Mechanism for hormone-induced alterations in serum ceruloplasmin

Evans, Gerald W.; Cornatzer, NF; We, Cornatzer

doi:10.1152/ajplegacy.1970.218.3.613

Cited by 61 publications

(23 citation statements)

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“…Estrogen is known to result in higher Cp activity in rats (Evans et al, 1970a). Pregnancy and lactation impacts Cp levels as both result in higher activity in humans, rats, and most other mammals (Seal, 1964;Evans et al, 1970a;DiSilvestro, 1986). Interestingly, we did not detect significant elevation in Cp between young female adult and age-matched lactating mice in these studies; whereas, in rats lactation approximately doubled plasma Cp activity.…”

Section: Discussioncontrasting

confidence: 57%

“…Cp activity can also be impacted by inflammation since Cp is an acute phase protein and responds transcriptionally to several cytokines. Estrogen is known to result in higher Cp activity in rats (Evans et al, 1970a). Pregnancy and lactation impacts Cp levels as both result in higher activity in humans, rats, and most other mammals (Seal, 1964;Evans et al, 1970a;DiSilvestro, 1986).…”

Section: Discussionmentioning

confidence: 99%

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Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice

Prohaska

Broderius

2006

Comparative Biochemistry and Physiology Part B: Biochemistry an

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In an attempt to identify a sensitive and improved marker of mammalian copper status during neonatal development experiments compared two plasma cuproenzymes, peptidylglycine α-amidating monooxygenase (PAM ), an enzyme involved in peptide posttranslational activation, to ceruloplasmin (Cp), a ferroxidase involved in iron mobilization. Dietary Cu deficiency (Cu−) was studied in dams and offspring at postnatal age 3 (P3), P12, and P28. Rodent Cp activity rose during lactation whereas PAM activity fell. Reduction in Cp activity was more severe than reduction in PAM activity in Cu− offspring and dams. Cp activity was greater in rats than mice whereas PAM activity was similar in adults but greater in mouse than rat pups. Both cuproenzymes changed during neonatal development and when dietary copper was limiting. With proper controls, each enzyme can be used to assess copper status.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice

Prohaska

Broderius

2006

Comparative Biochemistry and Physiology Part B: Biochemistry an

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“…Others have shown that serum Cu increases at estrus in response to estradiol (Evans et al 1970;Weiner and Cousins 1983). (Table 6) Dietary concentrations of Fe, Zn and Mn were within ranges recommended for cattle (NRC 1984) and not expected to limit growth or reproductive function.…”

Section: Sodium Sulfur and Coppermentioning

confidence: 84%

Serum mineral concentrations in relation to estrus and conception in beef heifers and cows fed conserved forage

Small¹,

Charmley²,

Rodd³

et al. 1997

Can. J. Anim. Sci.

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Small, J. A., Charmley, E., Rodd, A. V. and Fredeen, A. H. 1997. Serum mineral concentrations in relation to estrus and conception in beef heifers and cows fed conserved forage. Can. J. Anim. Sci. 77: 55-62. A study was undertaken to examine serum mineral concentrations in relation to estrus and first service conception (FSC) in beef cattle fed conserved forage. Blood samples were taken from yearling nulliparous heifers, and suckled 2-yr-old primiparous heifers and multiparous cows at first service which occurred within 12 h of observed standing heat and 21 d after. Serum was analyzed for calcium (Ca), phosphorus (P), magnesium (Mg), potassium (K), sulfur (S), sodium (Na), iron (Fe), copper (Cu), manganese (Mn), zinc (Zn) and boron (B) concentrations by ICAP. Heifers were fed in four groups based on parity and given 3.0 and 2.5 kg hd d -1 of a grain supplement, respectively, plus free-choice grass hay (1.71% K; 0.20% P; 8% protein; 41% ADF). Cows were individually fed ad libitum (21 g kg -1 body weight) grass-legume silage (2.82% K; 0.35% P; 14% protein, 34% ADF). Heifers and cows gained body weight over the breeding season and at turnout had body condition scores of 5 to 6 for heifers and 6 to 7 for cows. Rates of FSC were 53% (10/19), 48% (10/21) and 64% (18/28) for nulli-, primi-and multiparous groups, respectively. Serum Ca, Na, S, Cu, Fe, Zn and Mn did not differ (P > 0.05) between FSC groups, but Na and Cu were higher (P < 0.05) at estrus than at day 21, especially in nulliparous heifers. Concentrations of serum Mg were low (< 0.74 mmol L -1 ) and K high (> 4.5 mmol L -1 ) in heifers and cows but in nulliparous heifers only, serum Mg and K were lowest (P < 0.05) at estrus for those that conceived. Serum B concentrations were generally higher (P < 0.05) in animals that conceived especially on day 21 when B concentrations were higher (P < 0.05) than at estrus. Serum P concentrations were high (> 3.5 mmol L -1 ), but highest in animals that conceived especially on day 21. It is concluded that P and B may be dietary factors limiting first service conception in beef cows fed conserved forage. Nous avons entrepris une étude pour examiner les concentrations de minéraux dans le sérum à l'oestrus et à la conception en première insémination (CPI) chez des bovins à viande nourris de fourrages conservés. L'étude portait sur des génisses nullipares d'un an ainsi que sur des génisses primipares de deux ans et sur des vaches multipares, les deux dernières catégories étant encore allaitantes. Des prélèvements sanguins étaient effectués à la première insémination, soit dans les 12 heures d'état d'acceptation du chevauchement et 21 heures après. Le sérum était analysé par spectrophotométrie ICAP sur ses teneurs en Ca, P, Mg, K, S, Na, Fe, Cu, Mn, Zn et B. Les génisses réparties en 4 groupes recevaient en plus de foin à volonté (1,71 % K, 0,20 %, P; 8 % PB et 41 % ADF) un complément de grain à raison de 3,0 ou 2,5 kg par jour chacune selon qu'elles étaient nullipares ou primipares. Les vaches adultes nourries individuellemen...

