Mechanism of action of coumarin and silver(I)–coumarin complexes against the pathogenic yeast Candida albicans

Thati, Bhumika; Noble, Andy; Rowan, Raymond; Creaven, Bernadette S.; Walsh, Maureen; McCann, Malachy; Egan, Denise A.; Kavanagh, Kevin

doi:10.1016/j.tiv.2007.01.022

Cited by 103 publications

(92 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Coumarin (2H-1-benzopyran-2-one, or 2H-chromen-2-one) is a natural substance found in many plants; it belongs to the benzopyrone chemical class, whose derivatives possess potential antimicrobial [96,97] and antifungal activities [98]. Moreover, there are a number of commercially available coumarin-based antibiotics (novobiocin, clorobiocin and coumermycin A1), and anticoagulants (warfarin, dicoumarol).…”

Section: Ag(i) Complexes With a Variety Of Pharmaceutical Agentsmentioning

confidence: 99%

Silver coordination compounds: A new horizon in medicine

Medici

Peana

Crisponi

et al. 2016

Coordination Chemistry Reviews

240

157

View full text Add to dashboard Cite

Section: Ag(i) Complexes With a Variety Of Pharmaceutical Agentsmentioning

confidence: 99%

Silver coordination compounds: A new horizon in medicine

Medici

Peana

Crisponi

et al. 2016

Coordination Chemistry Reviews

240

157

View full text Add to dashboard Cite

“…Our previous work has focussed on the synthesis and therapeutic applications of a series of silver and copper complexes of coumarin-derived ligands [24][25][26][27][28][29]. More recently we have focused our research efforts on the preparation of a series of coumarinand quinolin-2(1H)-one-triazole-derived Schiff bases and their Cu(II) complexes [30,31].…”

Section: Introductionmentioning

confidence: 99%

Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

Creaven

Duff

Egan

et al. 2010

Inorganica Chimica Acta

Self Cite

204

View full text Add to dashboard Cite

a b s t r a c tThe condensation of substituted aromatic aldehydes with 7-amino-4-methyl-quinolin-2(1H)-one (1) has lead to the isolation of quinolin-2(1H)-one derived Schiff bases (2-14). The copper(II) complexes (2a-14a) of the ligands were also prepared, and together with their corresponding free ligands were fully characterised by elemental analyses, spectral methods (IR, 1 H and 13 C NMR, AAS, UV-Vis), magnetic and conductance measurements. The bidentate ligands coordinated to the copper(II) ion through the deprotonated phenolic oxygen and the azomethine nitrogen of the ligands in almost all cases. X-ray crystal structures of two of the complexes, 5a and 8a, confirmed the bidentate coordination mode. All of the compounds were investigated for their antimicrobial activities against the fungus, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to have excellent antiCandida activity but were inactive against Staphylococcus aureus and Escherichia coli. Selected compounds (2-8 and 2a-8a) were also screened for their in vitro anticancer potential using the human hepatic carcinoma cell line, Hep-G 2 . Several derivatives were shown to be active comparable to that of cisplatin.

show abstract

“…On the basis of this mechanism, silver can inhibit the growth of a wide variety of microorganisms such as molds, viruses, bacteria and so forth [26][27][28][29][30]. More importantly, silver nanostructures, such as silver nanoparticles, provide a large surface-area-to-volume ratio and a high fraction of surface atoms [31], which enhance the antimicrobial activity of silver, even at low concentrations [32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of antibacterial properties of Ag nanorods by electric field

Akhavan

Ghaderi

2009

Science and Technology of Advanced Materials

View full text Add to dashboard Cite

The effect of an electric field on the antibacterial activity of columnar aligned silver nanorods was investigated. Silver nanorods with a polygonal cross section, a width of 20-60 nm and a length of 260-550 nm, were grown on a titanium interlayer by applying an electric field perpendicular to the surface of a Ag/Ti/Si(100) thin film during its heat treatment at 700• C in an Ar+H 2 environment. The optical absorption spectrum of the silver nanorods exhibited two peaks at wavelengths of 350 and 395 nm corresponding to the main surface plasmon resonance bands of the one-dimensional silver nanostructures. It was found that the silver nanorods with an fcc structure were bounded mainly by {100} facets. The antibacterial activity of the silver nanorods against Escherichia coli bacteria was evaluated at various electric fields applied in the direction of the nanorods without any electrical connection between the nanorods and the capacitor plates producing the electric field. Increasing the electric field from 0 to 50 V cm −1 resulted in an exponential increase in the relative rate of reduction of the bacteria from 3.9 × 10 −2 to 10.5 × 10 −2 min −1 . This indicates that the antibacterial activity of silver nanorods can be enhanced by applying an electric field, for application in medical and food-preserving fields.

show abstract

Mechanism of action of coumarin and silver(I)–coumarin complexes against the pathogenic yeast Candida albicans

Cited by 103 publications

References 26 publications

Silver coordination compounds: A new horizon in medicine

Silver coordination compounds: A new horizon in medicine

Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

Enhancement of antibacterial properties of Ag nanorods by electric field

Contact Info

Product

Resources

About