Mechanism of alpha-adrenergic excitation in bovine lymphatic smooth muscle

McHale, Noel G.; Allen, J. M.; Iggulden, H. L. A.

doi:10.1152/ajpheart.1987.252.5.h873

Cited by 14 publications

(8 citation statements)

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“…Such a mechanism has also been demonstrated in ureter [ 15], pulmonary ar tery [16] and mesenteric vein [17], The ef fects of isoprenaline on lymphatic smooth muscle were opposite to those of noradrena line, i.e. a hyperpolarization, slowing of spontaneous contractions and an increase in membrane conductance [18]. The results suggested that [3-receptor activation caused an increase in an outward potassium current.…”

Section: Electrical Properties Of Lymphatic Vesselsmentioning

confidence: 61%

Lymphatic Innervation

McHale¹

1990

J Vasc Res

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Bovine mesenteric lymphatic vessels have nerves in their walls which in response to field stimulation cause an increase in freqency of spontaneous lymphatic contractions and this could be blocked by α-antagonists. When vessels were loaded with [³H]-noradrenaline, ³H-effiux was increased in response to field stimulation and this was potentiated by α₂-antagonists and depressed by α₂-agonists. Electrical activity in these vessels consisted of a single action potential which preceded each contraction. Mean resting potential was –61 mV ± 5.7 (SD). Stimulation of postsynaptic α-receptors caused a depolarization accompanied by a decrease in membrane conductance while β-receptor stimulation had the opposite effect. Lymphatic noradrenergic nerves appear to have a role in the living animal since stimulation of the sympathetic chain in anaesthetized sheep increased popliteal efferent lymph flow and this could be blocked by α-adrenergic blockers.

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Section: Electrical Properties Of Lymphatic Vesselsmentioning

confidence: 61%

Lymphatic Innervation

McHale¹

1990

J Vasc Res

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“…As mentioned above, norepinephrine generally increases CF and can also elevate tone through action on adrenergic α1 receptors (25, 81, 662, 672, 673, 675, 678, 785, 932, 1049, 1060, 1062, 1063, 1069) or in one case, α2 receptors (419). The α receptor stimulation leads to an increase in STDs (672, 1069, 1104). Stimulation of β adrenergic receptors has been reported to inhibit lymphatic contractions through outward K+ current {Allen, 1986 #2911).…”

Section: Lymphangions and The Lymphatic Pump Mechanismmentioning

confidence: 97%

Lymphatic Vessel Network Structure and Physiology

Breslin

Yang

Scallan

et al. 2018

Comprehensive Physiology

267

258

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The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease.

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“…While we have known for a few decades that calcium is required for either the electrical activity or excitation-contraction coupling that drives phasic lymphatic contractions, 53,57,58,[95][96][97][98][99][100][101][102][103] relatively little is known about the specific molecular mechanisms by which calcium regulates the lymphatic muscle contraction. However, we know that phasic lymphatic contractions require extracellular calcium and that they are inhibited by dihydropyridines, especially L-type calcium channel blockers.…”

Section: The Regulation Of Lymphatic Muscle Contraction By Calciummentioning

confidence: 99%

Molecular Regulation of Lymphatic Contractility

Muthuchamy

Zawieja

2008

Annals of the New York Academy of Sciences

111

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The lymphatic system plays critical roles in body fluid and macromolecular homeostasis, lipid absorption, immune function, and metastasis. To accomplish these tasks, the lymphatics must move lymph and its contents from the interstitial space through the lymph vessels and nodes and into the great veins. Contrary to popular belief, lymph does not passively "drain" down this pathway, because the net pressure gradients oppose flow. Instead, the lymphatics must act as both the conduits that direct and regulate lymph flow and the pumps that generate the lymph flow. Thus, to regulate lymph transport and function, both lymphatic pumping and flow resistance must be controlled. Both of these processes occur via regulation of lymphatic muscle contractions, which are classically thought to occur via the interaction of cell calcium with regulatory and contractile proteins. However, our knowledge of this regulation of lymphatic contractile function is far from complete. In this chapter we review our understanding of the important molecular mechanisms, the calcium regulation, and the contractile/regulatory proteins that control lymphatic contractions. A better understanding of these mechanisms could provide the basis for the development of better diagnostic and treatment modalities for lymphatic dysfunction. While progress has been made in our understanding of the molecular biology of lymphangiogenesis as a result of the development of potential lymphangiogenic therapeutic targets, there are currently no therapeutic agents that specifically modulate lymphatic pump function and lymph flow via lymphatic muscle. However, their development will not be possible until the molecular basis of lymphatic contractility is more fully understood.

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Mechanism of alpha-adrenergic excitation in bovine lymphatic smooth muscle

Cited by 14 publications

References 0 publications

Lymphatic Innervation

Lymphatic Innervation

Lymphatic Vessel Network Structure and Physiology

Molecular Regulation of Lymphatic Contractility

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