Mechanism of curcumin resistance to human cytomegalovirus in HELF cells

Lv, Yali; An, Zhuoling; Chen, Hui; Wang, Zihui

doi:10.1186/1472-6882-14-284

Cited by 22 publications

(12 citation statements)

References 27 publications

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“…Another highly prevalent Herpesviridae member is the human cytomegalovirus (HCMV). As shown for HSV-1, curcumin leads to a decreased IE gene expression during HCMV infections (Lv et al, 2014). This is probably caused by curcumin downregulating the cellular heat shock protein 90, a protein needed for HCMV IE gene expression (Lv et al, 2015).…”

Section: Antiviral Activities Of Curcuminmentioning

confidence: 73%

Anti-infective Properties of the Golden Spice Curcumin

et al. 2019

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The search for novel anti-infectives is one of the most important challenges in natural product research, as diseases caused by bacteria, viruses, and fungi are influencing the human society all over the world. Natural compounds are a continuing source of novel anti-infectives. Accordingly, curcumin, has been used for centuries in Asian traditional medicine to treat various disorders. Numerous studies have shown that curcumin possesses a wide spectrum of biological and pharmacological properties, acting, for example, as anti-inflammatory, anti-angiogenic and anti-neoplastic, while no toxicity is associated with the compound. Recently, curcumin’s antiviral and antibacterial activity was investigated, and it was shown to act against various important human pathogens like the influenza virus, hepatitis C virus, HIV and strains of Staphylococcus , Streptococcus , and Pseudomonas . Despite the potency, curcumin has not yet been approved as a therapeutic antiviral agent. This review summarizes the current knowledge and future perspectives of the antiviral, antibacterial, and antifungal effects of curcumin.

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Section: Antiviral Activities Of Curcuminmentioning

confidence: 73%

Anti-infective Properties of the Golden Spice Curcumin

et al. 2019

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“…Curcumin inhibits the entry of the hepatitis C virus (HCV) (Chen et al, 2012;Anggakusuma et al, 2014), human norovirus (HuNoV) , viral hemorrhagic septicemia virus in fish (VHSV) (Jeong et al, 2015), and bovine herpesvirus 1 (BHV-1) (ZHU et al, 2015). Furthermore, the curcumin hinders viral genome replication and transcription of the respiratory syncytial virus (RSV) (Obata et al, 2013; and Japanese encephalitis virus (JEV) (Dutta et al, 2009), and interferes with the translation and assembly of the Epstein-Barr virus (EBV) (Hergenhahn et al, 2002), human cytomegalovirus (HCMV) (Lv et al, 2014a;Lv et al, 2014b), and human immunodeficiency virus (HIV) (Gupta et al, 2011;Ali and Banerjea, 2016). In vitro analyses revealed the antiviral action of curcumin against the SARS-CoV virus in Vero-E6 cells; this natural polyphenol could inhibit viral replication at concentrations of 3-10 µM (Wen et al, 2007).…”

Section: In Silico Models Predicting the Antiviral Effects Of Curcumin Against Sars-cov-2mentioning

confidence: 99%

Curcumin as a Potential Treatment for COVID-19

2021

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Coronavirus disease 2019 (COVID-19) is an infectious disease that rapidly spread throughout the world leading to high mortality rates. Despite the knowledge of previous diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and treatment of patients with COVID-19 is a challenge. One of the best strategies around the world to help combat the COVID-19 has been directed to drug repositioning; however, these drugs are not specific to this new virus. Additionally, the pathophysiology of COVID-19 is highly heterogeneous, and the way of SARS-CoV-2 modulates the different systems in the host remains unidentified, despite recent discoveries. This complex and multifactorial response requires a comprehensive therapeutic approach, enabling the integration and refinement of therapeutic responses of a given single compound that has several action potentials. In this context, natural compounds, such as Curcumin, have shown beneficial effects on the progression of inflammatory diseases due to its numerous action mechanisms: antiviral, anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective. These and many other effects of curcumin make it a promising target in the adjuvant treatment of COVID-19. Hence, the purpose of this review is to specifically point out how curcumin could interfere at different times/points during the infection caused by SARS-CoV-2, providing a substantial contribution of curcumin as a new adjuvant therapy for the treatment of COVID-19.

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“…Curcumin, a compound found in turmeric, has also been described to confer anti-inflammatory effects through a combination of mechanisms including inhibition of COX-2, lipoxygenase, and the NF κ B pathway [ 48 – 51 ]. In addition to anti-inflammatory effects, curcumin has also been attributed with antitumor [ 52 , 53 ], antiviral [ 54 ], and antibacterial [ 55 ] effects. Curcumin is being tested for efficacy in patients with ulcerative colitis [ 56 – 58 ].…”

Section: Current Anti-inflammatory Drugsmentioning

confidence: 99%

Marine Diterpenoids as Potential Anti‐Inflammatory Agents

González

Torres-Mendoza

Jones

et al. 2015

Mediators of Inflammation

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The inflammatory response is a highly regulated process, and its dysregulation can lead to the establishment of chronic inflammation and, in some cases, to death. Inflammation is the cause of several diseases, including rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and asthma. The search for agents inhibiting inflammation is a great challenge as the inflammatory response plays an important role in the defense of the host to infections. Marine invertebrates are exceptional sources of new natural products, and among those diterpenoids secondary metabolites exhibit notable anti-inflammatory properties. Novel anti-inflammatory diterpenoids, exclusively produced by marine organisms, have been identified and synthetic molecules based on those structures have been obtained. The anti-inflammatory activity of marine diterpenoids has been attributed to the inhibition of Nuclear Factor-κB activation and to the modulation of arachidonic acid metabolism. However, more research is necessary to describe the mechanisms of action of these secondary metabolites. This review is a compilation of marine diterpenoids, mainly isolated from corals, which have been described as potential anti-inflammatory molecules.

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Mechanism of curcumin resistance to human cytomegalovirus in HELF cells

Cited by 22 publications

References 27 publications

Anti-infective Properties of the Golden Spice Curcumin

Anti-infective Properties of the Golden Spice Curcumin

Curcumin as a Potential Treatment for COVID-19

Marine Diterpenoids as Potential Anti‐Inflammatory Agents

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