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“…Estrogens do increase ceruloplasmin levels in females, but in copper deficiency the incorporation of copper into ceruloplasmin is inhibited, and possibly the levels of estrogen in intact prepubertal females are too low to stimulate ceruloplasmin activity 45,89. Increases in the serum copper and ceruloplasmin levels of female rats and other animals with estrogen treatment are clear, and depend upon the duration of hormonal treatment56, 60,83,92,117,182,183,274,290 The increases occurred at the expense of hepatic copper and were not due to increased intestinal absorption, so prolonged estrogen treatment leads to an alteration in the distribution of copper. Copper is also known to affect the level of norepinephrine and dopamine in brain by synthesis and/or release of neurotransmitters 212.…”

Section: Copper Deficiency In Female Reproduction; Pregnancy and Infamentioning

confidence: 99%

Zinc, copper and selenium in reproduction

1994

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Of the nine biological trace elements, zinc, copper and selenium are important in reproduction in males and females. Zinc content is high in the adult testis, and the prostate has a higher concentration of zinc than any other organ of the body. Zinc deficiency first impairs angiotensin converting enzyme (ACE) activity, and this in turn leads to depletion of testosterone and inhibition of spermatogenesis. Defects in spermatozoa are frequently observed in the zinc-deficient rat. Zinc is thought to help to extend the functional life span of the ejaculated spermatozoa. Zinc deficiency in the female can lead to such problems as impaired synthesis/secretion of (FSH) and (LH), abnormal ovarian development, disruption of the estrous cycle, frequent abortion, a prolonged gestation period, teratogenicity, stillbirths, difficulty in parturition, pre-eclampsia, toxemia and low birth weights of infants. The level of testosterone in the male has been suggested to play a role in the severity of copper deficiency. Copper-deficient female rats are protected against mortality due to copper deficiency, and the protection has been suggested to be provided by estrogens, since estrogens alter the subcellular distribution of copper in the liver and increase plasma copper levels by inducing ceruloplasmin synthesis. The selenium content of male gonads increases during pubertal maturation. Selenium is localized in the mitochondrial capsule protein (MCP) of the midpiece. Maximal incorporation in MCP occurs at steps 7 and 12 of spermatogenesis and uptake decreases by step 15. Selenium deficiency in females results in infertility, abortions and retention of the placenta. The newborns from a selenium-deficient mother suffer from muscular weakness, but the concentration of selenium during pregnancy does not have any effect on the weight of the baby or length of pregnancy. The selenium requirements of a pregnant and lactating mother are increased as a result of selenium transport to the fetus via the placenta and to the infant via breast milk.

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Mechanism for hormone-induced alterations in serum ceruloplasmin

Cited by 61 publications

References 0 publications

Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice

Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice

Serum mineral concentrations in relation to estrus and conception in beef heifers and cows fed conserved forage

Zinc, copper and selenium in reproduction

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