Mechanism of GM-CSF stimulation of neutrophils

Immunomodulation by colony-stimulating factors

“…GM-CSF induced morphological changes in human PMN in vitro such as the extrusion of filamentous fflopodia, polarization and the development of intraceUular vesicles (Zeck-Kapp et al 1989;Coffey 1989). GM-CSF seems to have a direct, but slow effect on neutrophil F-actin polymerization as seen in vitro, and also primes neutrophils for F-actin polymerization.…”