Mechanism of ‘Invigorating Qi and Promoting Blood Circulation’ Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology

Xin, Gao-Jie; Zhao, Yuwei; Li, Lingmei; Jia, Fei-Fan; Han, Xiao; Li, Lei; Guo, Hao; Meng, Hongxu; Fu, Jianhua; Liu, Jianxun

doi:10.1007/s11655-021-2859-y

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…According to the results of previous studies, ginseng, a component of GEJ, can inhibit skeletal muscle atrophy, enhance muscle performance and improve blood circulation [22][23][24][25]. Another Chinese herb in the GEJ formula, lycium, can also improve muscle endurance [26].…”

Section: Discussionmentioning

confidence: 99%

The Benefits of Guilu Erxian Jiao for Patients With Osteoporosis: A Retrospective Study

Lai

Tseng

Yang

et al. 2021

Preprint

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Objective: The objective of this study was to evaluate whether the Chinese herbal medicine formula Guilu Erxian Jiao can improve the T-score in osteoporosis patients and even decrease the fracture rate.Design: This is a retrospective study.Subjects and Setting: Osteoporosis participants were selected from the Chang Gung Memorial Hospital (CGMH) database from 2000 to 2019.Interventions: The patients were administered Guilu Erxian Jiao pills.Outcome measures: We analyzed the change of T-score and the associated cumulative incidence of fracture.Results: Eighty-five patients administered GEJ met the inclusion criteria. After propensity score matching (1:5), 425 patients who were not administered GEJ were included in the control group. There were no significant differences about the baseline characteristics between the study and control groups. In the study group, GEJ improved the osteoporosis of the lumbar vertebrate and osteopenia of the hip joint but did not improve osteoporosis of the femoral neck. The cumulative rate of fracture between these two groups was not significantly different. Patients who took at least 600 GEJ pills over the treatment period had a decreased risk for fracture at fracture-prone sites.Conclusion:The use of Guilu Erxian Jiao may improve osteoporosis of the lumbar vertebrate and osteopenia of the hip joint. In addition, it may help decrease fractures of the lumbar spine. Administering at least 600 GEJ pills over the treatment period might result in a decreased risk for fracture at fracture-prone sites.

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Section: Discussionmentioning

confidence: 99%

The Benefits of Guilu Erxian Jiao for Patients With Osteoporosis: A Retrospective Study

Lai

Tseng

Yang

et al. 2021

Preprint

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“…The root of the ginseng plant is particularly prized for its medicinal properties, containing polysaccharides, saponins, volatile oil, trace elements, organic acid, proteins and other chemical compositions. Ginseng is known for its effectiveness in replenishing primordial Qi, tonifying the spleen and lung, generating body fluids, calming mind and enhancing intelligence ( Xin et al, 2021 ). Modern pharmacology research has revealed that ginseng exerts notable effects on the immune system, central nervous system, cardiovascular system, metabolism, infectious and neoplastic diseases ( Chen et al, 2008 ; Choi et al, 2015 ; Mancuso and Santangelo, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Global ginseng trade networks: structural characteristics and influencing factors

et al. 2023

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Background: Ginseng is a rare and highly valued Chinese materia medica with a rich trading history and has a wide range of application, including medicine, food, healthcare, and daily chemical production. However, the global trade of ginseng exhibits diverse features and uneven development across different countries and regions. Surprisingly, the intricate network relationship and the underlying characteristics and influencing factors of ginseng trade networks remain unexplored.Methods: This study analyzed ginseng trade data obtained from the UN-Comtrade database and used social network analysis to construct global ginseng trade networks. To elucidate the structural characteristics, we analyzed the indicators of the overall network structure and node attributes. Core-periphery analysis is used to examine the evolutionary patterns within the global ginseng trade networks. Furthermore, we apply the quadratic assignment procedure to investigate the impact and relevance of spatial proximity, cultural differences, economic indicators, population size, technological similarity, and institutional distance.Results: The findings reveal that the global ginseng trade networks exhibit typical small-world and scale-free properties, as well as a core-periphery structure. Several core countries, including China, South Korea, Germany, and the United States, exert significant control over both trade volume and trade partners. South Korea and China initially occupied central positions in the export market due to their resource endowments, their prominence has gradually diminished with the ascendancy of Germany and the United States. According to the core-periphery analysis, the ginseng trade has shown a gradual concentration within specific trade groups comprising core and semi-periphery countries, most of which are along the “Belt and Road” religion. We also found that geographic distance and GDP per capita exert negative effects on ginseng trade, while factors such as land adjacency, technology and economic gap, population size, and institution similarity play significant positive roles.Conclusion: The global ginseng trade has experienced increasing concentration and close linkage among a limited numbers of participants. It is crucial to pay close attention to the relationship between ginseng industry development and resource conservation. Strategies such as expanding trade channels, implementing trade substitution measures, and optimizing the quality and standards of ginseng products can effectively enhance trade security.

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“…However, the results obtained in experiments with RG, RS, and OCF cannot be mechanistically extrapolated on RG-RS because that is a different substance with a different chemical composition consisting of 17 active constituents from RG and 53 active constituents from RS [46], which can interact synergistically and antagonistically in the target cells of the organism on transcriptomic and proteomic regulation levels of the cellular metabolism.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics

Panossian¹,

Abdelfatah

Efferth

2022

Pharmaceuticals

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Background: This study aimed to assess the effect of a fixed combination of Red Ginseng and Red Sage (RG–RS) on the gene expression of neuronal cells to evaluate the potential impacts on cellular functions and predict its relevance in the treatment of stress and aging-related diseases and disorders. Methods: Gene expression profiling was conducted by transcriptome-wide mRNA microarray analyses of murine HT22 hippocampal cell culture after treatment with RG–RS preparation. Ingenuity pathway analysis (IPA) was performed with datasets of significantly upregulated or downregulated genes and the expected effects on the physiological and cellular function and the diseases were identified. Results: RG–RS deregulates 1028 genes associated with cancer and 139 with metastasis, suggesting a predicted decrease in tumorigenesis, the proliferation of tumor cells, tumor growth, metastasis, and an increase in apoptosis and autophagy by their effects on the various signaling and metabolic pathways, including the inhibition of Warburg’s aerobic glycolysis, estrogen-mediated S-phase entry signaling, osteoarthritis signaling, and the super-pathway of cholesterol biosynthesis. Conclusion: The results of this study provide evidence of the potential efficacy of the fixed combination of Red Ginseng (Panax ginseng C.A. Mey.) and Red Sage/Danshen (Salvia miltiorrhiza Bunge) in cancer. Further clinical and experimental studies are required to assess the efficacy and safety of RG–RS in preventing the progression of cancer, osteoarthritis, and other aging-related diseases.

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Mechanism of ‘Invigorating Qi and Promoting Blood Circulation’ Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology

Cited by 11 publications

References 15 publications

The Benefits of Guilu Erxian Jiao for Patients With Osteoporosis: A Retrospective Study

The Benefits of Guilu Erxian Jiao for Patients With Osteoporosis: A Retrospective Study

Global ginseng trade networks: structural characteristics and influencing factors

Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics

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