Mechanism of action of delta sleep-inducing peptide injected after L-dopa

Доведова, Е. Л.

doi:10.1007/bf00842387

Cited by 2 publications

(4 citation statements)

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“…Myoclonic seizures of muscles were not observed in any of the patterns. Dopamine and serotonin metabolism normalized under such conditions: MAO-A and MAO-B activities return to the initial levels [3].…”

Section: Resultsmentioning

confidence: 98%

“…Biochemically, both variants of taftsin administration were associated with suppression of MAO-A activity [2,3]. Taftsin apparently does not influence the neurochemical processes triggered by penicillin.…”

Section: Resultsmentioning

confidence: 99%

“…L-DOPA stimulates dopaminergic and reciprocally suppresses serotonin-and cholinergic processes. By contrast, DSP activates serotoninergic and suppresses adrenergic systems [2,3].…”

Section: Resultsmentioning

confidence: 99%

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Peptide correction of disturbed intercentral relations

1998

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Effects of peptides with opioid activity (8-sleep peptide, tetrapeptidamide, and taftsin) are studied in animals with disturbed intercentral relations (psychomotor excitation or penicillin epilepsy). 5-Sleep peptide and tetrapeptidamide suppress brain structure responses to photoand acoustic stimulants. All peptides alter the multisensory characteristics of the structures. In disease, peptidergic mechanisms regulate afferent flows to brain structures. Pathological states of the central nervous system have been regarded as a result of discoordination between brain structures. However, this assumption is rather abstract and allows many interpretations. According to one of them, functional interactions (or integration) of brain structures is a principal scheme of distribution and regulation of afferent flows. Distortions of such a scheme lead to disease and its restoration to correction and compensation [6]. From this viewpoint we shall regard neuropsychotropic effects of 5-sleep peptides (DSP) and tetrapeptidamide possessing opioid activity and those of taftsin, a wellknown stimulant of the central nervous system. Systemic restructuring provoked by a single injection of each of these peptides to intact animals and animals with central nervous system diseases was assessed in higher animals by bioelectric activity of the brain: electroencephalogram, evoked potentials (EP), and their analogs or reproduced EP configurations between the signals. MATERIALS AND METHODSExperiments were carded out on dogs and cats with chronically implanted electrodes. In dogs, the electrodes were implanted in the visual analyzer structures (fields O~ and O2), external geniculate body, motor field, caudate nucleus, pale globe, adjacent nucleus, and intralaminar nuclei of the thalamus. A Institute of Brain, Russian Academy of Medical Sciences, Moscow defense habit was developed in dogs: a series of 6 light flashes (2 Hz) was combined with suprathreshold electrostimulation of the fore paw between the fifth and sixth flash.Electroencephalogram and EP were recorded with a 9-circuit oscillographer (pass band up to 2000 Hz, time constant 1 sec). Similarity of EP analog configuration to configuration of EP recorded in response to sensory stimulator was the criterion for distinguishing EP analogs. The presence of EP analogs, their configuration, amplitude and time, and relation to the motor reaction were assessed.In cats, the electrodes were implanted in sensorimotor, acoustic, and visual cortical zones, in caudate nuclei, hippocampus, central medial nuclei of the thalamus, and in anterior two-hillock area.Electroencephalograms were recorded with a 16-channel encephalographer (RIS) with time constant 0.05 sec and upper pass band 150 Hz.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Peptide correction of disturbed intercentral relations

1998

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“…Stress-protective and regulating effects of 5-sleep peptide (DSP) have been extensively studied in various diseases [3][4][5][6]10,11] during the last two decades [13]; however, metabolism modifications and restructuring in the brain caused by this peptide are still little known.…”

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confidence: 99%

Cytochemical and morphological changes in cerebral neurons induced by δ-sleep peptide

Khudoerkov

1998

Bull Exp Biol Med

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Mechanism of action of delta sleep-inducing peptide injected after L-dopa

Cited by 2 publications

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Peptide correction of disturbed intercentral relations

Peptide correction of disturbed intercentral relations

Cytochemical and morphological changes in cerebral neurons induced by δ-sleep peptide

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