“…The 1,3,4‐thiadiazoles are known to exhibit a wide range of biological actions such as antifungal, anticancer, antibacterial, anti‐leishmanial, antitubercular, antioxidative, and antidiabetic agents. [ 43–48 ] Additionally, they serve as the initial building blocks for the production of many different kinds of chemical compounds, including sulfa medicines, fungicides, dyes, and catalysts for chemical reactions. Megazol (antiparasitic), acetazolamide (carbonic anhydrase inhibitor), methazolamide (diuretic), sulfamethizole (antibacterial sulfonamide), and Cefazolin (first‐generation cephalosporin) are some of the most well‐known thiadiazole‐containing medications in the market (Figure 2).…”