Mechanism of adsorption of actives onto microporous functionalised calcium carbonate (FCC)

Levy, Charlotte L.; Matthews, G. Peter; Laudone, Giuliano M.; Beckett, Samuel; Turner, Andrew; Schoelkopf, Joachim; Gane, Patrick

doi:10.1007/s10450-017-9880-7

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…FIB-SEM provides a detailed insight into the inner structure of FCC. The structure of the lamella and the solid starter cores is consistent with the process of FCC production explained by Levy et al [38]. Pores of various sizes and shapes can be easily distinguished.…”

Section: Discussionsupporting

confidence: 86%

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

et al. 2019

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Accurate analysis of intraparticle distribution of substances within porous drug carriers is important to optimize loading and subsequent processing. Mercury intrusion porosimetry, a common technique used for characterization of porous materials, assumes cylindrical pore geometry, which may lead to misinterpretation. Therefore, imaging techniques such as focused ion beam scanning electron microscopy (FIB-SEM) help to better interpret these results. The purpose of this study was to investigate the differences between mercury intrusion and scanning electron microscopy and to identify the limitations of each method. Porous microparticles, functionalized calcium carbonate, were loaded with bovine serum albumin and dipalmitoylphosphatidylcholine (DPPC) by solvent evaporation and results of the pore size distribution obtained by both methods were compared. The internal structure of the novel pharmaceutical excipient, functionalized calcium carbonate, was revealed for the first time. Our results demonstrated that image analysis provides a closer representation of the material distribution since it was possible to discriminate between blocked and filled pores. The physical nature of the loaded substances is critical for the deposition within the pores of functionalized calcium carbonate. We conclude, that a combination of mercury intrusion porosimetry and focused ion beam scanning electron microscopy allows for a reliable analysis of sub-micron porous structures of particulate drug carriers.

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Section: Discussionsupporting

confidence: 86%

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

et al. 2019

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“…In recent years, many researchers studied the physical stability of suspension concentrate from the microscopic level, particularly the adsorption capacity, adsorption force, and adsorption morphology of the dispersant on the surface of the original drug particles [5]. The adsorption thermodynamics and adsorption kinetics have also been used to explore the effect of the dispersant [6]. For example, Ma et al performed infrared spectroscopy, X-ray photoelectron spectroscopy, and scanning electron microscopy to study the adsorption performance of polycarboxylate dispersant on the surface of fipronil particles, and combined them with adsorption theory to explore the stability mechanism of polycarboxylate dispersant on suspension concentrate [7].…”

Section: Introductionmentioning

confidence: 99%

Adsorption Properties of Comb-Shaped Polycarboxylate Dispersant onto Different Crystal Pyraclostrobin Particle Surfaces

et al. 2020

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The stability of the suspension system of the two crystal forms of pyraclostrobin is evaluated using multiple light technology, and the adsorption performance of polycarboxylate dispersant on the surface of two different crystalline pyraclostrobin particles is compared in combination with XRD, FTIR, XPS, and SEM from the microscopic view. The adsorption kinetics and thermodynamics studies of 2700 on the surfaces of different crystalline forms of pyraclostrobin particles show that the adsorption process of 2700 on the surfaces of pyraclostrobin crystal forms II and IV conform to pseudo-second-order kinetic adsorption model. The Ea values for crystal forms II and IV are 12.93 and 14.39 kJ∙mol−1, respectively, which indicates that both adsorption processes are physical adsorption. The adsorption models of 2700 on the surfaces of pyraclostrobin crystal forms II and IV are in accordance with Langmuir adsorption isotherms. The ∆Gad values of crystal forms II and IV are negative and the ∆Sad values are positive at different temperatures. Therefore, the adsorption processes are spontaneous and accompanied by entropy increase. The results of this study provide an important theoretical basis for the selection of polycarboxylate dispersants in the suspension of pyraclostrobin. This study also provides a reference for the research of polycrystalline pesticide suspension concentrate.

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“…Functionalised calcium carbonate (FCC) is produced by etching calcium carbonate particles and re-precipitating a modified surface structure with in situ or externally supplied CO 2 in the form of carbonic acid (Ridgway et al 2004;Levy et al 2015Levy et al , 2017. Variations in the etching process produce a range of morphologies with recrystallised surfaces, consisting of incorporated hydroxyapatite (HAP) in the case of phosphoric acid, which are discretely separable dual porous systems with inter-and intra-particle porosity.…”

Section: Mineralsmentioning

confidence: 99%

Improved Interpretation of Mercury Intrusion and Soil Water Retention Percolation Characteristics by Inverse Modelling and Void Cluster Analysis

et al. 2018

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This work addresses two continuing fallacies in the interpretation of percolation characteristics of porous solids. The first is that the first derivative (slope) of the intrusion characteristic of the non-wetting fluid or drainage characteristic of the wetting fluid corresponds to the void size distribution, and the second is that the sizes of all voids can be measured. The fallacies are illustrated with the aid of the PoreXpert ® inverse modelling package. A new void analysis method is then described, which is an add-on to the inverse modelling package and addresses the second fallacy. It is applied to three widely contrasting and challenging porous media. The first comprises two fine-grain graphites for use in the next-generation nuclear reactors. Their larger void sizes were measured by mercury intrusion, and the smallest by using a grand canonical Monte Carlo interpretation of surface area measurement down to nanometre scale. The second application is to the mercury intrusion of a series of mixtures of ground calcium carbonate with powdered microporous calcium carbonate known as functionalised calcium carbonate (FCC). The third is the water retention/drainage characteristic of a soil sample which undergoes naturally occurring hydrophilic/hydrophobic transitions. The first-derivative approximation is shown to be reasonable in the interpretation of the mercury intrusion porosimetry of the two graphites, which differ only at low mercury intrusion

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Mechanism of adsorption of actives onto microporous functionalised calcium carbonate (FCC)

Cited by 8 publications

References 28 publications

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

Adsorption Properties of Comb-Shaped Polycarboxylate Dispersant onto Different Crystal Pyraclostrobin Particle Surfaces

Improved Interpretation of Mercury Intrusion and Soil Water Retention Percolation Characteristics by Inverse Modelling and Void Cluster Analysis

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