Mechanism behind Augmentation in Baroreflex Sensitivity after Acute Exercise in Spontaneously Hypertensive Rats

Minami, Naoyoshi; Mori, Nobuyoshi; Nagasaka, Makoto; Itoh, Osamu; Kurosawa, Hájíme; Kanazawa, Masayuki; Kaku, K.; Lee, Eigyoku; Kohzuki, Masahiro

doi:10.1291/hypres.29.117

Cited by 14 publications

(12 citation statements)

References 40 publications

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“…From the results of the present study, it is not clear why BRS was decreased following sprint interval exercise. In rats, the baroreflex response to exercise is likely associated with changes in sympathetic activity because BRS was unaltered following changes in blood flow alone (Minami et al, 2006). However, the participants in the present investigation experienced changes in BRS that were maintained longer than changes in sympathetic activity as indicated by HRV.…”

Section: Discussionmentioning

confidence: 99%

Autonomic recovery following sprint interval exercise

Stuckey¹,

Tordi²,

Mourot³

et al. 2011

Scandinavian Med Sci Sports

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The autonomic nervous activity was assessed following supramaximal exercise through heart rate (HR) and blood pressure (BP) variability (HRV and BPV) and baroreflex sensitivity (BRS). The beat-to-beat HR and BP were recorded during the supine and standing states before (PRE) and at 60 (R60) and 120 min (R120) following single (one Wingate, 1W) and multiple sprint intervals (four Wingates interspersed with 4 min of light cycling, 4W). The supine low frequency (LF) component was increased (P<0.001) and the high frequency (HF) was reduced (P<0.01) at R60 (LF, 178.1 ± 11.0; HF, 74.8 ± 10.5) compared with PRE (LF, 140.2 ± 7.4; HF, 110.4 ± 7.2) after both exercises. Supine systolic BPV LF:HF was higher at R60 (4.6 ± 1.4) compared with PRE (6.8 ± 2.4) only after 4W (P=0.035). Supine BRS was lower (P<0.001) at R60 (6.8 ± 1.1) than at PRE (15.3 ± 1.8) and R120 (11.3 ± 1.3). BRS at R120 remained lower after 4W (P=0.02). Standing BRS was less (P<0.001) at R60 (2.3 ± 0.5) than at PRE (5.6 ± 0.8) or R120 (3.7 ± 0.6) and returned to PRE values only after 1W. We concluded that (a) autonomic balance is shifted to a greater sympathetic and less parasympathetic activation following both types of exercise, (b) it takes longer than 1 h to recover following supramaximal exercise and (c) the recovery is longer after 4W than 1W.

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Section: Discussionmentioning

confidence: 99%

Autonomic recovery following sprint interval exercise

Stuckey¹,

Tordi²,

Mourot³

et al. 2011

Scandinavian Med Sci Sports

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“…The method used to estimate sympathetic activity by power spectral analysis of SBP has been described elsewhere (16).…”

Section: Evaluation Of Sympathetic Activitymentioning

confidence: 99%

Effects of Antihypertensive Drugs and Exercise Training on Insulin Sensitivity in Spontaneously Hypertensive Rats

et al. 2008

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We examined the effects of antihypertensive drugs, exercise training, and combinations thereof on insulin sensitivity (IS), and the association between this relation and sympathetic activity, muscle fiber composition, and capillary density in spontaneously hypertensive rats (SHR). Six-week-old male SHR were allocated to 7 groups: a control group (C), and groups treated with azelnidipine (Aze) (a calcium channel blocker),

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“…Although attenuation of baroreceptor reflex sensitivity was observed during dynamic exercise (increased pressure variability with decreased reflex gain [29]), baroreflex sensitivity was augmented after one bout of exercise [18,30] or following exercise training [31]. Improvement of baroreflex gain was shown to be independent of exercise-induced hemodynamic response, but conditioned by the stimuli conveyed by peripheral afferents to the NTS during exercise [30]. Indeed, aortic nerve activity/systolic pressure relationship was shown to be steeper in both SHR and normotensive controls after exercise training [19].…”

Section: Introductionmentioning

confidence: 99%

The NTS and integration of cardiovascular control during exercise in normotensive and hypertensive individuals

Michelini

2007

Current Science Inc

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Due to upward resetting of baroreceptors, tachycardia coexists with increased pressure during dynamic exercise. This review critically evaluates current knowledge of proposed mechanisms to explain the continuous resetting of baroreflex control of heart rate and sympathetic nerve activity during and after exercise and exercise training. Of interest is the exercise-induced upward resetting that occurs in hypertensive and normotensive individuals. Accumulated evidence indicates that not only somatosensory afferents, but also inputs from central command projecting to the nucleus tractus solitarius (NTS) in the dorsal brainstem may mediate inhibition of excitatory neurotransmission on barosensitive neurons. Specific coordinated activation of vasopressinergic and oxytocinergic projections to the NTS is essential to tonically maintain baroreflex sensitivity and to adjust heart rate and cardiac output to circulatory demand at rest and during exercise in both sedentary and trained individuals. These findings reinforce the paramount importance of the NTS in integration of cardiovascular control during exercise.

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Mechanism behind Augmentation in Baroreflex Sensitivity after Acute Exercise in Spontaneously Hypertensive Rats

Abstract: A single bout of dynamic exercise increases baroreflex sensitivity (BRS) in spontaneously hypertensive rats (SHR). We examined whether change in hemodynamics (increases in blood pressure and heart rate) asso-

Cited by 14 publications

References 40 publications

Autonomic recovery following sprint interval exercise

Autonomic recovery following sprint interval exercise

Effects of Antihypertensive Drugs and Exercise Training on Insulin Sensitivity in Spontaneously Hypertensive Rats

The NTS and integration of cardiovascular control during exercise in normotensive and hypertensive individuals

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