2011
DOI: 10.4049/jimmunol.1101778
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Mechanism for Pre-B Cell Loss in VH-Mutant Rabbits

Abstract: Pre-BCR signaling is a critical checkpoint in B cell development in which B-lineage cells expressing functional IgH μ-chain are selectively expanded. B cell development is delayed in mutant ali/ali rabbits because the a-allotype encoding VH1 gene, which is normally used in VDJ gene rearrangements in wt rabbits, is deleted, and instead, most B-lineage cells use the a-allotype encoding VH4 gene [VH4(a)], which results in a severe developmental block at the pre-B cell stage. We found that VH4(a)-utilizing pre-B c… Show more

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