Mechanism of increased risk of insulin resistance in aging skeletal muscle

Shou, Jian; Chen, Peijie; Xiao, Wu

doi:10.1186/s13098-020-0523-x

Cited by 167 publications

(147 citation statements)

References 109 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…25,26 The aging mechanisms that lead to tissue dysfunctions are related to, lipid accumulation in cells, intracellular dysfunctions in mitochondrial activities, proinflammatory states, high oxygen reactive species and free radicals causing oxidative stress, dysfunction of insulin sensitivity regulatory enzymes and autophagy. 27 Intramyocellular involvement and sarcopenia is also associated with all the above mentioned mechanisms and exacerbates insulin resistance with its consequences. Therefore, during skeletal muscle aging there will be an increase in insulin resistance that leads to T2DM.…”

Section: Discussionmentioning

confidence: 99%

<p>Sarcopenia Coexisting with High Adiposity Exacerbates Insulin Resistance and Dyslipidemia in Saudi Adult Men</p>

Habib¹,

Alkahtani²,

Alhussain³

et al. 2020

DMSO

View full text Add to dashboard Cite

The associations between sarcopenia, adiposity indices and metabolic dysregulation still remain controversial. We aimed to assess and compare insulin resistance and metabolic profile in sarcopenic and non-sarcopenic obese Saudi adult men. Methods: This cross sectional study was conducted at the College of Sports Sciences, King Saud University, Riyadh. We recruited 312 Saudi adult male individuals and 288 were finally selected for the study. Body composition analysis and hand grip strength (HGS) were estimated by bioimpedance analysis (BIA) and dynamometer in all subjects, respectively. Fasting blood samples were collected for glucose (FBG), basal insulin (BI) and lipid profile. The subjects were divided into three groups based on the body composition parameters, appendicular lean mass (ALM) and body fat percentage (BF%), into non-obese (NonOb) [Normal ALM+<25 BF%], obese without sarcopenia (ObNonS) [Normal ALM+>25 BF%] and obese with sarcopenia (ObS) [Low ALM+>25 BF%]. Results: Obese subjects had significantly higher BI, HOMA-IR and HOMA-β compared to non-obese. Moreover, comparison between two obese groups revealed that both BI and HOMA-IR levels were higher in ObS subjects compared to ObNonS individuals revealing that sarcopenia exacerbates the insulin resistance profile. There was a significant trend of higher resistance and lower sensitivity from non-obese to obesity with sarcopenia. Total cholesterol (TC) and triglycerides (TG) were significantly higher and high density lipoprotein cholesterol (HDL-C) was significantly lower in sarcopenic obese subjects compared to non-sarcopenic obese individuals. The worsening effects were more significant at cutoff point of 7.46 on insulin indices and lipid profile showing that sarcopenia associated with obesity exacerbates the dyslipidemia. Conclusion: Our study shows that obesity associated with sarcopenia exhibits significantly greater insulin resistance and dyslipidemia than sarcopenia or obesity per se. Therefore, sarcopenic obesity might be an independent risk factor for metabolic disease progression.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Sarcopenia Coexisting with High Adiposity Exacerbates Insulin Resistance and Dyslipidemia in Saudi Adult Men</p>

Habib¹,

Alkahtani²,

Alhussain³

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…Previous studies have associated age-related processes, such as increase in adiposity, skeletal muscle mitochondrial dysfunction and chronic low-grade inflammation, with insulin resistance [ 117 , 118 , 119 ]. Nutritional interventions may aid in preventing or delaying prediabetes by optimizing the biomarkers correlated with these deleterious processes.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Strategies in Prediabetes: A Scoping Review of Recent Evidence

