Mechanism of Acute Ischemic Stroke in Patients with Severe Middle Cerebral Artery Atherosclerotic Disease

Analysis of periinterventional complications of intracranial angioplasty and stenting: A single center experience

“…Moderate stenoses may well be hemodynamically relevant. Hemodynamic insufficiency has been identified as the most important risk factor for ischemic strokes in patients with ICAD [21]. Therefore, the efficiency of PTAS to reduce stroke risk in ICAD could probably be improved by careful assessment of the hemodynamic relevance of the stenosis by perfusion imaging and/or cerebral angiography to detect collateral vessel supply [22,23].…”

Intracranial atherosclerotic disease and acute ischaemic stroke: A review of diagnosis and management

“…18,[33][34][35] These mechanisms could occur either in isolation, or in combination with multiple lesions. 18,33 The posterior circulation may be affected by atherosclerosis of the VA, basilar artery and posterior cerebral artery (PCA), which can result in infarction distal to the stenotic lesion (Fig. 2).…”

“…Patients with ICA and MCA atherosclerosis frequently suffer cortical infarcts resulting from artery‐to‐artery embolism, as well as watershed infarcts and perforator ischaemia 18,33–35 . These mechanisms could occur either in isolation, or in combination with multiple lesions 18,33 .…”

“…14,15,17 CTP images typically show decreased cerebral blood flow (CBF), delayed mean transit time (MTT) and normal-to-increased cerebral blood volume (CBV) which occurs as a result of cerebral autoregulation via established pial collaterals. 18 An example of this CTP profile can be seen in Subfigures (a-d) of Figure 1. It is important to note that these findings are not specific to ICAD and may be associated with other causes of stroke.…”

“…Patients with ICA and MCA atherosclerosis frequently suffer cortical infarcts resulting from artery-to-artery embolism, as well as watershed infarcts and perforator ischaemia. 18,[33][34][35] These mechanisms could occur either in isolation, or in combination with multiple lesions. 18,33 The posterior circulation may be affected by atherosclerosis of the VA, basilar artery and posterior cerebral artery (PCA), which can result in infarction distal to the stenotic lesion (Fig.…”