Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B 1 –DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin

Antioxidants and Inflammatory Disease: Synthetic and Natural Antioxidants with Anti-Inflammatory Activity

“…[63,64]. Furthermore, natural or synthetic hydroxycoumarin derivatives have been found to possess antioxidant activity, inhibit lipid peroxidation, scavenge hydroxyl radicals, scavenge superoxide radicals, and scavenge hypochlorous acid [65] as well as the following: (i) efficient scavenging of the oxygen radicals [65], (ii) prevention of the formation of ADP (adenosyldiphosphate)-perferryl leading to the cessation of the formation of oxygen radicals [66], and (iii) inhibition of cytochrome P-450-linked mixed function oxidases [67].…”

Design and Synthesis of Novel Pegylated 4‐Methylcoumarins

“…Considering the proven antioxidant properties of 4-methylcoumarins, (11,12) we designed this project to combine the properties of PEGs with these coumarins to make them water soluble so that their applications may be explored in various sectors. 4-Methylcoumarins have been synthesized (Scheme 1) starting from resorcinol (1 or 2-methylresorcinol, 2) and diethyl 2-acetylglutarate (3).…”

Biocatalytic Synthesis of Novel Partial Esters of a Bioactive Dihydroxy 4-Methylcoumarin by Rhizopus oryzae Lipase (ROL)

“…Acetyl CoA-independent protein acetylation is also known, but is restricted to the action of aspirin-like drugs that would readily acetylate cyclooxygenase resulting in the inhibition of prostaglandin synthesis and, thus, induce anti-inflammatory effects [14]. Through extensive studies, we identified a microsomal enzyme, protein transacetylase (TAase) in mammalian cells and tissues, catalysing the transfer of acetyl groups from 7,8-diacetoxy-4-methylcoumarin (DAMC) to certain receptor proteins, viz., cytosolic glutathione S-transferase (GST), cytochrome P-450-linked mixed function oxidases (MFO), Nicotinamide Adenine Dinucleotide Phosphate (NADPH) cytochrome c-reductase, protein kinase C (PKC), nitric oxide synthase (NOS), and recombinant glutamine synthetase (rGlnA1) of Mycobacterium tuberculosis, resulting in the modulation of their catalytic activities and associated physiological effects [15][16][17][18][19][20]. The rat liver and human placental microsomal TAase was later identified as calreticulin, a calcium-binding protein in the lumen of the endoplasmic reticulum and, consequently, the acetyltransferase function of calreticulin was appropriately termed calreticulin transacetylase (CRTAase) [21][22][23][24].…”