106 publications

References 20 publications

Daily patterns of plasma leptin in sheep: effects of photoperiod and food intake

Daily patterns of plasma leptin in sheep: effects of photoperiod and food intake

Growth Hormone Treatment Downregulates Serum Leptin Levels in Children Independent of Changes in Body Mass Index

An increase of circulating leptin in patients with liver cirrhosis

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