Mechanism of atopic cataract caused by eosinophil granule major basic protein

Yamamoto, Naoki; Hiramatsu, Noriko; Isogai, Sumito; Kondo, Masashi; Imaizumi, Kazuyoshi; Horiguchi, Masayuki

doi:10.1007/s00795-019-00234-5

Cited by 8 publications

(13 citation statements)

References 42 publications

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“…Cytotoxic anti‐lens epithelium‐derived growth factor is another mediator that increases the defense of the lens against abnormal proteins. Decreased superoxide dismutase activity has also been shown in the development of cataract in AD 8,9 . Cataract is seen in the subcapsular region in AD.…”

Section: Discussionmentioning

confidence: 91%

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Evaluation of lens clarity in children with atopic dermatitis: A densitometric analysis with Pentacam

Yüksel

Sevil

2020

Dermatologic Therapy

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The association of atopic dermatitis (AD) with a wide variety of ocular complications is known; however, there is no study in the literature that measured lens densitometry in pediatric patients with AD. This study aimed to investigate lens densitometry in children with AD. In order to examine ocular complications in AD, 31 pediatric patients (13 males, 18 females; mean age 12 ± 3 years) with AD and 20 healthy children (9 males, 11 females; mean age 12 ± 2 years), who presented to the dermatology clinic of Istanbul Medipol Mega University between December 2018 and May 2019 were included in this study. The diagnosis of AD was based on the UK Working Party's Diagnostic Criteria for AD. Patients receiving inhaler and systemic steroids were excluded from the study. All children were examined by the same dermatologist and ophthalmologist. The mean values of best‐corrected visual acuity, refractive error, and axial length were similar between both groups (P > .05). The lens densitometry values of zone 1, zone 2, and zone 3, as well as the average lens densitometry measurements were found statistically significantly higher in children with AD compared to the controls (P < .05 for all). This is the first study to demonstrate an increase in treatment‐independent lens densitometry in children with AD.

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Section: Discussionmentioning

confidence: 91%

“…Decreased superoxide dismutase activity has also been shown in the development of cataract in AD. 8,9 Cataract is seen in the subcapsular region in AD. Anterior subcapsular cataract is more specific in AD whereas posterior subcapsular cataract is more common.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of lens clarity in children with atopic dermatitis: A densitometric analysis with Pentacam

Yüksel

Sevil

2020

Dermatologic Therapy

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“…Yokoi et al and Yamamoto et al proposed the involvement of eosinophil granule major basic proteins (MBPs) in the pathogenesis of atopic cataracts. 6,7 MBP is an eosinophil-derived toxic protein that has been detected in the anterior capsule tissues and aqueous humor of atopic cataracts but not agerelated cataracts. 6 Biochemical studies have shown that the binding of MBP to the cell membrane (lipid bilayer) causes aggregation, fusion, and lysis of liposomes, which is the mechanism of toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Physical stimulation of the eyeball by eye rubbing, oxidative damage, chronic corticosteroid therapy, epithelial-mesenchymal transition, and toxic proteins in the aqueous humor have been reported as possible etiologies of atopic cataracts. [1][2][3][4][5][6][7] However, few reports have investigated the morphological changes in the lens because of the unique pathophysiology of atopic cataracts.…”

mentioning

confidence: 99%

Lens Thickness in Atopic Cataract: A Case-Control Study

Iida

Masuda

Sano

et al. 2023

J Cataract Refract Surg

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Purpose: To examine whether atopic cataracts are associated with thinner lenses. Setting: Department of Ophthalmology, Jikei University Hospital, Tokyo, Japan. Design: Retrospective matched case–control study. Methods: 31 eyes with atopic cataracts, 62 with nonatopic cataracts, and 31 without cataracts were analyzed. Each group was matched for age (±4 years) and sex. Results: The mean lens thickness (LT) was 3.76 ± 0.40 mm, 3.94 ± 0.49 mm, and 4.11 ± 0.40 mm in eyes with atopic cataracts, nonatopic cataracts, and normal lenses, respectively. Repeated-measures analysis of variance showed that the LT in the atopic cataract group was significantly thinner than that in the nonatopic cataract (P = .036) and normal lens (P < .001) groups. In multivariate logistic regression analysis, a thinner LT was negatively correlated with age (odds ratio [OR], 0.91; 95% CI, 0.86-0.96) and positively correlated with anterior subcapsular cataract (ASC) (OR, 5.61; 95% CI, 1.97-15.99). Atopy was not a significant factor. 24 (38.7%) of the 62 eyes with nonatopic cataracts and 24 (77.4%) of the 31 eyes with atopic cataracts had ASC. Conclusions: The lenses of eyes with atopic cataracts were thinner than those of controls. Atopic cataracts frequently present with anterior subcapsular opacity, which is associated with lens thinning.

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“…4 Nevertheless, the former are also reported in patients with AD. 5,6 ASCs are more specific to AD; in fact, their presence in the absence of AD is rare. 2 Increased lipid peroxidation and inflammatory mediators induced by chronic eye rubbing, and defects in the lens epithelium, which lead to oxidative stress, are proposed mechanisms of ASCs development in AD.…”

mentioning

confidence: 99%