Mechanism of Huiru decoction on hyperprolactinemia in rats

Myricetin reduces neutrophil extracellular trap release in a rat model of rheumatoid arthritis, which is associated with a decrease in disease severity

“…We aimed to enrich the scientific understanding of the intervention of RA with Pterocaryarhoifolia total flavonoids by studying the mechanisms of MC intervention in RA, providing experimental and theoretical foundations for the utilization and development of total flavonoids for the treatment of RA. 11,18 This will better serve the clinical setting and benefit patients by offering solutions for preventing and treating RA-related conditions (Figure 6). Furthermore, we will continue our research and exploration in subsequent experiments to investigate whether MC achieves its intervention effects in RA through other pathways and whether there are any differences in expression in neutrophils extracted from human blood samples.…”

“…16 Myricetin has been shown to significantly reduce inflammation in RA through different mechanisms, including modulation of IL-21 and histone K activity and targeting AIM2 to inhibit fibroblast-like synoviocyte-mediated rheumatoid synovial inflammation and joint destruction. [17][18][19] To further refine the mechanism of action of MC intervention in RA, we conducted a network pharmacology analysis based on existing databases to identify common target proteins between MC and RA. We focused on the involvement of PADI4 and MPO proteins, both of which are closely related to NET formation.…”