Mechanism of granuloma formation in sarcoidosis

Sakthivel, Priya; Bruder, Dunja

doi:10.1097/moh.0000000000000301

Cited by 125 publications

(108 citation statements)

References 37 publications

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“…Granulomatous inflammation is associated with substantial pathology; in the extreme, it can arise in the absence of a detectable foreign stimulus, thus constituting the pathology by itself, as it is the case of sarcoidosis …”

Section: Granulomatous Responses: An Introductionmentioning

confidence: 99%

“…7 Granulomatous inflammation is associated with substantial pathology; in the extreme, it can arise in the absence of a detectable foreign stimulus, thus constituting the pathology by itself, as it is the case of sarcoidosis. 8 As attested by the existence of nonimmunological granulomas (perhaps better called "nonadaptive granulomas"), innate immunity mechanisms can suffice to drive granulomatous responses.…”

Section: G R An Ulomatous Re S P On S E S: An Introductionmentioning

confidence: 99%

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Granulomatous responses in larval taeniid infections

Díaz

Sagasti

Casaravilla

2018

Parasite Immunology

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Granulomas are responses to persistent nonliving bodies or pathogens, centrally featuring specialized macrophage forms called epithelioid and multinucleated giant cells. The larval stages of the cestode parasites of the Taeniidae family (Taenia, Echinococcus) develop for years in fixed tissue sites in mammals. In consequence, they are targets of granulomatous responses. The information on tissue responses to larval taeniids is fragmented among host and parasite species and scattered over many decades. We attempt to draw an integrated picture of these responses in solid tissues. The intensity of inflammation around live parasites spans a spectrum from minimal to high, parasite vitality correlating with low inflammation. The low end of the inflammatory spectrum features collagen capsules proximal to the parasites and moderate distal infiltration. The middle of the spectrum is dominated by classical granulomatous responses, whereas the high end features massive eosinophil invasions. Across the range of parasite species, much observational evidence suggests that eosinophils are highly effective at killing larval taeniids in solid tissues, before and during chronic granulomatous responses. The evidence available also suggests that these parasites are adapted to inhibit host granulomatous responses, in part through the exacerbation of host regulatory mechanisms including regulatory T cells and TGF-β.

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Section: Granulomatous Responses: An Introductionmentioning

confidence: 99%

Section: G R An Ulomatous Re S P On S E S: An Introductionmentioning

confidence: 99%

Granulomatous responses in larval taeniid infections

Díaz

Sagasti

Casaravilla

2018

Parasite Immunology

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“…In addition, activated histiocytes ingest infectious agents, antigens, and foreign substances, playing an important role in their elimination. The inflammatory milieu and cellular composition of granulomas overall have been well described …”

Section: Introductionmentioning

confidence: 99%

“…In the case of infections, granuloma development is triggered by protracted or failed clearance of poorly degradable antigens, as a protective mechanism to prevent dissemination …”

Section: Introductionmentioning

confidence: 99%

Granulomatous inflammation in BK polyomavirus–associated nephropathy

Zhang

Ahmed

Haririan

et al. 2018

Transplant Infectious Dis

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Evolving BK polyomavirus-associated nephropathy (BKPyVAN) is characterized by tubulointerstitial inflammation that closely resembles acute T-cell-mediated allograft rejection if tubulitis is significant. The cellular composition of the inflammation varies during the course of BKPyVAN, and clusters of plasma cells may herald resolution of the infection. Less commonly, BKPyVAN can present with a predominance of histiocytes and granuloma formation. Granulomatous interstitial nephritis is uncommon in biopsies of either native or transplant kidneys. In both settings, this distinctive type of inflammatory response requires a systematic approach with careful clinicopathological assessment to determine its etiology. We present three patients with granulomatous BKPyVAN in the first year post-transplantation. These allograft biopsies at 4, 6, and 12 months post-transplant exemplify spontaneously resolving BKPyVAN, resolving infection after immunosuppression reduction, and early BKPyVAN, respectively. In immunosuppressed patients, BKPyVAN should be added to the relatively broad differential diagnosis of granulomatous tubulointerstitial nephritis.

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“…2,4 IL-17 is involved in numerous other autoimmune processes, including ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis. 2 Though some studies have suggested that IL-17 inhibition may be a mechanism of treatment for sarcoidosis,…”

Section: Brief Articlesmentioning

confidence: 99%

Sarcoidosis Developing During Secukinumab Therapy: Case Report

Nyckowski¹,

Ceilley

Wilson³

2017

J of Skin

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Introduction: Sarcoidosis is a systemic granulomatous inflammatory disease with an unknown etiology and complex pathogenesis. Existing literature supports the relationship of new-onset sarcoidosis with the use of a several biologic agents. Since the skin is the second most commonly involved organ in sarcoidosis and often precedes systemic involvement, dermatologists must be able to recognize its non-specific clinical presentation.Case Report: We present a 45 year old female with psoriatic arthritis who developed biopsy proven cutaneous sarcoidal granulomas with pulmonary involvement shortly after initiating secukinumab for treatment of psoriatic arthritis. Despite discontinuation of secukinumab, the sarcoidosis has persisted.Discussion: This is the first case report of secukinumab, or any IL-17 inhibitor related sarcoidosis that we are aware of in the literature. Dermatologists should be aware of this as a possible side effect of secukinumab use. As the research on the role of IL-17 in the pathogenesis of sarcoidosis continues to develop, the implications of this side effect of IL-17 inhibition may have important future implications.

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Mechanism of granuloma formation in sarcoidosis

Cited by 125 publications

References 37 publications

Granulomatous responses in larval taeniid infections

Granulomatous responses in larval taeniid infections

Granulomatous inflammation in BK polyomavirus–associated nephropathy

Sarcoidosis Developing During Secukinumab Therapy: Case Report

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