Mechanism of action of antidepressants

Sharma, Kritika; Sundriyal, Ankush; Loshali, Aanchal; Agrawal, Mohit; Krishna, Chinnabonia Gopala; Singh, Yogendra

doi:10.1016/b978-0-323-99855-0.00011-7

Cited by 3 publications

(3 citation statements)

References 78 publications

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“…50 SSRI and MAO inhibitors have been shown to exert antidepressant effects primarily by increasing serotonin levels in key brain areas, and natural as well as synthetic compounds that enhance brain serotonin levels have been reported to possess antidepressant activity. 51,52 We found that GBP1F enhanced serotonin levels in the hippocampus, so it may be a conceivable deduction that this serotonin elevation was a participating factor in the identified behavioral antidepressant-like activity.…”

Section: Discussionmentioning

confidence: 82%

Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition

Gohar,

Ali,

Rashid

et al. 2023

DDDT

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Background and Objective Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management. Due to growing evidence of its abuse liability, there has been an incentive to synthesise potentially useful gabapentin derivatives devoid of adverse effects. A gabapentin adduct with a fluoxetine moiety, GBP1F, was assessed for any sedative, cognitive, anxiolytic, or antidepressant-like actions in murine behavioral models. Materials and Methods Selected groups of mice were used for each behavioral paradigm, and the effect of GBP1F (5, 10, and 15 mg/kg) was assessed using spontaneous locomotor activity, the tail suspension test, elevated plus maze test, and the Y maze test models. Immediately following behavioral experiments, postmortem striatal and hippocampal tissues were evaluated for the effect of GBP1F on concentrations of dopamine, DOPAC, HVA, serotonin, 5-HIAA, vitamin C, and noradrenaline using high performance liquid chromatography with electrochemical detection. Results GBP1F induced a mild suppression of locomotor activity, ameliorated anxiety and depression-like behavior, did not alter cognitive behavior, and raised serotonin and 5-HIAA concentrations in the hippocampus and striatum. GBP1F also positively enhanced dopamine and vitamin C tissue levels in the striatum. Thus, GBP1F represents a compound with anxiolytic- and antidepressant-like effects though further studies are warranted at the molecular level to focus on the precise mechanism(s) of action.

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Section: Discussionmentioning

confidence: 82%

Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition

Gohar,

Ali,

Rashid

et al. 2023

DDDT

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“…29 These receptors and associated neurotransmitter systems are targeted by various classes of antidepressants, collectively impacting mood, emotions, and brain function to alleviate symptoms of depression. 30,31 Metal-catalyzed transformations have been employed in the synthesis of antidepressants at several sites along the pathway, leading to the development of C-C, and C-N bonds and the functionalization of aromatic rings. 32 In particular, SSRIs, including sertraline and uoxetine, which are extensively used to treat depression, have been synthesized via couplings catalyzed by palladium.…”

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confidence: 99%

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confidence: 99%

Synthesis of anti-depressant molecules via metal-catalyzed reactions: a review

Kanwal,

Afzal,

Zubair

et al. 2024

RSC Adv.

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Mass Spectrometry Imaging Combined with Sparse Autoencoder Method Reveals Altered Phosphorylcholine Distribution in Imipramine Treated Wild-Type Mice Brains

Rahman,

Islam,

Islam

et al. 2024

IJMS

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Mass spectrometry imaging (MSI) is essential for visualizing drug distribution, metabolites, and significant biomolecules in pharmacokinetic studies. This study mainly focuses on imipramine, a tricyclic antidepressant that affects endogenous metabolite concentrations. The aim was to use atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI)-MSI combined with different dimensionality reduction methods to examine the distribution and impact of imipramine on endogenous metabolites in the brains of treated wild-type mice. Brain sections from both control and imipramine-treated mice underwent AP-MALDI-MSI. Dimensionality reduction methods, including principal component analysis, multivariate curve resolution, and sparse autoencoder (SAE), were employed to extract valuable information from the MSI data. Only the SAE method identified phosphorylcholine (ChoP) as a potential marker distinguishing between the control and treated mice brains. Additionally, a significant decrease in ChoP accumulation was observed in the cerebellum, hypothalamus, thalamus, midbrain, caudate putamen, and striatum ventral regions of the treated mice brains. The application of dimensionality reduction methods, particularly the SAE method, to the AP-MALDI-MSI data is a novel approach for peak selection in AP-MALDI-MSI data analysis. This study revealed a significant decrease in ChoP in imipramine-treated mice brains.

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Mechanism of action of antidepressants

Cited by 3 publications

References 78 publications

Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition

Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition

Synthesis of anti-depressant molecules via metal-catalyzed reactions: a review

Mass Spectrometry Imaging Combined with Sparse Autoencoder Method Reveals Altered Phosphorylcholine Distribution in Imipramine Treated Wild-Type Mice Brains

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