Mechanism of hepatic targeting via oral administration of DSPE&amp;ndash;PEG&amp;ndash;cholic acid-modified nanoliposomes

Liu, Ying; Zhu, Chun

doi:10.2147/ijn.s125047

Cited by 18 publications

(6 citation statements)

References 37 publications

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“…The integrity of GCA-NPs after penetration through Caco-2 cell monolayers was analyzed using FRET technology. DiO and DiI were chosen as FRET pairs and loaded into GCA-NPs (DiO/DiI@GCA-NPs) [ 43 , 52 ]; the concentration of the two dyes was 100 μg/mL. The FRET signal was assayed using a fluorospectrophotometer at an excitation wavelength of 480 nm and detection range of 500–600 nm.…”

Section: Methodsmentioning

confidence: 99%

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs

et al. 2022

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Background Oral chemotherapy is preferred for patients with cancer owing to its multiple advantages, including convenience, better patient compliance, and improved safety. Nevertheless, various physical barriers exist in this route that hamper the development of oral chemotherapeutic formulations, including destruction of drugs in the gastrointestinal tract (GIT), low permeability in enterocytes, and short residence time in the intestine. To overcome these limitations, it is necessary to design an efficient oral drug delivery system with high efficacy and improved safety. Results Herein, we designed novel glycocholic acid (GCA)-functionalized double layer nanoparticles (GCA-NPs), which can act via an endogenous pathway and in a temporally controlled manner in the intestine, to enhance the oral bioavailability of hydrophobic chemotherapeutic drugs such as paclitaxel (PTX). GCA-NPs were composed of quercetin (Qu)-modified liposomes (QL) coated with GCA-chitosan oligosaccharide conjugate (GCOS). The GCA-NPs thus prepared showed prolonged intestinal retention time and good GIT stability due to the presence of chitosan oligosaccharide (COS) and enhanced active transportation via intestinal apical sodium-dependent bile acid transporter (ASBT) due to the presence of GCA. GCA-NPs also efficiently inhibited intestinal P-gp induced by Qu. PTX-loaded GCA-NPs (PTX@GCA-NPs) had a particle size of 84 nm and an entrapment efficiency of 98% with good stability. As a result, the oral bioavailability of PTX was increased 19-fold compared to that of oral Taxol® at the same dose. Oral PTX@GCA-NPs displayed superior antitumor efficacy and better safety than Taxol® when administered intravenously. Conclusions Our novel drug delivery system showed remarkable efficacy in overcoming multiple limitations and is a promising carrier for oral delivery of multiple drugs, which addresses several challenges in oral delivery in the clinical context. Graphical Abstract

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Section: Methodsmentioning

confidence: 99%

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs

et al. 2022

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“…To improve the hydrophilic, long-retention/stealth effect, and biocompatibility, polyethylene glycol (PEG) was often introduced to steroid scaffolds [72]. In fact, PEGylated bile acids were synthesized to further prepare self-emulsifying drug delivery systems (SEDDSs), which could enhance the solubility and absorption of poor water-soluble antitumor agent (doxorubicin [73]) or antibiotics (itraconazole [74]), thus providing a significant enhancement of solubility and bioavailability of these small molecular drugs.…”

Section: Steroid-based Supramolecular System For Small Molecule/drug mentioning

confidence: 99%

Steroid-Based Supramolecular Systems and their Biomedical Applications: Biomolecular Recognition and Transportation

Sheng¹

2020

Chemistry and Biological Activity of Steroids

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In this chapter, the biomedical application of steroid-based compounds at "beyond the molecule"-supramolecular level-is reviewed. The renewable and economic natural steroid compounds could be employed as building blocks in the design and construction of steroid-based supramolecular systems. The specific physicochemical features (size, shape, topology, hydrophobicity, chemical modifiability, etc.) and biological properties (biocompatibility, biodegradability, bioaffinity, etc.) could be integrated into functional supramolecular systems by chemical synthesis, modification and intermolecular interactions (such as hydrogen bonding, π-π stacking, van der Waals forces, inclusion interactions, chiral interactions, electrostatic interactions, and so on). The steroid-based (supra)molecules could be employed for molecular recognition and/or be self-assembled into various functional supramolecular assemblies for biomedical applications. The specific physicochemical and biological properties, good biocompatibility, and biological activity endow the steroid-based supramolecular systems good feasibility to be employed in biomolecular recognition/sensing and biomolecular transportation (gene/drug delivery). The examples in this chapter are exemplificative of the transformation of natural steroid-based compounds into functional steroid-based supramolecular systems through molecular and supramolecular engineering technology, moreover, which may inspire the systematic study of natural product-based supramolecular (nano)materials toward future pharmaceutical and biomedical industry.

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“…Liposomes (LPs) are lipid-based nanostructures with a hydrophilic core and a lipophilic shell, where different types of drugs can be encapsulated [ 9 , 10 ]. The small size of LPs is fundamental to promote extravasation and accumulation phenomena in tumor sites.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a Controlled 5-FU Delivery Based on FZD10 Antibody-Conjugated Liposomes in Colorectal Cancer In vitro Models

et al. 2020

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The use of controlled delivery therapy in colorectal cancer (CRC) reduces toxicity and side effects. Recently, we have suggested that the Frizzled 10 (FZD10) protein, a cell surface receptor belonging to the FZD protein family that is overexpressed in CRC cells, is a novel candidate for targeting and treatment of CRC. Here, the anticancer effect of novel immuno-liposomes loaded with 5-Fluorouracil (5-FU), decorated with an antibody against FZD10 (anti-FZD10/5-FU/LPs), was evaluated in vitro on two different CRC cell lines, namely metastatic CoLo-205 and nonmetastatic CaCo-2 cells, that were found to overexpress FZD10. The anti-FZD10/5-FU/LPs obtained were extensively characterized and their preclinical therapeutic efficacy was evaluated with the MTS cell proliferation assay based on reduction of tetrazolium compound, scratch test, Field Emission Scanning Electron Microscopes (FE-SEM) investigation and immunofluorescence analysis. The results highlighted that the cytotoxic activity of 5-FU was enhanced when encapsulated in the anti-FZD10 /5-FU/LPs at the lowest tested concentrations, as compared to the free 5-FU counterparts. The immuno-liposomes proposed herein possess a great potential for selective treatment of CRC because, in future clinical applications, they can be encapsulated in gastro-resistant capsules or suppositories for oral or rectal delivery, thereby successfully reaching the intestinal tract in a minimally invasive manner.

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Mechanism of hepatic targeting via oral administration of DSPE–PEG–cholic acid-modified nanoliposomes

Cited by 18 publications

References 37 publications

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs

Steroid-Based Supramolecular Systems and their Biomedical Applications: Biomolecular Recognition and Transportation

Effectiveness of a Controlled 5-FU Delivery Based on FZD10 Antibody-Conjugated Liposomes in Colorectal Cancer In vitro Models

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