Mechanism of Ca2+ release at fertilization in mammals

Swann, Karl; Parrington, John

doi:10.1002/(sici)1097-010x(19991015)285:3<267::aid-jez10>3.0.co;2-p

Cited by 85 publications

(53 citation statements)

References 69 publications

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“…The mechanism underlying Ins(1,4,5)P 3 production in eggs at the time of fertilization is still intensely debated. Similarly, the nature of the sperm factor(s) inducing Ca 2+ release at fertilization remains elusive, although several competing groups agree that it must be a protein, possibly a form of phospholipase C or an activator of it (see Stricker, 1999;Swann and Parrington, 1999;Parrington et al, 2000;McDougall et al, 2000;Nixon et al, 2000;Runft and Jaffe, 2000;Mehlmann et al, 2001;Jaffe et al, 2001;Carroll, 2001;Runft et al, 2002). Very recently, a mammalian sperm factor was characterized and found to be a new form of PLC [PLCζ (Saunders et al, 2002)].…”

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confidence: 99%

Calcium wave pacemakers in eggs

Dumollard

Carroll

Dupont

et al. 2002

Journal of Cell Science

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During the past 25 years, the characterization of sperm-triggered calcium signals in eggs has progressed from the discovery of a single calcium increase at fertilization in the medaka fish to the observation of repetitive calcium waves initiated by multiple meiotic calcium wave pacemakers in the ascidian. In eggs of all animal species, sperm-triggered inositol (1,4,5)-trisphosphate[Ins(1,4,5)P3] production regulates the vast array of calcium wave patterns observed in the different species. The spatial organization of calcium waves is driven either by the intracellular distribution of the calcium release machinery or by the localized and dynamic production of calcium-releasing second messengers. In the highly polarized egg cell, cortical endoplasmic reticulum (ER)-rich clusters act as pacemaker sites dedicated to the initiation of global calcium waves. The extensive ER network made of interconnected ER-rich domains supports calcium wave propagation throughout the egg. Fertilization triggers two types of calcium wave pacemakers depending on the species: in mice, the pacemaker site in the vegetal cortex of the egg is probably a site that has enhanced sensitivity to Ins(1,4,5)P3; in ascidians, the calcium wave pacemaker may rely on a local source of Ins(1,4,5)P3 production apposed to a cluster of ER in the vegetal cortex.

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confidence: 99%

Calcium wave pacemakers in eggs

Dumollard

Carroll

Dupont

et al. 2002

Journal of Cell Science

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“…At fertilisation sperm injects a sperm factor into the egg that, by itself, induces the two meiotic pacemakers of ascidians (Kyozuka et al, 1998;McDougall et al, 2000a) and the pacemaker of mice (Swann and Parrington, 1999). A candidate for the sperm factor has been recently identified in mammals as a novel form of phospholipase C (PLC) called PLCf Cox et al, 2002).…”

Section: Three Ca 2+ Wave Pacemakers In a Single Cellmentioning

confidence: 99%

“…It may be a PLCc or an activator of PLCc (Runft and Jaffe, 2000). Since this topic has been discussed extensively it will not be detailed here (Swann and Parrington, 1999;Nixon et al, 2000;McDougall et al, 2000a;McDougall et al, 2000b;Runft et al, 2002;Dumollard et al, 2002).…”

Section: Three Ca 2+ Wave Pacemakers In a Single Cellmentioning

confidence: 99%

Fertilisation calcium signals in the ascidian egg

Dumollard

McDougall

Rouvière

et al. 2004

Biology of the Cell

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The egg of ascidians (urochordate), as virtually all animal and plant species, displays Ca 2+ signals upon fertilisation. These Ca 2+ signals are repetitive Ca 2+ waves that initiate in the cortex of the egg and spread through the whole egg interior. Two series of Ca 2+ waves triggered from two distinct Ca 2+ wave pacemakers entrain the two meiotic divisions preceding entry into the first interphase. The second messenger inositol (1,4,5) trisphosphate (IP3) is the main mediator of these global Ca 2+ waves. Other Ca 2+ signalling pathways (RyR and NAADPR) are functional in the egg but they mediate localised cortical Ca 2+ signals whose physiological significance remains unclear. The meiosis I Ca 2+ wave pacemaker is mobile and relies on intracellular Ca 2+ release from the endoplasmic reticulum (ER) induced by a large production of IP3 at the sperm aster site. The meiosis II Ca 2+ wave pacemaker is stably localised in a vegetal protrusion called the contraction pole. It is probable that a local production of IP3 in the contraction pole determines the site of this second pacemaker while functional interactions between ER and mitochondria regulate its activity. Finally, a third ectopic pacemaker can be induced by a global increase in IP3, making the ascidian egg a unique system where three different Ca 2+ wave pacemakers coexist in the same cell.

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“…In almost all species studied, egg activation is induced by an increase in the concentration of intracellular calcium ions (Ca 2þ ) (Stricker 1999). However, the mechanism whereby the sperm triggers the release of Ca 2þ in the egg has been a subject of controversy over recent decades, with opinion divided as to whether egg activation is initiated by a surface interaction between a sperm ligand and an egg receptor, or by a cytosolic 'sperm factor' that is released into the egg from the sperm during gamete fusion (Evans & Kopf 1998, Swann & Parrington 1999.…”

Section: Introductionmentioning

confidence: 99%

Phospholipase Cζ, the trigger of egg activation in mammals, is present in a non-mammalian species

Coward¹,

Ponting²,

Chang³

et al. 2005

Reproduction

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The activation of the egg to begin development into an embryo is triggered by a sperm-induced increase in intracellular egg Ca 21 . There has been much controversy about how the sperm induces this fundamental developmental event, but recent studies suggest that, in mammals, egg activation is triggered by a testis-specific phospholipase C: PLCz. Since the discovery of PLCz, it has been unclear whether its role in triggering egg activation is common to all vertebrates, or is confined to mammals. Here, we demonstrate for the first time that PLCz is present in a non-mammalian vertebrate. Using genomic and cDNA databases, we have identified the cDNA encoding a PLCz orthologue in the domestic chicken that, like the mammalian isoforms, is a testis-specific gene.

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Mechanism of Ca2+ release at fertilization in mammals

Cited by 85 publications

References 69 publications

Calcium wave pacemakers in eggs

Calcium wave pacemakers in eggs

Fertilisation calcium signals in the ascidian egg

Phospholipase Cζ, the trigger of egg activation in mammals, is present in a non-mammalian species

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