Mechanism of action of salsolinol on tyrosine hydroxylase

Briggs, Gabrielle D.; Nagy, György M.; Dickson, Phillip W.

doi:10.1016/j.neuint.2013.09.016

Cited by 27 publications

(15 citation statements)

References 29 publications

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“…Regardless of the pathway for the action of salsolinol, the inhibitory mechanism for stress‐induced activity of the HPA axis in nursing females could also be a consequence of reduced noradrenaline release. This is in line with the latest research showing that salsolinol inhibits tyrosine hydroxylase (the rate‐limiting enzyme of the catecholamines biosynthesis) activity .…”

Section: Discussionsupporting

confidence: 90%

Suckling and Salsolinol Attenuate Responsiveness of the Hypothalamic‐Pituitary‐Adrenal Axis to Stress: Focus on Catecholamines, Corticotrophin‐Releasing Hormone, Adrenocorticotrophic Hormone, Cortisol and Prolactin Secretion in Lactating Sheep

Hasiec

Tomaszewska-Zaremba

Misztal

2014

J Neuroendocrinology

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In mammals, the responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to stress is reduced during lactation and this mainly results from suckling by the offspring. The suckling stimulus causes a release of the hypothalamic 1-metyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) (a derivative of dopamine), one of the prolactin-releasing factors. To investigate the involvement of salsolinol in the mechanism suppressing stress-induced HPA axis activity, we conducted a series of experiments on lactating sheep, in which they were treated with two kinds of isolation stress (isolation from the flock with lamb present or absent), combined with suckling and/or i.c.v infusion of salsolinol and 1-methyl-3,4-dihydro-isoqinoline (1-MeDIQ; an antagonistic analogue of salsolinol). Additionally, a push-pull perfusion of the infundibular nucleus/median eminence (IN/ME) and blood sample collection with 10-min intervals were performed during the experiments. Concentrations of perfusate corticotrophin-releasing hormone (CRH) and catecholamines (noradrenaline, dopamine and salsolinol), as well as concentrations of plasma adenocorticotrophic hormone (ACTH), cortisol and prolactin, were assayed. A significant increase in perfusate noradrenaline, plasma ACTH and cortisol occurred in response to both kinds of isolation stress. Suckling and salsolinol reduced the stress-induced increase in plasma ACTH and cortisol concentrations. Salsolinol also significantly reduced the stress-induced noradrenaline and dopamine release within the IN/ME. Treatment with 1-MeDIQ under the stress conditions significantly diminished the salsolinol concentration and increased CRH and cortisol concentrations. Stress and salsolinol did not increase the plasma prolactin concentration, in contrast to the suckling stimulus. In conclusion, salsolinol released in nursing sheep may have a suppressing effect on stress-induced HPA axis activity and peripheral prolactin does not appear to participate in its action.

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Section: Discussionsupporting

confidence: 90%

Suckling and Salsolinol Attenuate Responsiveness of the Hypothalamic‐Pituitary‐Adrenal Axis to Stress: Focus on Catecholamines, Corticotrophin‐Releasing Hormone, Adrenocorticotrophic Hormone, Cortisol and Prolactin Secretion in Lactating Sheep

Hasiec

Tomaszewska-Zaremba

Misztal

2014

J Neuroendocrinology

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“…First, salsolinol inhibits the increase in plasma noradrenaline concentration induced by immobilization stress in rats [41], and 1-MeDIQ increased the basal plasma noradrenaline concentration [42]. Second, salsolinol inhibited the tyrosine hydroxylase activity [43,44]. Considering the inhibitory properties of salsolinol, regarding to this catecholamine, we suggest that the effects of 1-MeDIQ may result from the modulation of the noradrenergic system within the central nervous system.…”

Section: Discussionmentioning

confidence: 88%

Salsolinol: a potential modulator of the activity of the hypothalamic–pituitary–adrenal axis in nursing and postweaning sheep

Hasiec

Herman

Misztal

2015

Domestic Animal Endocrinology

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“…Tóth et al () proposed that SAL influences tonic reverse transport through DA transporters and/or DA synthesis by inhibiting L‐amino acid decarboxylase (AADC) in the terminals of NEDA neurons. Furthermore, Briggs et al () reported that SAL inhibited tyrosine hydroxylase activity to reduce DA levels.…”

Section: Discussionmentioning

confidence: 99%

Effects of extracerebral dopamine on salsolinol‐ or thyrotropin‐releasing hormone‐induced prolactin (PRL) secretion in goats

Yuki

Kato

Itou

et al. 2016

Animal Science Journal

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The aim of the present study was to clarify the effect of extracerebral dopamine (DA) on salsolinol (SAL)-induced prolactin (PRL) secretion in goats. An intravenous injection of SAL or thyrotropin-releasing hormone (TRH) was given to female goats before and after treatment with an extracerebral DA receptor antagonist, domperidone (DOM), and the PRL-releasing response to SAL was compared with that to TRH. DOM alone increased plasma PRL concentrations and the PRL-releasing response to DOM alone was greater than that to either SAL alone or TRH alone. The PRL-releasing response to DOM plus SAL was similar to that to DOM alone, and no additive effect of DOM and SAL on the secretion of PRL was observed. In contrast, the PRL-releasing response to DOM plus TRH was greater than that to either TRH alone or DOM alone and DOM synergistically increased TRH-induced PRL secretion. The present results demonstrate that the mechanism involved in PRL secretion by SAL differs from that by TRH, and suggest that the extracerebral DA might be associated in part with the modulation of SAL-induced PRL secretion in goats.

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Mechanism of action of salsolinol on tyrosine hydroxylase

Cited by 27 publications

References 29 publications

Suckling and Salsolinol Attenuate Responsiveness of the Hypothalamic‐Pituitary‐Adrenal Axis to Stress: Focus on Catecholamines, Corticotrophin‐Releasing Hormone, Adrenocorticotrophic Hormone, Cortisol and Prolactin Secretion in Lactating Sheep

Suckling and Salsolinol Attenuate Responsiveness of the Hypothalamic‐Pituitary‐Adrenal Axis to Stress: Focus on Catecholamines, Corticotrophin‐Releasing Hormone, Adrenocorticotrophic Hormone, Cortisol and Prolactin Secretion in Lactating Sheep

Salsolinol: a potential modulator of the activity of the hypothalamic–pituitary–adrenal axis in nursing and postweaning sheep

Effects of extracerebral dopamine on salsolinol‐ or thyrotropin‐releasing hormone‐induced prolactin (PRL) secretion in goats

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