Mechanism of calmodulin inhibition of cAMP-Dependent protein kinase activation of phosphorylation kinase

Cox, D E; Meinke, Marilyn H.; Edstrom, Ronald D.

doi:10.1016/0003-9861(87)90501-7

Cited by 7 publications

(3 citation statements)

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“…Similar studies were conducted with calmodulin. Calmodulin is known to inhibit cAMP signaling [ 24 , 38 ], and reverse the effect of PDE inhibitors such as PTX. We hypothesized that administration of calmodulin may potentially inhibit synergistic effect of GT3-PTX on cAMP signaling.…”

Section: Discussionmentioning

confidence: 99%

“…We monitored peripheral blood counts to determine the effect of GT3 and PTX on the hematopoietic system. To decipher the mechanism of synergy between GT3 and PTX, we used mevalonate to reverse the effect of HMGCR inhibition by GT3 and calmodulin to reverse phosphodiesterase inhibition, and calcium and cAMP signaling [ 24 , 25 ] such as PTX. Our results indicate that the increase in the radioprotective efficacy of GT3 by combining it with PTX was due to PDE inhibition, an effect that was reversed by calmodulin administration.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling

et al. 2013

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Purpose. This study was designed to determine the efficacy and mechanisms of radioprotection by the combination of gamma-tocotrienol (GT3) and pentoxifylline (PTX) against acute radiation injury. Materials and Methods. Post-irradiation survival was monitored to determine the most efficacious dose and time of administration of PTX. Dose reduction factor (DRF) was calculated to compare the radioprotective efficacy of the combination. To determine the mechanism of synergistic radioprotection by the combination, mevalonate or calmodulin were coadministered with the GT3-PTX combination. Mevalonate was used to reverse the inhibitory effect of GT3 on 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), and calmodulin was used to reverse the inhibition of phosphodiesterase (PDE) by PTX. Results. The combination was most effective when 200 mg/kg of PTX was administered 15 min before irradiation along with 200 mg/kg of GT3 (−24 h) and resulted in a DRF of 1.5. White blood cells and neutrophil counts showed accelerated recovery in GT3-PTX-treated groups compared to GT3. Mevalonate had no effect on the radioprotection of GT3-PTX; calmodulin abrogated the synergistic radioprotection by GT3-PTX. Conclusion. The mechanism of radioprotection by GT3-PTX may involve PDE inhibition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling

et al. 2013

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“…Αυτές μπορούν πλέον να εκφράσουν την δραστηριότητα κινάσης που διαθέτουν. Αποτέλεσμα της έκφρασης αυτής της δραστηριότητας αποτελεί η φωσφορυλίωση και ενεργοποίηση της κινάσης της φωσφορυλάσης (Cox et al 1987 (Rail et al 1956, Rail and Shutherland 1961, Poshner et al 1965, Drummond et al 1966, DeLange et al 1968, Hers 1976, Krebs and Beavo 1979, Edelman et al 1987, Larner 1990.…”

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Ο Ρολος Του Κυκλικου Αδενοσινομονοφωσφορικου Οξεος (Camp) Στον Καταβολισμο Του Γλυκογονου Στα Λυσοσωματα. Μελετη Της Επιδρασης Παραγοντων Που Τροποποιουν Τονμεταβολισμο Των Υδατανθρακων Στα Ηπατικα Κυτταρα

Καλαμιδασ¹

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Είδη κυττάρων του ήπατος Ηπατικά κύτταρα ή ηπατοκύτταρα Κυτταροπλασματική μεμβράνη Πυρήνας * Ενδοπλασματικό δίκτυο Τραχύ ενδοπλασματικό δίκτυο Ριβοσώματα Σύνθεση και μεταφορά των πρωτεϊνών Σύνθεση του ολιγοσακχαρίτη και των Ν-γλυκοπρωτεϊνών Λείο ενδοπλασματικό δίκτυο Σύμπλεγμα Golgi Μιτοχόνδρια / Λυσοσώματα Γενικοί χαρακτήρες των λυσοσωμάτων Βιοσύνθεση λυσοσωματικών ενζύμων -πρωτογενή λυσοσώματα Σχηματισμός του ιχνηθέτη αναγνώρισης των λυσοσωματικών ενζύμων Υποδοχείς της 6-φωσφορικής μανόζης (MPRs) Ανεξάρτητος απο κατιόντα υποδοχέας (CI-MPR) Εξαρτημένος απο κατιόντα υποδοχέας (CD-MPR) Η μεταφορά των ιχνηθετημένων λυσοσωματικών ενζύμων απο το Golgi στα λυσοσώματα Ετεροφαγοσώματα και ετερολυσοσώματα Αυτοφαγοσώματα και αυτολυσοσώματα Διάθεση των προϊόντων της πέψης των υλικών που εγκλείονται μέσα στα λυσοσώματα Βιολογική σημασία της λειτουργίας των λυσοσωμάτων 9

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Regulation of Muscle Glycogenolysis

Edstrom¹,

Meinke²,

Gurnack³

et al. 1990

Control of Metabolic Processes

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Mechanism of calmodulin inhibition of cAMP-Dependent protein kinase activation of phosphorylation kinase

Cited by 7 publications

References 31 publications

Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling

Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling

Regulation of Muscle Glycogenolysis

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