Yau¹,

Thor²,

Ramadas³

2020

Nutrients

View full text Add to dashboard Cite

Nutritional therapy has been conventionally recommended for people with prediabetes as a method to delay or halt progression to type 2 diabetes. However, recommended nutritional strategies evolve over time. Hence, we performed a scoping review on recently reported nutritional interventions for individuals with prediabetes. Ovid MEDLINE, PubMed, Embase, Scopus, CINAHL and PsycINFO databases were searched to identify relevant research articles published within the past 10 years. Ninety-five articles involving a total of 11,211 participants were included in this review. Nutritional strategies were broadly classified into four groups: low calorie diet, low glycemic index diet, specific foods, and a combination of diet and exercise. The most frequently assessed outcomes were plasma glucose, serum insulin, serum lipid profile, body mass index and body weight. More than 50% of reported interventions resulted in significant improvements in these parameters. Nutritional interventions have demonstrated feasibility and practicality as an effective option for prediabetes management. However, the intervention variability demonstrates the challenges of a ‘one-size-fits-all’ approach. Investigations in genetically diverse populations and objective assessment of progression rate to diabetes are necessary to better comprehend the impact of these nutritional strategies in prediabetes.

show abstract

“…Such investigations may measure postprandial glucose and insulin concentrations following an oral glucose tolerance test, or the gold-standard hyperinsulinaemic-euglycaemic clamp technique [89]. The findings from these trials may be of particular importance for older persons, given that glycaemic control may be impaired in this population due to losses in skeletal muscle mass and function that predispose individuals to reduced skeletal muscle insulin sensitivity [34,90].…”

Section: Glycaemic Controlmentioning

confidence: 99%

The Potential Role of Fish-Derived Protein Hydrolysates on Metabolic Health, Skeletal Muscle Mass and Function in Ageing

Lees

Carson

2020

Nutrients

View full text Add to dashboard Cite

Fish protein represents one of the most widely consumed dietary protein sources by humans. The processing of material from the fishing industry generates substantial unexploited waste products, many of which possess high biological value. Protein hydrolysates, such as fish protein hydrolysates (FPH), containing predominantly di- and tripeptides, are more readily absorbed than free amino acids and intact protein. Furthermore, in animal models, FPH have been shown to possess numerous beneficial properties for cardiovascular, neurological, intestinal, renal, and immune health. Ageing is associated with the loss of skeletal muscle mass and function, as well as increased oxidative stress, compromised vascularisation, neurological derangements, and immunosenescence. Thus, there appears to be a potential application for FPH in older persons as a high-quality protein source that may also confer additional health benefits. Despite this, there remains a dearth of information concerning the impact of FPH on health outcomes in humans. The limited evidence from human interventional trials suggests that FPH may hold promise for supporting optimal body composition and maintaining gut integrity. FPH also provide a high-quality source of dietary protein without negatively impacting on subjective appetite perceptions or regulatory hormones. Further studies are needed to assess the impact and utility of FPH on skeletal muscle health in older persons, ideally comparing FPH to ‘established’ protein sources or a non-bioactive, nitrogen-matched control. In particular, the effects of acute and chronic FPH consumption on post-exercise aminoacidaemia, skeletal muscle protein synthesis, and intramyocellular anabolic signalling in older adults are worthy of investigation. FPH may represent beneficial and sustainable alternative sources of high-quality protein to support skeletal muscle health and anabolism in ageing, without compromising appetite and subsequent energy intake.

show abstract

Mechanism of increased risk of insulin resistance in aging skeletal muscle

Cited by 167 publications

References 109 publications

<p>Sarcopenia Coexisting with High Adiposity Exacerbates Insulin Resistance and Dyslipidemia in Saudi Adult Men</p>

<p>Sarcopenia Coexisting with High Adiposity Exacerbates Insulin Resistance and Dyslipidemia in Saudi Adult Men</p>

Nutritional Strategies in Prediabetes: A Scoping Review of Recent Evidence

The Potential Role of Fish-Derived Protein Hydrolysates on Metabolic Health, Skeletal Muscle Mass and Function in Ageing

Contact Info

Product

Resources

About