Mechanism of allergic rhinitis treated by Centipeda minima from different geographic areas

Abstract

Context:The coriander plant Centipeda minima (L.) A. Braun et Aschers (Compositae) is used for the treatment of allergic rhinitis.Objective: Analyze the difference of the C. minima volatile oil from 7 geographic areas and its therapeutic effect on allergic rhinitis. Materials and methods: The volatile oils from different geographic areas were extracted and analyzed, the protein and biological pathway for the treatment of allergic rhinitis were predicted by network pharmacology. Established three groups of Sprague-Dawley rat allergic rhinitis models (n ¼ 10). The treatment group was given 100 lL/nostril of 0.1% C. minima volatile oil, the blank and model groups were given the same amount of normal saline. After 15 days, serum inflammatory factors were detected by ELISA. Nasal mucosa tissues were examined by hematoxylineosin staining and immunuhistrochemistry. Results: There are differences in the content of volatile oil in the seven geographic areas. Experiments showed that the concentration of TNF-a in the serum of the administration group decreased from 63.66 ± 2.06 to 51.01 ± 4.10 (pg/mL), IL-4 decreased from 41.90 ± 3.90 to 28.68 ± 3.39 (pg/mL), IgE decreased from 22.18 ± 1.40 to 17.59 ± 1.60 (pg/mL), IL-2 increased from 314.14 ± 10.32 to 355.90 ± 10.01(pg/mL). Immunohistochemistry showed that compared with the model group, the PTGS2 and MAPK3 proteins in the administration group were significantly reduced. Discussion and conclusions: C. minima volatile oil is a multi-target and multi-pathway in the treatment of allergic rhinitis, which provides a new research basis and reference for the treatment of allergic rhinitis.

Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis

“…It has been used over the years to treat various diseases, including rheumatism, sinusitis, skin pruritus, and headaches (Figures 1(a) and 1(b) ) [ 18 ]. The Xanthii fructus has been shown to reduce mast cell-mediated allergy reactions [ 19 ], anti-inflammatory actions in lipopolysaccharide-stimulated inflammatory responses [ 20 ], and prevention of β -cell damage in type 1 diabetes [ 21 ].…”

“…In a survey conducted by An et al, the anti-inflammatory role of XF has been reported on liposaccharide-stimulated mouse peritoneal macrophages [ 20 ]. Another study discovered that XF extract shields pancreatic β -cells from cytokine-induced damage by inhibiting nuclear factor kappa-B (NK- к B) [ 21 ]. Another study has established that XF is responsible for inhibiting chronic inflammation found in airways among bronchial asthma patients.…”

Investigation of the Potential Mechanism of Alpinia officinarum Hance in Improving Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking

“…Figure 6 shows that the active ingredient in A. ofcinarum binds to the core protein primarily carbonhydrogen bond, conventional hydrogen bond, van der Waals, and others. To compare the molecular docking results, we selected resveratrol, napabucasin, thalidomide, 5fuorouracil, bosutinib, celecoxib, ulixertinib, warfarin, and rosiglitazone as positive drugs with their corresponding proteins [40][41][42][43][44][45][46][47][48]. Te active ingredient binds to AKT1, STAT3, TNF, MAPK1, ALB, and PPARG were found to be more efective than the positive drug, while binding to TP53, SRC, and EGFR was found to be slightly weaker (Table 2).…”

Assessment of the Impacts of Centipeda minima (L.) on Cell Viability, and Osteogenic Differentiation of Mesenchymal Stem Cell Spheroids

“…It has been shown to possess anti-inflammatory and antioxidant properties [ 3 ]. Moreover, Centipeda minima (L.) essential oil is a multi-target agent and provides a new research platform and represents a reference for the treatment of allergic rhinitis [ 4 ].…”