Mechanism of Hormonal Action

Snart, R.S.

doi:10.1159/000178183

Cited by 10 publications

(2 citation statements)

References 33 publications

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“…The low dose of vasopressin (1 mu./ml.) has previously been associated with direct permeability effects of vasopressin and maximum stimulation of Na+ transport (Snart, 1970) whereas the higher doses of vasopressin (100 mu./ml.) have been associated with maximum stimulation of adenylate cyclase activity (Besley & Snart, 1973) dephosphorylation of membrane proteins and stimulation of water transport (Ferguson & Twite, 1974).…”

Section: Introductionmentioning

confidence: 96%

Effect of steroid depletion on the response of toad bladder to vasopressin.

Debnam¹,

Hewitt²,

Snart³

1975

The Journal of Physiology

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1. We have investigated the water transport and short‐circuit current (s.c.c.) response to vasopressin (1 mu./ml. and 100 mu./ml.) in isolated toad urinary bladders (Bufo marinus) following overnight incubation in the presence or absence of steroid‐containing Ringer solution. 2. The water transport response to the lower dose of vasopressin (1 mu./ml.) was considerably reduced in 'steroid depleted' conditions, wheras the response to the higher dose of vasopressin (100 mu./ml.) was not similarly affected. 3. Aldosterone 3. Aldosterone 3. Aldosterone (10(‐7)M) potentiated the water transport response to the lower dose of vasopressin (1 mu./ml.) but had no effect on the response to the higher dose (100 mu./ml.). 4. There was no effect of 'steroid depletion' or aldosterone treatment on the vasopressin s.c.c. response when measured as a percentage increase above basal levels. 5. In 'steroid depleted' conditions vasopressin (1 mu./ml.) maximally stimulated Na+ transport (s.c.c.) but a higher dose of vasopressin (100 mu./ml.) was required for maximum water transport. 6. We have failed to obtain any potentiation effect of corticosterone (10(‐7)M) on the water transport or s.c.c. response to vasopressin (1 mu./ml.).

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Section: Introductionmentioning

confidence: 96%

Effect of steroid depletion on the response of toad bladder to vasopressin.

Debnam¹,

Hewitt²,

Snart³

1975

The Journal of Physiology

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“…In studies of the mechanism of aldosterone action in the toad bladder (Leaf, 1965;Edelman, 1966) considerable attention has been given to the problem of which process normally limits sodium transport. Sharp & Leaf (1966) and Snart (1970) favour the idea that sodium transport across the bladder is normally limited by the permeability of the mucosal surface and that the effect of aldosterone is to increase this permeability. Edelman & Fanestil (1970) on the other hand support the view that the ion pump is normally rate limiting and that aldosterone acts to increase the activity of this enzyme pump, independent of any effect on mucosal permeability.…”

Section: Introductionmentioning

confidence: 99%

Aldosterone effects on renal metabolism.

Snart¹,

Taylor²

1978

The Journal of Physiology

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SUMMARY1. Manometric studies of the sodium dependent oxygen consumption in rat kidney slices have failed to reveal any significant effect of aldosterone treatment, adrenalectomy or sodium diet on sodium metabolism.2. However, ammonia release from kidney slices was significantly reduced following adrenalectomy and this decrease was influenced by aldosterone treatment.3. The dose-response characteristic obtained for this aldosterone-stimulated ammonia release has been determined.4. The effect of a high Na+ diet on the ammonia release has been studied. An initial decrease after 2 days may be associated with decreased endogenous aldosterone secretion. However, aldosterone (2.5 /ag/100 g body weight) injections into these high Na+ treated animals fails to restore the normal ammonia release.

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Effect of diethylnitrosamine on the respiratory and enzymic response of rat liver to corticosterone

Dalton

Snart

1971

Biochemical Pharmacology

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Mechanism of Hormonal Action

Cited by 10 publications

References 33 publications

Effect of steroid depletion on the response of toad bladder to vasopressin.

Effect of steroid depletion on the response of toad bladder to vasopressin.

Aldosterone effects on renal metabolism.

Effect of diethylnitrosamine on the respiratory and enzymic response of rat liver to corticosterone

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