Mechanism of action of glycyrrhizin against Plasmodium falciparum

Antimalarial activity of the 80%methanol extract and solvent fractions of Cucumis ficifolius A. rich roots against Plasmodium berghei in mice

“…Flavonoids can make a complex with malaria protein, extracellular and other cell components, and may disturb microbial components, inactivate toxins and inhibit malarial enzymes [ 40 , 41 ]. Similarly, saponins exert their antimalarial effect by disorganization of membrane lipid rafts and cholesterol sequestration, and the formation of stable complexes with HMGB1 (high-mobility group box 1) proteins, including both human and Plasmodium [ 42 ]. The antioxidant activity of saponins [ 43 ] and phenol [ 26 ] is responsible for an antimalarial effect.…”