Mechanism of Acetic Acid Gustatory Repulsion in Drosophila

Rimal, Suman; Sang, Jiun; Poudel, Seeta; Thakur, Dhananjay; Montell, Craig; Lee, Youngseok

doi:10.1016/j.celrep.2019.01.042

Cited by 65 publications

(82 citation statements)

References 38 publications

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“…In the fruit fly Drosophila melanogaster, acids are sensed by gustatory neurons [1,54], and several receptor molecules have been identified that are necessary for their detection: IR76b and IR25a are required for the detection of carboxylic and mineral acids that are attractive and lead to female oviposition [55]. IR76a, IR25a, and IR56d form a receptor involved in behavioral attraction to fatty acids [56], whereas IR7a is required for behavioral aversion to acetic acid [57]. However, functional reconstitution of any of these receptors in a heterologous cell type has not been reported, although IR7a conferred acid responsiveness to sweet-sensing cells within the fruit fly [57].…”

Section: Discussionmentioning

confidence: 99%

“…IR76a, IR25a, and IR56d form a receptor involved in behavioral attraction to fatty acids [56], whereas IR7a is required for behavioral aversion to acetic acid [57]. However, functional reconstitution of any of these receptors in a heterologous cell type has not been reported, although IR7a conferred acid responsiveness to sweet-sensing cells within the fruit fly [57]. In contrast, Otop1 is well established to function as a proton channel in heterologous cells [34].…”

Section: Discussionmentioning

confidence: 99%

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Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1

Teng

Wilson²,

et al. 2019

Current Biology

142

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1

Teng

Wilson²,

et al. 2019

Current Biology

142

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“…In insects, GRs expressed in gustatory neurons acts as taste receptors, which are responsible for feeding behaviors (Dunipace et al, 2001;Scott et al, 2001). As a large and highly divergent family of ionotropic glutamate receptors in Drosophila, IRs are subdivided into "antennal IRs, " which are expressed in antennae specifically and mainly involved in olfactory recognition; and "divergent IRs, " which are found in various tissues taking responsible for sensation of taste (Jaeger et al, 2018;Lee et al, 2018;He et al, 2019;Rimal et al, 2019). Various chemosensory associated proteins in insect play diverse functions, such as those listed in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Identification of Leg Chemosensory Genes and Sensilla in the Apolygus lucorum

Zhang

et al. 2020

Front. Physiol.

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Apolygus lucorum (Hemiptera: Miridae), one of the main insect pests, causes severe damage in cotton and many other economic crops. As is well-known, legs play important roles in the chemoreception of insects. In this study, the putative chemosensory proteins in legs of A. lucorum involved in close or contact chemical communication of adult bugs were investigated using RNA transcriptome sequencing and qPCR methods. Transcriptome data of forelegs, middle legs and hind legs of adult bugs demonstrated that 20 odorant binding protein (OBP) genes, eight chemosensory protein (CSP) genes, one odorant receptor (OR) gene, one ionotropic receptor (IR) gene and one sensory neuron membrane protein (SNMP) gene were identified in legs of A. lucorum. Compared to the previous antennae transcriptome data, five CSPs, IR21a and SNMP2a were newly identified in legs. Results of qPCR analysis indicated that all these putative chemosensory genes were ubiquitously expressed in forelegs, middle legs and hind legs of bugs. Furthermore, four types of sensilla on legs of A. lucorum including sensilla trichodea (subtypes: long straight sensilla trichodea, Str1; long curved sensilla trichodea, Str2), sensilla chaetica (subtypes: sensilla chaetica 1, Sch1; sensilla chaetica 2, Sch2; and sensilla chaetica 3, Sch3), sensilla basiconca (subtypes: mediumlong sensilla basiconca, Sba1; short sensilla basiconca, Sba2) and Böhm bristles (BB) were found using scanning electron microscopy. Additionally, the largest number of sensilla was observed on hind legs, while the forelegs had the smallest number of sensilla. Our data provide valuable insights into understanding the chemoreception of legs in A. lucorum.

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“…This ovipositional preference is mediated by taste sensory neurons in the legs that respond specifically to acids (Chen and Amrein, 2017). Dedicated acid-sensing neurons in the proboscis have not been identified, although acid responses in bitter-sensing neurons have been observed (Charlu et al, 2013; Rimal et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Acetic acid activates distinct taste pathways in Drosophila to elicit opposing, state-dependent feeding responses

Devineni

Sun

Zhukovskaya

et al. 2019

eLife

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Taste circuits are genetically determined to elicit an innate appetitive or aversive response, ensuring that animals consume nutritious foods and avoid the ingestion of toxins. We have examined the response of Drosophila melanogaster to acetic acid, a tastant that can be a metabolic resource but can also be toxic to the fly. Our data reveal that flies accommodate these conflicting attributes of acetic acid by virtue of a hunger-dependent switch in their behavioral response to this stimulus. Fed flies show taste aversion to acetic acid, whereas starved flies show a robust appetitive response. These opposing responses are mediated by two different classes of taste neurons, the sugar- and bitter-sensing neurons. Hunger shifts the behavioral response from aversion to attraction by enhancing the appetitive sugar pathway as well as suppressing the aversive bitter pathway. Thus a single tastant can drive opposing behaviors by activating distinct taste pathways modulated by internal state.

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Mechanism of Acetic Acid Gustatory Repulsion in Drosophila

Cited by 65 publications

References 38 publications

Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1

Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1

Identification of Leg Chemosensory Genes and Sensilla in the Apolygus lucorum

Acetic acid activates distinct taste pathways in Drosophila to elicit opposing, state-dependent feeding responses

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