Mechanism of cadmium-induced nephrotoxicity

Bautista, Claudia J.; Arango, Nidia; Plata, Consuelo; Mitre-Aguilar, Irma B.; Trujillo, Joyce; Ramírez, Victoria

doi:10.1016/j.tox.2024.153726

Cited by 7 publications

(1 citation statement)

References 141 publications

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“…Our analysis identified a significant positive association between KIM-1 levels and six xenobiotics (boron, cadmium, cesium, lithium, selenium, and zinc). While the mechanisms for all six associations require further investigation, existing literature supports the potential nephrotoxic effects of the first two: boron and cadmium 32 , 33 .…”

Section: Discussionmentioning

confidence: 99%

Metal concentrations and KIM-1 levels in school-aged children: a cross-sectional study

Mendoza‐Cano,

Ríos‐Silva,

Gonzalez-Curiel

et al. 2024

Sci Rep

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Environmental exposure to heavy metals and metalloids, originating from sources such as mining and manufacturing activities, has been linked to adverse renal effects. This cross-sectional study assessed children's exposure to these elements and its association with urinary kidney injury molecule-1 (KIM-1). We analyzed data from 99 school-aged children residing in nine localities within the state of Colima, Mexico, during the latter half of 2023. Levels of 23 metals/metalloids and urinary KIM-1 were measured using inductively coupled plasma mass spectrometry (ICP-MS) and enzyme-linked immunosorbent assay, respectively. Detectable levels of these contaminants were found in over 91% of participants, with varied exposure profiles observed across locations ($$p$$ p = 0.019). After adjusting for confounding factors like gender, age, and locality, higher levels of six metals/metalloids (boron, cadmium, cesium, lithium, selenium, zinc) were significantly associated with increased KIM-1 levels. Tailored mitigation efforts are crucial to protect children from regional pollutant burdens. However, limitations exist, as our study did not capture all potential factors influencing heavy metal/metalloid and KIM-1 levels.

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Section: Discussionmentioning

confidence: 99%