Mechanism insight on licorice flavonoids release from Carbopol hydrogels: Role of “release steric hindrance” and drug solubility in the release medium

Wang, Zhuxian; Hu, Yi; Xue, Yi; Zhu, Zhaoming; Wu, Yufan; Zeng, Quanfu; Wang, Yuan; Han, Haoyang; Zhang, Haixiang; Shen, Chunyan; Yi, Kuiyan; Jiang, Cuiping; Liu, Li; Zhu, Hongxia; Li, Hui; Liu, Qiang; Shen, Qun

doi:10.1016/j.ejps.2022.106307

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…At the same time, water and citral molecules compete for the hydrogen bond action sites on the hydrogel, resulting in the release of citral molecules into the gel layer. Under the effect of the difference in citral concentration inside and outside the hydrogels, citral molecules are finally released from the carrier through the gel layer. − In view of the swelling level and intelligent responsiveness, AA/BC-4C and AA/BC-6C were mainly selected for subsequent research. Figure a shows the release curves at pH 6.5 and 3.0.…”

Section: Resultsmentioning

confidence: 99%

Novel Double Cross-Linked Acrylic Acid/Bagasse Cellulose Porous Hydrogel for Controlled Release of Citral and Bacteriostatic Effects

Han

Zhu

Cheng

2023

ACS Appl. Mater. Interfaces

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In this study, double cross-linked acrylic acid/bagasse cellulose (AA/BC) porous hydrogels were first prepared using cold plasma (CP) technology instead of chemical initiators. The structure and properties of porous hydrogels, as well as the controlled release and bacteriostatic application as functional carriers, were investigated. Results showed that a novel double cross-linked hydrogel had been successfully synthesized by utilizing •OH and H+ produced during plasma discharge. The acrylic acid (AA) monomers were successfully grafted onto the main chains of bagasse cellulose (BC), forming a porous three-dimensional network structure. The AA/BC porous hydrogels showed excellent swelling levels and intelligent responses. The release of citral in hydrogel inclusion compounds embedded with citral was controlled by adjusting the pH, and the slow release period was about 2 days. The inclusion compounds presented strong bacteriostatic effects against Escherichia coli and Staphylococcus aureus, extending the shelf life of fruits for about 4 days. Therefore, it can be concluded that CP technology is considered to be an efficient and environmental-friendly initiation technology for preparing hydrogels. The potential application of hydrogel inclusion compounds in the food field is expanded.

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Section: Resultsmentioning

confidence: 99%

Novel Double Cross-Linked Acrylic Acid/Bagasse Cellulose Porous Hydrogel for Controlled Release of Citral and Bacteriostatic Effects

Han

Zhu

Cheng

2023

ACS Appl. Mater. Interfaces

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“…PBS (pH 7.4)/PEG 400 (v/v, 80/20) buffer is used as the receptor medium, and the receptor medium is continuously stirred at 300 rpm. 46,47 At 0.5 h, 1 h, 2 h, 4 h, 6 h, 8 h, 10 h, 12 h and 24 h, 0.5 mL samples are taken out, filtered through a 0.22 μm nylon membrane, and analyzed by HPLC after adding fresh preheated medium.…”

Section: Methodsmentioning

confidence: 99%

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

Liang,

Hu,

Wang

et al. 2023

CrystEngComm

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“…Topical formulations to treat psoriasis, or to keep breast cancer under control, were developed [ 191 , 192 ]. Due to its lipolytic character, the transport system is of a lipidic nanocarrier or niosome type [ 192 , 193 , 194 ]. Flavonols —quercetin is one of the most intensively studied and common flavonols found in nature; because this flavonoid shows a poor permeability in normal or excised human skin, it has been incorporated into various delivery systems, including nanoemulsions, nanocapsules, lipid nanoparticles, and microemulsions, to increase skin solubility and permeability [ 139 , 195 ].…”

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.

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Mechanism insight on licorice flavonoids release from Carbopol hydrogels: Role of “release steric hindrance” and drug solubility in the release medium

Cited by 10 publications

References 34 publications

Novel Double Cross-Linked Acrylic Acid/Bagasse Cellulose Porous Hydrogel for Controlled Release of Citral and Bacteriostatic Effects

Novel Double Cross-Linked Acrylic Acid/Bagasse Cellulose Porous Hydrogel for Controlled Release of Citral and Bacteriostatic Effects

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

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