Mechanism for action of electromagnetic fields on cells

Panagopoulos, Dimitris J.; Karabarbounis, A.; Margaritis, Lukas H.

doi:10.1016/s0006-291x(02)02393-8

Cited by 258 publications

(213 citation statements)

References 52 publications

(65 reference statements)

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“…The effect depends not only on ultrasound exposure, but also on the inherent characteristics of the species' blood. The mechanism of the biological activity of physical agents is caused by the external field forced vibrations of ions near the surface of the CPM, fluctuations in the channels, and the ability of accelerated ions to penetrate the membrane pores and specialized ion channels due to the active transport systems [13]. It was shown that the modulated UHF, EMR or US effect at some frequencies can cause a change in enzymatic activity towards both activation and inhibition [14,15].…”

Section: Discussionmentioning

confidence: 99%

Studies of Frequency–Dependent Changes under Modulated Ultrasound Exposure on Cells in Suspension

Oleshkevich¹

2015

Int J Biomed

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Characteristics of the modulated ultrasound effect (range of modulation frequencies 10Hz-1000Hz intensity 0.2 W/cm 2 ) on white blood cells (WBCs) from different animals were studied. The quantitative ratio of WBCs was the most strongly altered by ultrasonic modulation frequency 1000 Hz. This frequency led to degenerative changes of cells. The presence of non-typeable or destroyed cells in smears was indicated. The results obtained demonstrated the possibility of directed impact on different WBC forms.

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Section: Discussionmentioning

confidence: 99%

Studies of Frequency–Dependent Changes under Modulated Ultrasound Exposure on Cells in Suspension

Oleshkevich¹

2015

Int J Biomed

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“…It was shown that coherent vibration of electric charge was able to affect electro sensitive channels on the membrane which could lead to the disruption of cell′s electrochemical balance and function. The proposed model theoretically proved that pulsed EM fi elds could be twice as effective biologically as the continuous ones (32). Furthermore there have been a number of papers connecting exposure of RF/MW radiation with excessive formation of free radicals (67)(68)(69)(70)(71)(72)(73)(74).…”

Section: Biological Mechanisms Of Rf/mw Actionmentioning

confidence: 95%

“…The process is even more expressed when radicals are attached to cellular structures such as cell membrane (31). A biophysical model for the effect of oscillating electric fi elds on cells has been given by Panagopoulos et al in 2002. This model is based on forced-vibration of free ions on the surface of a plasma membrane caused by an external oscillating fi eld.…”

Section: Biological Mechanisms Of Rf/mw Actionmentioning

confidence: 99%

Biological indicators in response to radiofrequency/microwave exposure

Marjanović

Pavičić

Trošić

2012

Archives of Industrial Hygiene and Toxicology

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Over the years, due to rapid technological progress, radiation from man-made sources exceeded that of natural origin. There is a general concern regarding a growing number of appliances that use radiofrequency/ microwave (RF/MW) radiation with particular emphasis on mobile communication systems. Since nonthermal biological effects and mechanisms of RF/MW radiation are still uncertain, laboratory studies on animal models, tissues, cells, and cell free system are of extraordinary importance in bioelectromagnetic research. We believe that such investigations play a supporting role in public risk assessment. Cellular systems with the potential for a clear response to RF/MW exposures should be used in those studies. It is known that organism is a complex electrochemical system where processes of oxidation and reduction regularly occur. One of the plausible mechanisms is connected with generation of reactive oxygen species (ROS). Depending on concentration, ROS can have both benefi cial and deleterious effects. Positive effects are connected with cell signalling, defence against infectious agents, and proliferative cell ability. On the other hand, excessive production, which overloads antioxidant defence mechanism, leads to cellular damage with serious potential for disease development. ROS concentration increase within the cell caused by RF/MW radiation seems to be a biologically relevant hypothesis to give clear insight into the RF/MW action at non-thermal level of radiation. In order to better understand the exact mechanism of action and its consequences, further research is needed in the fi eld. We would like to present current knowledge on possible biological mechanisms of RF/MW actions.

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“…EM radiation has been shown to cause changes in living tissues such as altering the permeability of the blood-brain barrier, encephalogram and blood pressure, mostly through 'nonthermal' pathways [16]. Lower frequency EM fields appear to be more bioactive than higher frequency fields of the same rest characteristics [17]. Extremely low frequency (ELF) EM fields, of the order of several V/m, as occurring with both GSM (Groupe Spécial Mobile) and DCS (digital cellular system) transmissions, are able to disrupt cell function by irregular gating of electro sensitive ion channels on the plasma membranes of cells [18].…”

Section: Journal Of Clinical and Analytical Medicinementioning

confidence: 99%